PL415936A1 - Bone scaffold based on -1,3-glucan (curdlan) and bioceramics and method for producing it - Google Patents
Bone scaffold based on -1,3-glucan (curdlan) and bioceramics and method for producing itInfo
- Publication number
- PL415936A1 PL415936A1 PL415936A PL41593616A PL415936A1 PL 415936 A1 PL415936 A1 PL 415936A1 PL 415936 A PL415936 A PL 415936A PL 41593616 A PL41593616 A PL 41593616A PL 415936 A1 PL415936 A1 PL 415936A1
- Authority
- PL
- Poland
- Prior art keywords
- kurdlan
- bioceramics
- prepared
- solution
- naoh
- Prior art date
Links
- 239000003462 bioceramic Substances 0.000 title abstract 5
- 210000000988 bone and bone Anatomy 0.000 title abstract 5
- 229920002558 Curdlan Polymers 0.000 title abstract 2
- 239000001879 Curdlan Substances 0.000 title abstract 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 title abstract 2
- 229940078035 curdlan Drugs 0.000 title abstract 2
- 235000019316 curdlan Nutrition 0.000 title abstract 2
- 229920001503 Glucan Polymers 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 9
- 239000001506 calcium phosphate Substances 0.000 abstract 3
- 229910000389 calcium phosphate Inorganic materials 0.000 abstract 3
- 235000011010 calcium phosphates Nutrition 0.000 abstract 3
- 239000000463 material Substances 0.000 abstract 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract 3
- 230000004071 biological effect Effects 0.000 abstract 2
- 238000000338 in vitro Methods 0.000 abstract 2
- 229920002498 Beta-glucan Polymers 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 206010067268 Post procedural infection Diseases 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 239000007943 implant Substances 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011858 nanopowder Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000001172 regenerating effect Effects 0.000 abstract 1
- 230000008439 repair process Effects 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Rusztowanie kostne na bazie bioceramiki fosforanowo - wapniowej i kurdlanu, charakteryzuje się tym, że zawiera 6 - 20% (w/v) roztwór ß-1,3-glukanu zwany dalej kurdlanem, przygotowany w 0,1 - 0,5 M roztworze zasady sodowej (NaOH), korzystnie 0,3 M (komponent x) oraz 2 - 90% (w/v) bioceramiki fosforanowo - wapniowej rozprowadzonej w przygotowanym roztworze kurdlanu, w postaci nanoproszku, proszku lub granul, o rozmiarze 0,1 - 1,0 mm wypalanych w temperaturach 500°C - 1300°C, korzystnie 1100 - 1200°C (komponent y), przy czym najkorzystniej gdy proporcje wagowe stałych składników wynoszą odpowiednio 7 - 10% kurdlanu i 60 - 80% bioceramiki, a maksymalna ilość komponentu y (w gramach na 100 ml roztworu kurdlanu w NaOH) w zależności od komponentu x (w gramach na 100 ml NaOH), wynika ze wzoru: ymax(x)=0,079x2-6,1557x+123,57. Przedmiotem zgłoszenia jest także sposób wytwarzania rusztowania kostnego na bazie bioceramiki fosforanowo - wapniowej i kurdlanu. Materiał przygotowany ze względu na swoje właściwości biologiczne nadaje się do stosowania zarówno in vitro w inżynierii tkankowej jako rusztowanie kostne, wstępnie zasiedlane komórkami osteoprogeniterowymi, wyprowadzonymi z organizmu pacjenta w celu wygenerowania tzw. żywego wszczepu, jak i in vitro w medycynie regeneracyjnej, jako materiał przyspieszający procesy regeneracyjne w miejscu implantacji. Ponadto, przygotowany materiał nadaje się do stosowania jako baza do immobilizacji substancji bioaktywnych, również termowrażliwych (np. białek adhezyjnych, czynników wzrostu, antybiotyków peptydowych), metodą pułapkowania wewnątrz struktury polimerowej żelu kurdlanowego (na etapie wytwarzania rusztowania kostnego), co wpłynie na poprawę jego właściwości biologicznych oraz będzie chronić przed post - operacyjnymi infekcjami.Bone scaffolding based on calcium phosphate bioceramics and kurdlan, characterized by the fact that it contains 6 - 20% (w / v) solution of ß-1,3-glucan, hereinafter referred to as curdlan, prepared in 0.1 - 0.5 M base solution Sodium (NaOH), preferably 0.3 M (component x) and 2 - 90% (w / v) calcium phosphate bioceramics distributed in the prepared solution of kurdlan, in the form of nanopowder, powder or granules, size 0.1 - 1, 0 mm fired at temperatures of 500 ° C - 1300 ° C, preferably 1100 - 1200 ° C (components y), most preferably when the weight proportions of solid components are 7 - 10% kurdlan and 60 - 80% bioceramics, respectively, and the maximum amount of component y (in grams per 100 ml of kurdlan solution in NaOH) depending on the component x (in grams per 100 ml of NaOH), results from the formula: ymax (x) = 0.079x2-6.1557x + 123.57. The subject of the application is also a method of producing bone scaffolding based on calcium phosphate bioceramics and kurdlan. The material prepared due to its biological properties is suitable for use in vitro in tissue engineering as a bone scaffold, pre-populated with osteoprogeniter cells, derived from the patient's body to generate the so-called live implant, as well as in vitro in regenerative medicine, as a material accelerating regenerative processes at the implantation site. In addition, the prepared material is suitable for use as a base for the immobilization of bioactive substances, also thermosensitive (e.g. adhesive proteins, growth factors, peptide antibiotics), by trapping inside the polymer structure of the kurdlan gel (at the stage of producing bone scaffolding), which will improve its biological properties and will protect against post-operative infections.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL415936A PL229329B1 (en) | 2016-01-27 | 2016-01-27 | Bone scaffold based on -1,3-glucan (curdlan) and bioceramics and method for producing it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL415936A PL229329B1 (en) | 2016-01-27 | 2016-01-27 | Bone scaffold based on -1,3-glucan (curdlan) and bioceramics and method for producing it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL415936A1 true PL415936A1 (en) | 2017-02-27 |
| PL229329B1 PL229329B1 (en) | 2018-07-31 |
Family
ID=58092075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL415936A PL229329B1 (en) | 2016-01-27 | 2016-01-27 | Bone scaffold based on -1,3-glucan (curdlan) and bioceramics and method for producing it |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL229329B1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL247449B1 (en) * | 2022-10-05 | 2025-07-07 | Univ Medyczny W Lublinie | Nanocomposite hydroxyapatite-polymer granulate based on a curdlan-chitosan matrix and a method for its production |
-
2016
- 2016-01-27 PL PL415936A patent/PL229329B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL229329B1 (en) | 2018-07-31 |
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