PL437235A1 - Biomaterial based on natural polysaccharide - β-1,3-glucan (curdlan) and ceramics for applications in bone tissue engineering and method of its preparation - Google Patents
Biomaterial based on natural polysaccharide - β-1,3-glucan (curdlan) and ceramics for applications in bone tissue engineering and method of its preparationInfo
- Publication number
- PL437235A1 PL437235A1 PL437235A PL43723521A PL437235A1 PL 437235 A1 PL437235 A1 PL 437235A1 PL 437235 A PL437235 A PL 437235A PL 43723521 A PL43723521 A PL 43723521A PL 437235 A1 PL437235 A1 PL 437235A1
- Authority
- PL
- Poland
- Prior art keywords
- curdlan
- glucan
- hap
- natural polysaccharide
- ceramics
- Prior art date
Links
- 229920002558 Curdlan Polymers 0.000 title abstract 7
- 239000001879 Curdlan Substances 0.000 title abstract 7
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 title abstract 7
- 229940078035 curdlan Drugs 0.000 title abstract 7
- 235000019316 curdlan Nutrition 0.000 title abstract 7
- 229920002498 Beta-glucan Polymers 0.000 title abstract 6
- 239000000919 ceramic Substances 0.000 title abstract 6
- 239000012620 biological material Substances 0.000 title abstract 4
- 150000004676 glycans Chemical class 0.000 title abstract 4
- 229920001282 polysaccharide Polymers 0.000 title abstract 4
- 239000005017 polysaccharide Substances 0.000 title abstract 4
- 210000000988 bone and bone Anatomy 0.000 title 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 5
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 5
- 108010046377 Whey Proteins Proteins 0.000 abstract 2
- 102000007544 Whey Proteins Human genes 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 235000021119 whey protein Nutrition 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000011858 nanopowder Substances 0.000 abstract 1
- 235000004252 protein component Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
Przedmiotem zgłoszenia jest biomateriał na bazie naturalnego polisacharydu —β-1,3-glukanu (kurdlanu) oraz ceramiki hydroksyapatytowej (HAp), który charakteryzuje się tym, że zawiera komponent białkowy - izolat białka serwatkowego (WPI) w ilości 20 - 50% (w/v), korzystnie 35% (w/v), zaś pozostałe składniki jak β-1,3-glukan (kurdlan) oraz ceramika hydroksyapatytowa (HAp) występują w ilościach: naturalny polisacharyd —β-1,3-glukan (kurdlan) w ilości 6 - 20% (w/v), korzystnie 8% (w/v), a ceramika hydroksyapatytowa (HAp) w ilości od 10 g do 180 g w odniesieniu do 100 ml wodnego roztworu. Zgłoszenie obejmuje także sposób wytwarzania biomateriału na bazie naturalnego polisacharydu —β-1,3-glukanu (kurdlanu) oraz ceramiki hydroksyapatytowej (HAp) charakteryzujący się tym że 20 - 50% (w/v) roztwór izolatu białka serwatkowego (WPI), korzystnie 35% (w/v), przygotowuje się w wodzie destylowanej i dodaje się do proszku β-1,3-glukanu (kurdlanu), tak aby stężenie kurdlanu względem 100 ml roztworu WPI wynosiło 6 - 20% (w/v), korzystnie 8% (w/v), następnie do takiej mieszaniny dodaje się ceramikę hydroksyapatytową (HAp) w postaci nanoproszku, proszku lub granul o rozmiarze 0,1 – 1,0 mm, wypalanych w temperaturze 500 - 1300°C, w ilości 10 - 180 g, tak otrzymany biomateriał inkubuje od 1 do 60 minut, korzystnie 15 minut w temperaturze 90 - 120°C, korzystnie 90°C, a następnie sterylizuje.The subject of the application is a biomaterial based on the natural polysaccharide -β-1,3-glucan (curdlan) and hydroxyapatite ceramics (HAp), which is characterized by the fact that it contains a protein component - whey protein isolate (WPI) in the amount of 20 - 50% (in / v), preferably 35% (w / v), and the remaining ingredients such as β-1,3-glucan (curdlan) and hydroxyapatite ceramics (HAp) are present in the following amounts: natural polysaccharide -β-1,3-glucan (curdlan) in an amount of 6-20% (w / v), preferably 8% (w / v), and a hydroxyapatite ceramic (HAp) in an amount of 10 to 180 g based on 100 ml of aqueous solution. The application also covers a method for the production of a biomaterial based on natural polysaccharide -β-1,3-glucan (curdlan) and hydroxyapatite ceramics (HAp), characterized in that a 20 - 50% (w / v) solution of whey protein isolate (WPI), preferably 35 % (w / v), is prepared in distilled water and added to the β-1,3-glucan (curdlan) powder so that the concentration of curdlan relative to 100 ml of WPI solution is 6 - 20% (w / v), preferably 8 % (w / v), then hydroxyapatite ceramics (HAp) in the form of nanopowder, powder or granules with a size of 0.1 - 1.0 mm, fired at a temperature of 500 - 1300 ° C, in the amount of 10 - 180 are added to this mixture. g, the biomaterial thus obtained is incubated for 1 to 60 minutes, preferably 15 minutes at a temperature of 90-120 ° C, preferably 90 ° C, and then sterilized.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL437235A PL240725B1 (en) | 2021-03-08 | 2021-03-08 | Biomaterial based on natural polysaccharide - β-1,3-glucan (curdlan) and ceramics for applications in bone tissue engineering and method of its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL437235A PL240725B1 (en) | 2021-03-08 | 2021-03-08 | Biomaterial based on natural polysaccharide - β-1,3-glucan (curdlan) and ceramics for applications in bone tissue engineering and method of its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL437235A1 true PL437235A1 (en) | 2021-12-13 |
| PL240725B1 PL240725B1 (en) | 2022-05-23 |
Family
ID=80053438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL437235A PL240725B1 (en) | 2021-03-08 | 2021-03-08 | Biomaterial based on natural polysaccharide - β-1,3-glucan (curdlan) and ceramics for applications in bone tissue engineering and method of its preparation |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL240725B1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL247449B1 (en) * | 2022-10-05 | 2025-07-07 | Univ Medyczny W Lublinie | Nanocomposite hydroxyapatite-polymer granulate based on a curdlan-chitosan matrix and a method for its production |
| PL245926B1 (en) * | 2022-10-05 | 2024-11-04 | Univ Medyczny W Lublinie | Nanocomposite bone scaffold based on curdlan-chitosan matrix and hydroxyapatite and method of its production |
-
2021
- 2021-03-08 PL PL437235A patent/PL240725B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL240725B1 (en) | 2022-05-23 |
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