PL417574A1 - Crystalline form of the complex of nitrate(V) aqua((2S)-2-amino-3-(4-hydroxy-3,5-diiodo phenyl)-propane)(1,10-phenanthroline) copper(II) and method for producing it - Google Patents
Crystalline form of the complex of nitrate(V) aqua((2S)-2-amino-3-(4-hydroxy-3,5-diiodo phenyl)-propane)(1,10-phenanthroline) copper(II) and method for producing itInfo
- Publication number
- PL417574A1 PL417574A1 PL417574A PL41757416A PL417574A1 PL 417574 A1 PL417574 A1 PL 417574A1 PL 417574 A PL417574 A PL 417574A PL 41757416 A PL41757416 A PL 41757416A PL 417574 A1 PL417574 A1 PL 417574A1
- Authority
- PL
- Poland
- Prior art keywords
- amino
- phenanthroline
- hydroxy
- copper
- nitrate
- Prior art date
Links
- AGGOVIULSJAVMD-YFKPBYRVSA-N 4-[(2S)-2-aminopropyl]-2,6-diiodophenol Chemical compound N[C@@H](C)CC1=CC(=C(C(=C1)I)O)I AGGOVIULSJAVMD-YFKPBYRVSA-N 0.000 title abstract 3
- 229910002651 NO3 Inorganic materials 0.000 title abstract 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 title 1
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 title 1
- XOCNEEJNJTZFKE-UHFFFAOYSA-N copper;1,10-phenanthroline;dinitrate Chemical compound [Cu+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O.C1=CN=C2C3=NC=CC=C3C=CC2=C1 XOCNEEJNJTZFKE-UHFFFAOYSA-N 0.000 abstract 2
- PPQJCISYYXZCAE-UHFFFAOYSA-N 1,10-phenanthroline;hydrate Chemical compound O.C1=CN=C2C3=NC=CC=C3C=CC2=C1 PPQJCISYYXZCAE-UHFFFAOYSA-N 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical compound CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 1
- 238000001042 affinity chromatography Methods 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- XTVVROIMIGLXTD-UHFFFAOYSA-N copper(II) nitrate Chemical compound [Cu+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O XTVVROIMIGLXTD-UHFFFAOYSA-N 0.000 abstract 1
- CLOGWEPTDWTHCS-UHFFFAOYSA-N copper;1,10-phenanthroline Chemical compound [Cu+2].C1=CN=C2C3=NC=CC=C3C=CC2=C1 CLOGWEPTDWTHCS-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000002594 sorbent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Zgłoszenie dotyczy krystalicznej formy kompleksu azotan(V) aqua((2S)-2-amino-3-(4-hydroksy-3,5-dijodofenylo)-propano)(1,10-fenantrolina)miedzi(II) o wzorze 1, znajdującej zastosowanie jako składnik sorbentów w chromatografii powinowactwa oraz polimerów wykorzystywanych w medycynie. Ujawniono również sposób wytwarzania krystalicznej formy kompleksu azotan(V) aqua((2S)-2-amino-3-(4-hydroksy-3,5-dijodofenylo)-propano)(1,10-fenantrolina)miedzi(II) o wzorze 1, który charakteryzuje się tym, że jedną część molową uwodnionej soli azotanu (V) miedzi (II), rozpuszcza się w wodzie i poddaje reakcji z dwiema częściami molowymi wodnego roztworu dihydratu kwasu (2S)-2-amino-3-(4-hydroksy-3,5-dijodofenylo)-propanowego z dodatkiem kilku kropel stężonego kwasu azotowego (V) i z jedną częścią molową metanolowego roztworu hydratu 1,10-fenantroliny, a po minimum jednym tygodniu otrzymuje się krystaliczną formę kompleksu azotan(V)aqua((2S)-2-amino-3-(4-hydroksy-3,5-dijodofenylo)-propano)(1,10-fenantrolina)miedzi(II) o wzorze 1.The application relates to the crystalline form of the (V) aqua ((2S) -2-amino-3- (4-hydroxy-3,5-diiodophenyl) propane) (1,10-phenanthroline) copper (II) nitrate complex of formula 1, which is used as a component of sorbents in affinity chromatography and polymers used in medicine. Also disclosed is a method for producing the crystalline form of the (V) aqua ((2S) -2-amino-3- (4-hydroxy-3,5-diiodophenyl) propane) (1,10-phenanthroline) copper (II) nitrate complex 1, which is characterized in that one molar part of the hydrated copper (II) nitrate salt dissolves in water and reacts with two molar parts of the aqueous solution of (2S) -2-amino-3- (4- dihydrate hydroxy-3,5-diiodophenyl) propanoate with the addition of a few drops of concentrated nitric acid (V) and with one molar part of the methanolic solution of 1,10-phenanthroline hydrate, and after a minimum of one week the crystalline form of the nitrate (V) aqua complex is obtained (( 2S) -2-amino-3- (4-hydroxy-3,5-diiodophenyl) propane) (1,10-phenanthroline) copper (II) of formula 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL417574A PL229342B1 (en) | 2016-06-14 | 2016-06-14 | Crystalline form of the complex of nitrate(V) aqua((2S)-2-amino-3-(4-hydroxy-3,5-diiodo phenyl)-propane)(1,10-phenanthroline) copper(II) and method for producing it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL417574A PL229342B1 (en) | 2016-06-14 | 2016-06-14 | Crystalline form of the complex of nitrate(V) aqua((2S)-2-amino-3-(4-hydroxy-3,5-diiodo phenyl)-propane)(1,10-phenanthroline) copper(II) and method for producing it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL417574A1 true PL417574A1 (en) | 2017-02-27 |
| PL229342B1 PL229342B1 (en) | 2018-07-31 |
Family
ID=58092041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL417574A PL229342B1 (en) | 2016-06-14 | 2016-06-14 | Crystalline form of the complex of nitrate(V) aqua((2S)-2-amino-3-(4-hydroxy-3,5-diiodo phenyl)-propane)(1,10-phenanthroline) copper(II) and method for producing it |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL229342B1 (en) |
-
2016
- 2016-06-14 PL PL417574A patent/PL229342B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL229342B1 (en) | 2018-07-31 |
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