PL4182308T3 - Pochodne pirydazynyloaminowe jako inhibitory ALK5 - Google Patents
Pochodne pirydazynyloaminowe jako inhibitory ALK5Info
- Publication number
- PL4182308T3 PL4182308T3 PL21743186.5T PL21743186T PL4182308T3 PL 4182308 T3 PL4182308 T3 PL 4182308T3 PL 21743186 T PL21743186 T PL 21743186T PL 4182308 T3 PL4182308 T3 PL 4182308T3
- Authority
- PL
- Poland
- Prior art keywords
- pyridazinylamine
- derivatives
- alk5 inhibitors
- alk5
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- LETVJWLLIMJADE-UHFFFAOYSA-N pyridazin-3-amine Chemical class NC1=CC=CN=N1 LETVJWLLIMJADE-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20185890 | 2020-07-15 | ||
| PCT/EP2021/069649 WO2022013307A1 (en) | 2020-07-15 | 2021-07-14 | Pyridazinyl amino derivatives as alk5 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL4182308T3 true PL4182308T3 (pl) | 2025-01-07 |
Family
ID=71620257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL21743186.5T PL4182308T3 (pl) | 2020-07-15 | 2021-07-14 | Pochodne pirydazynyloaminowe jako inhibitory ALK5 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US12479826B2 (pl) |
| EP (1) | EP4182308B1 (pl) |
| JP (1) | JP7686741B2 (pl) |
| KR (1) | KR20230051500A (pl) |
| CN (1) | CN116096719B (pl) |
| AR (1) | AR122986A1 (pl) |
| AU (1) | AU2021307559A1 (pl) |
| BR (1) | BR112023000588A8 (pl) |
| CA (1) | CA3184990A1 (pl) |
| DK (1) | DK4182308T3 (pl) |
| ES (1) | ES2997111T3 (pl) |
| FI (1) | FI4182308T3 (pl) |
| HR (1) | HRP20241617T1 (pl) |
| HU (1) | HUE069150T2 (pl) |
| MX (1) | MX2023000521A (pl) |
| PL (1) | PL4182308T3 (pl) |
| PT (1) | PT4182308T (pl) |
| SI (1) | SI4182308T1 (pl) |
| TW (1) | TWI914378B (pl) |
| WO (1) | WO2022013307A1 (pl) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7702205B2 (ja) * | 2021-09-15 | 2025-07-03 | 株式会社東芝 | 新規アミン化合物、酸性ガス吸収剤、酸性ガスの除去方法及び酸性ガス除去 |
| CN114957331A (zh) * | 2022-04-22 | 2022-08-30 | 北京康辰药业股份有限公司 | 磷酸酯取代的环丙酰胺衍生喹唑啉类化合物的制备方法 |
| WO2024180206A1 (en) | 2023-03-02 | 2024-09-06 | Chiesi Farmaceutici S.P.A. | Pyridazinyl amino derivatives as alk5 inhibitors |
| WO2024180207A1 (en) | 2023-03-02 | 2024-09-06 | Chiesi Farmaceutici S.P.A. | Pyridazinyl amino derivatives as alk5 inhibitors |
| KR20240159754A (ko) * | 2023-04-28 | 2024-11-06 | 한국원자력의학원 | N-메틸피페라진 에탄올 카바메이트(N-methylpiperazine ethanol carbamate) 구조를 포함하는 신규 화합물 및 이의 용도 |
| WO2025132458A1 (en) | 2023-12-18 | 2025-06-26 | Chiesi Farmaceutici S.P.A. | Pyridazinyl amino derivatives as alk5 inhibitors |
| WO2025132460A1 (en) | 2023-12-18 | 2025-06-26 | Chiesi Farmaceutici S.P.A. | Pyridazinyl amino derivatives as alk5 inhibitors |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4798000A (en) | 1999-04-09 | 2000-11-14 | Smithkline Beecham Corporation | Triarylimidazoles |
| AR029803A1 (es) | 2000-02-21 | 2003-07-16 | Smithkline Beecham Plc | Imidazoles sustituidos con piridilo y composiciones farmaceuticas que las comprenden |
| GB0007405D0 (en) | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
| AU2001290912A1 (en) | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| DK1330452T3 (da) | 2000-09-20 | 2009-03-16 | Ortho Mcneil Janssen Pharm | Pyrazinderivater som modulatorer af tyrosinkinaser |
| AR039241A1 (es) | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
| WO2004024159A1 (en) | 2002-09-10 | 2004-03-25 | Scios Inc. | INHIBITORS OF TFGβ |
| US7390907B2 (en) | 2003-09-30 | 2008-06-24 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| CA2657227A1 (en) | 2006-07-14 | 2008-01-17 | Novartis Ag | Pyrimidine derivatives as alk-5 inhibitors |
| KR101150581B1 (ko) | 2007-07-26 | 2012-06-11 | 노파르티스 아게 | 유기 화합물 |
| EA201000615A1 (ru) | 2007-10-17 | 2010-12-30 | Новартис Аг | Производные имидазо[1,2-а]пиридина, применимые в качестве ингибиторов апк (активиноподобной киназы) |
| AR070127A1 (es) | 2008-01-11 | 2010-03-17 | Novartis Ag | Pirrolo - pirimidinas y pirrolo -piridinas |
| JP5584138B2 (ja) | 2008-01-11 | 2014-09-03 | ノバルティス アーゲー | キナーゼ阻害剤としてのピリミジン類 |
| US8343966B2 (en) * | 2008-01-11 | 2013-01-01 | Novartis Ag | Organic compounds |
| EP2307402B1 (en) | 2008-04-29 | 2012-11-07 | Novartis AG | Imidazo-pyridine derivatives as activin-like receptor kinase (alk4 or alk5) inhibitors |
| WO2011054433A1 (en) | 2009-11-07 | 2011-05-12 | Merck Patent Gmbh | Heteroarylaminoquinolines as tgf-beta receptor kinase inhibitors |
| RU2612958C2 (ru) | 2011-07-13 | 2017-03-14 | Ск Кемикалз Ко., Лтд. | 2-пиридилзамещенные имидазолы в качестве ингибиторов alk5 и/или alk4 |
| PL3089971T3 (pl) | 2014-01-01 | 2021-01-25 | Medivation Technologies Llc | Związki i sposoby ich zastosowania |
| WO2020012357A1 (en) | 2018-07-10 | 2020-01-16 | Integral Biosciences Pvt. Ltd. | Heterocyclic compounds and methods of use |
-
2021
- 2021-07-14 PT PT217431865T patent/PT4182308T/pt unknown
- 2021-07-14 SI SI202130217T patent/SI4182308T1/sl unknown
- 2021-07-14 WO PCT/EP2021/069649 patent/WO2022013307A1/en not_active Ceased
- 2021-07-14 HR HRP20241617TT patent/HRP20241617T1/hr unknown
- 2021-07-14 ES ES21743186T patent/ES2997111T3/es active Active
- 2021-07-14 DK DK21743186.5T patent/DK4182308T3/da active
- 2021-07-14 FI FIEP21743186.5T patent/FI4182308T3/fi active
- 2021-07-14 CN CN202180061803.6A patent/CN116096719B/zh active Active
- 2021-07-14 KR KR1020237005127A patent/KR20230051500A/ko not_active Withdrawn
- 2021-07-14 US US18/014,764 patent/US12479826B2/en active Active
- 2021-07-14 HU HUE21743186A patent/HUE069150T2/hu unknown
- 2021-07-14 MX MX2023000521A patent/MX2023000521A/es unknown
- 2021-07-14 PL PL21743186.5T patent/PL4182308T3/pl unknown
- 2021-07-14 EP EP21743186.5A patent/EP4182308B1/en active Active
- 2021-07-14 JP JP2023502861A patent/JP7686741B2/ja active Active
- 2021-07-14 AU AU2021307559A patent/AU2021307559A1/en active Pending
- 2021-07-14 BR BR112023000588A patent/BR112023000588A8/pt unknown
- 2021-07-14 CA CA3184990A patent/CA3184990A1/en active Pending
- 2021-07-15 TW TW110126103A patent/TWI914378B/zh active
- 2021-07-15 AR ARP210101996A patent/AR122986A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2997111T3 (en) | 2025-03-19 |
| SI4182308T1 (sl) | 2025-04-30 |
| BR112023000588A8 (pt) | 2023-05-09 |
| MX2023000521A (es) | 2023-02-13 |
| HRP20241617T1 (hr) | 2025-01-31 |
| EP4182308B1 (en) | 2024-09-04 |
| AU2021307559A1 (en) | 2023-02-16 |
| TWI914378B (zh) | 2026-02-11 |
| EP4182308A1 (en) | 2023-05-24 |
| JP2023533849A (ja) | 2023-08-04 |
| DK4182308T3 (da) | 2024-10-21 |
| US20240018122A1 (en) | 2024-01-18 |
| CA3184990A1 (en) | 2022-01-20 |
| WO2022013307A1 (en) | 2022-01-20 |
| CN116096719B (zh) | 2025-09-30 |
| PT4182308T (pt) | 2024-12-04 |
| AR122986A1 (es) | 2022-10-19 |
| US12479826B2 (en) | 2025-11-25 |
| TW202216677A (zh) | 2022-05-01 |
| JP7686741B2 (ja) | 2025-06-02 |
| BR112023000588A2 (pt) | 2023-01-31 |
| CN116096719A (zh) | 2023-05-09 |
| KR20230051500A (ko) | 2023-04-18 |
| HUE069150T2 (hu) | 2025-02-28 |
| FI4182308T3 (fi) | 2024-12-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP4262803A4 (en) | Tetrahydropyridopyrimidine pan-kras inhibitors | |
| EP4216951A4 (en) | KRAS G12D INHIBITORS | |
| IL292643A (en) | Ras inhibitors | |
| IL292644A (en) | Ras inhibitors | |
| IL292642A (en) | Ras inhibitors | |
| IL311840A (en) | Ras inhibitors | |
| PL3697785T3 (pl) | Związki imidazopirydynowe jako inhibitory pad | |
| EP4007752C0 (en) | Kif18a inhibitors | |
| EP4007753C0 (en) | Kif18a inhibitors | |
| EP3768671C0 (en) | SUBSTITUTED IMIDAZOLIDIN-2-ONE DERIVATIVES AS PRMT5 INHIBITORS | |
| EP3898592C0 (en) | HETEROARYL AMIDES USEFUL AS KIF18A INHIBITORS | |
| EP3898616C0 (en) | HETEROARYL AMIDES USEFUL AS KIF18A INHIBITORS | |
| EP4007756C0 (en) | KIF18A INHIBITORS | |
| PL4214202T3 (pl) | Stałe postacie inhibitora CDK4 | |
| DK3768674T3 (da) | Aminopyrimidinderivater som ctps1-hæmmere | |
| PL3870574T3 (pl) | Pochodne aminopirymidyny/pirazyny jako inhibitory CTPS1 | |
| PL4051688T3 (pl) | Inhibitory cd73 | |
| IL269196A (en) | Novel inhibitors | |
| EP3980011A4 (en) | INHIBITORS OF SARM1 | |
| DK3762368T3 (da) | Aminopyrazindiolforbindelser som pi3k-y-inhibitorer | |
| PL4010330T3 (pl) | Pochodne chinoliny jako inhibitory kinazy białkowej | |
| PL3697789T3 (pl) | Skondensowane pochodne imidazolowe podstawione przez trzeciorzędowe grupy hydroksylowe, jako inhibitory pi3k-gamma | |
| DK3952995T3 (da) | Bicykliske heteroarylderivater som ectonukleotidpyrophosphatase-phosphodiesterase-1-hæmmere | |
| DK4182308T3 (da) | Pyridazinylamino-derivater som ALK5-inhibitorer | |
| EP3946288A4 (en) | SUBSTITUTED 5-CYCLOPROPYL-1H-PYRAZOL-3-YL-AMINE DERIVATIVES USED AS SELECTIVE CDK12/13 INHIBITORS |