PL418943A1 - 1'Palmitoyl-2'-(3,7,11-trimethyl-3-vinyldodec-6,10-dienylo)-sn-glycero-3'-phosphocholine and method for obtaining it - Google Patents

1'Palmitoyl-2'-(3,7,11-trimethyl-3-vinyldodec-6,10-dienylo)-sn-glycero-3'-phosphocholine and method for obtaining it

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Publication number
PL418943A1
PL418943A1 PL418943A PL41894316A PL418943A1 PL 418943 A1 PL418943 A1 PL 418943A1 PL 418943 A PL418943 A PL 418943A PL 41894316 A PL41894316 A PL 41894316A PL 418943 A1 PL418943 A1 PL 418943A1
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PL
Poland
Prior art keywords
phosphocholine
glycero
palmitoyl
trimethyl
vinyldodec
Prior art date
Application number
PL418943A
Other languages
Polish (pl)
Other versions
PL231814B1 (en
Inventor
Anna Gliszczyńska
Natalia Niezgoda
Witold Gładkowski
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL418943A priority Critical patent/PL231814B1/en
Publication of PL418943A1 publication Critical patent/PL418943A1/en
Publication of PL231814B1 publication Critical patent/PL231814B1/en

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Abstract

Zgłoszenie dotyczy 1'-palmitoilo-2'-(3,7,11-trimetylo-3-winylododeka-6,10-dienylo)-sn-glicero-3'-fosfocholiny, o wzorze 1, oraz sposobu jej otrzymywania na drodze estryfikacji 1-palmitoilo-sn-glicero-3-fosfocholiny kwasem (E)-3,7,11-trimetylo-3-winylododeka-6,10-dienowym z udziałem czynnika sprzęgającego jakim jest N,N'-dicykloheksylokarbodiimid oraz w obecności 4-dimetyloaminopirydyny w środowisku bezwodnego chlorku metylenu lub chloroformu. Fosfolipid ten może znaleźć zastosowanie w przemyśle farmaceutycznym jako pralek w terapii chorób nowotworowych.The application relates to 1'-palmitoyl-2 '- (3,7,11-trimethyl-3-vinylldodec-6,10-dienyl) -sn-glycero-3'-phosphocholine, of formula 1, and the method of its preparation by esterification 1-palmitoyl-sn-glycero-3-phosphocholine with (E) -3,7,11-trimethyl-3-vinylldodec-6,10-dieneic acid with the participation of a coupling agent which is N, N'-dicyclohexylcarbodiimide and in the presence of 4- dimethylaminopyridine in anhydrous methylene chloride or chloroform. This phospholipid may find application in the pharmaceutical industry as washing machines in the therapy of cancer.

PL418943A 2016-09-30 2016-09-30 1'Palmitoyl-2'-(3,7,11-trimethyl-3-vinyldodec-6,10-dienylo)-sn-glycero-3'-phosphocholine and method for obtaining it PL231814B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL418943A PL231814B1 (en) 2016-09-30 2016-09-30 1'Palmitoyl-2'-(3,7,11-trimethyl-3-vinyldodec-6,10-dienylo)-sn-glycero-3'-phosphocholine and method for obtaining it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL418943A PL231814B1 (en) 2016-09-30 2016-09-30 1'Palmitoyl-2'-(3,7,11-trimethyl-3-vinyldodec-6,10-dienylo)-sn-glycero-3'-phosphocholine and method for obtaining it

Publications (2)

Publication Number Publication Date
PL418943A1 true PL418943A1 (en) 2017-11-20
PL231814B1 PL231814B1 (en) 2019-04-30

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ID=60324444

Family Applications (1)

Application Number Title Priority Date Filing Date
PL418943A PL231814B1 (en) 2016-09-30 2016-09-30 1'Palmitoyl-2'-(3,7,11-trimethyl-3-vinyldodec-6,10-dienylo)-sn-glycero-3'-phosphocholine and method for obtaining it

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PL (1) PL231814B1 (en)

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Publication number Publication date
PL231814B1 (en) 2019-04-30

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