PL4192839T3 - Związki pośrednie remdesiwiru - Google Patents

Związki pośrednie remdesiwiru

Info

Publication number
PL4192839T3
PL4192839T3 PL21756058.0T PL21756058T PL4192839T3 PL 4192839 T3 PL4192839 T3 PL 4192839T3 PL 21756058 T PL21756058 T PL 21756058T PL 4192839 T3 PL4192839 T3 PL 4192839T3
Authority
PL
Poland
Prior art keywords
remdesivir
intermediates
remdesivir intermediates
Prior art date
Application number
PL21756058.0T
Other languages
English (en)
Inventor
István BORZA
Viktor UJVÁRI
Péter BANA
József Levente PETRO
János ÉLES
József BÓDI
Gábor VARRÓ
László János KLADNI
Péter SPRÁNITZ
Balázs KRÁMOS
Original Assignee
Richter Gedeon Nyrt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt. filed Critical Richter Gedeon Nyrt.
Publication of PL4192839T3 publication Critical patent/PL4192839T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
PL21756058.0T 2020-08-06 2021-08-06 Związki pośrednie remdesiwiru PL4192839T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HUP2000258 2020-08-06
HUP2000371 2020-11-10
PCT/IB2021/057242 WO2022029704A1 (en) 2020-08-06 2021-08-06 Remdesivir intermediates

Publications (1)

Publication Number Publication Date
PL4192839T3 true PL4192839T3 (pl) 2026-02-16

Family

ID=89662465

Family Applications (1)

Application Number Title Priority Date Filing Date
PL21756058.0T PL4192839T3 (pl) 2020-08-06 2021-08-06 Związki pośrednie remdesiwiru

Country Status (6)

Country Link
EP (1) EP4192839B1 (pl)
CA (1) CA3185450A1 (pl)
LT (1) LT4192839T (pl)
PL (1) PL4192839T3 (pl)
RS (1) RS67481B1 (pl)
WO (1) WO2022029704A1 (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021214911A1 (en) 2020-01-27 2022-07-21 Gilead Sciences, Inc. Methods for treating SARS CoV-2 infections
CN118994170A (zh) 2020-03-12 2024-11-22 吉利德科学公司 制备1'-氰基核苷的方法
EP4132651B1 (en) 2020-04-06 2026-03-18 Gilead Sciences, Inc. Inhalation formulations of 1'-cyano substituted carbanucleoside analogs
ES3041698T3 (en) 2020-05-29 2025-11-13 Gilead Sciences Inc Remdesivir for the treatment of viral infections
CA3187821A1 (en) 2020-06-24 2021-12-30 Gilead Sciences, Inc. 1'-cyano nucleoside analogs and uses thereof
WO2022047065A2 (en) 2020-08-27 2022-03-03 Gilead Sciences, Inc. Compounds and methods for treatment of viral infections
TW202525810A (zh) 2022-03-02 2025-07-01 美商基利科學股份有限公司 用於治療病毒感染的化合物及方法
CN115521316B (zh) * 2022-09-23 2024-07-26 深圳安泰维生物医药有限公司 一种核苷类化合物或其中间体的制备方法和核苷类化合物的中间体
US12357577B1 (en) 2024-02-02 2025-07-15 Gilead Sciences, Inc. Pharmaceutical formulations and uses thereof
CN116554176A (zh) * 2023-05-11 2023-08-08 南京正济医药研究有限公司 一种核苷类化合物的制备方法
CN117720542B (zh) * 2023-11-01 2026-03-31 南方科技大学坪山生物医药研究院 一种瑞德西韦中间体gs-441524的制备方法
CN121347707B (zh) * 2025-12-19 2026-03-20 湖南尚成生物科技有限公司 瑞德西韦中间体gs-441524的高效液相色谱检测方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5116687B2 (ja) 2005-11-02 2013-01-09 バイエル・ファルマ・アクチェンゲゼルシャフト がんおよび他の過剰増殖性疾患の処置のためのピロロ［２，１−ｆ］［１，２，４］トリアジン−４−イルアミンＩＧＦ−１Ｒキナーゼ阻害剤
HRP20130048T1 (hr) 2008-04-23 2013-02-28 Gilead Sciences, Inc. Karba-nukleozidni analozi za antivirusnu terapiju
ES2524356T3 (es) 2010-07-22 2014-12-05 Gilead Sciences, Inc. Métodos y compuestos para tratar infecciones provocadas por virus Paramyxoviridae
UA119050C2 (uk) 2013-11-11 2019-04-25 Ґілеад Саєнсиз, Інк. ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ
TWI740546B (zh) 2014-10-29 2021-09-21 美商基利科學股份有限公司 製備核糖苷的方法
CN110330540A (zh) 2019-08-08 2019-10-15 木天(济南)生物科技有限公司 核苷盐及其制备方法
CN110776512A (zh) 2019-11-28 2020-02-11 成都傲飞生物化学品有限责任公司 一种核苷类似物的制备方法
CN111205327B (zh) 2020-02-17 2022-05-31 南京法恩化学有限公司 一种瑞德西韦的制备方法
CN111205294B (zh) 2020-02-27 2021-10-01 江苏阿尔法药业股份有限公司 一种瑞德西韦中间体的制备方法
CN111171078B (zh) 2020-02-27 2022-04-22 江苏阿尔法药业股份有限公司 一种瑞德西韦的合成方法
CN111187269A (zh) 2020-02-27 2020-05-22 江苏阿尔法药业有限公司 一种瑞德西韦中间体的合成方法
CN111116656A (zh) 2020-03-04 2020-05-08 江苏福瑞康泰药业有限公司 一种瑞德西韦的制备方法
CN111233930B (zh) 2020-03-04 2022-05-13 江苏阿尔法药业股份有限公司 一种瑞德西韦的制备方法
CN111269263A (zh) 2020-03-09 2020-06-12 上海龙翔生物医药开发有限公司 一种瑞德西韦侧链中间体及其制备方法
CN111233870A (zh) 2020-03-11 2020-06-05 中国科学技术大学 用于快速制备瑞德西韦药物中间体的方法
CN111233869B (zh) 2020-03-12 2022-09-16 杭州新博思生物医药有限公司 用于制备瑞德西韦关键中间体的新化合物及其制备方法
CN111393478B (zh) 2020-03-13 2023-05-26 深圳市宝安区新材料研究院 一种瑞德西韦的合成方法
CN111233931B (zh) 2020-03-26 2022-03-22 宿迁盛基医药科技有限公司 一种瑞德西韦的合成方法
CN111471070B (zh) 2020-04-26 2022-05-13 江苏阿尔法药业股份有限公司 瑞德西韦的合成方法
CN111440176B (zh) 2020-04-28 2022-04-26 江苏大学 金属配合物促进的瑞德西韦中间体的合成方法
CN111620876B (zh) 2020-05-07 2021-09-28 普济生物科技（台州）有限公司 瑞德西韦关键中间体的合成方法
CN111393392A (zh) 2020-05-07 2020-07-10 河南省科学院高新技术研究中心 瑞德西韦关键中间体2,3,5-三苄氧基-d-核糖酸-1,4-内酯的合成
CN111620903A (zh) 2020-06-17 2020-09-04 安徽贝克联合制药有限公司 C-核苷类似物以及用于合成瑞德西韦合成的含腈c-核苷类化合物的制备方法及其应用

Also Published As

Publication number Publication date
CA3185450A1 (en) 2022-02-10
EP4192839B1 (en) 2025-10-01
LT4192839T (lt) 2025-11-25
WO2022029704A1 (en) 2022-02-10
RS67481B1 (sr) 2025-12-31
EP4192839A1 (en) 2023-06-14

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