PL4204570T3 - Sposób wytwarzania rekombinownego białka w komórce gospodarza z zablokowanym metabolizmem ramnozy oraz wektory ekspresyjne, komórki gospodarza i ich rekombinowane białka - Google Patents

Sposób wytwarzania rekombinownego białka w komórce gospodarza z zablokowanym metabolizmem ramnozy oraz wektory ekspresyjne, komórki gospodarza i ich rekombinowane białka

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Publication number
PL4204570T3
PL4204570T3 PL21790425.9T PL21790425T PL4204570T3 PL 4204570 T3 PL4204570 T3 PL 4204570T3 PL 21790425 T PL21790425 T PL 21790425T PL 4204570 T3 PL4204570 T3 PL 4204570T3
Authority
PL
Poland
Prior art keywords
disabled
producing
well
expression vectors
host cell
Prior art date
Application number
PL21790425.9T
Other languages
English (en)
Inventor
David VIKSTRÖM
Nurzian ISMAIL
Patrik SAMUELSON
Kiavash MIRZADEH
Santhosh GUDISE
Maria KADOW
Kathleen SZEKÉR
Tagrid SALIH
Mariusz BARASZKIEWICZ
Siavash BASHIRI
Original Assignee
Stada Arzneimittel Ag
Xbrane Biopharma Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stada Arzneimittel Ag, Xbrane Biopharma Ab filed Critical Stada Arzneimittel Ag
Publication of PL4204570T3 publication Critical patent/PL4204570T3/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
PL21790425.9T 2020-10-09 2021-10-08 Sposób wytwarzania rekombinownego białka w komórce gospodarza z zablokowanym metabolizmem ramnozy oraz wektory ekspresyjne, komórki gospodarza i ich rekombinowane białka PL4204570T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20201096.3A EP3981879A1 (en) 2020-10-09 2020-10-09 Method of producing a recombinant protein in a host cell which has a disabled rhamnose metabolism as well as expression vectors, host cells and recombinant proteins thereof
PCT/EP2021/077820 WO2022074182A1 (en) 2020-10-09 2021-10-08 Method of producing a recombinant protein in a host cell which has a disabled rhamnose metabolism as well as expression vectors, host cells and recombinant proteins thereof

Publications (1)

Publication Number Publication Date
PL4204570T3 true PL4204570T3 (pl) 2025-10-06

Family

ID=72826766

Family Applications (1)

Application Number Title Priority Date Filing Date
PL21790425.9T PL4204570T3 (pl) 2020-10-09 2021-10-08 Sposób wytwarzania rekombinownego białka w komórce gospodarza z zablokowanym metabolizmem ramnozy oraz wektory ekspresyjne, komórki gospodarza i ich rekombinowane białka

Country Status (15)

Country Link
US (1) US20230340096A1 (pl)
EP (2) EP3981879A1 (pl)
JP (1) JP2023549432A (pl)
KR (1) KR20230079228A (pl)
CN (1) CN116323950A (pl)
AU (1) AU2021357360A1 (pl)
CA (1) CA3193217A1 (pl)
ES (1) ES3036687T3 (pl)
GE (2) GEP20247669B (pl)
IL (1) IL301642A (pl)
JO (1) JOP20230064A1 (pl)
MX (1) MX2023003819A (pl)
PL (1) PL4204570T3 (pl)
WO (1) WO2022074182A1 (pl)
ZA (1) ZA202303775B (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024534603A (ja) * 2021-09-24 2024-09-20 エックスブレイン バイオファーマ エービー 組換えタンパク質を発現させるためのｄｎａ構築物及び宿主細胞

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8293503B2 (en) * 2003-10-03 2012-10-23 Promega Corporation Vectors for directional cloning
EP2123761A3 (en) * 2004-12-07 2009-12-16 Lonza Ag Rhamnose promoter expression system
WO2009106635A1 (en) 2008-02-29 2009-09-03 Xbrane Bioscience Aktiebolag Expression system for proteins
EP3031894A1 (en) * 2008-11-11 2016-06-15 Danisco US Inc. Proteases comprising one or more combinable mutations
CA2811699C (en) * 2010-09-28 2019-07-02 Abera Bioscience Ab Fusion protein for secretory protein expression
CN110636859B (zh) * 2017-05-19 2024-05-03 科学与工业研究委员会 用于产生重折叠的重组人源化兰尼单抗的方法

Also Published As

Publication number Publication date
AU2021357360A1 (en) 2023-05-04
US20230340096A1 (en) 2023-10-26
WO2022074182A1 (en) 2022-04-14
MX2023003819A (es) 2023-08-16
ZA202303775B (en) 2025-07-30
EP4204570C0 (en) 2025-06-04
GEAP202416228A (en) 2024-05-13
GEP20247669B (en) 2024-09-25
EP3981879A1 (en) 2022-04-13
AU2021357360A9 (en) 2023-07-06
ES3036687T3 (en) 2025-09-23
EP4204570A1 (en) 2023-07-05
KR20230079228A (ko) 2023-06-05
JOP20230064A1 (ar) 2023-03-28
EP4204570B1 (en) 2025-06-04
CN116323950A (zh) 2023-06-23
IL301642A (en) 2023-05-01
JP2023549432A (ja) 2023-11-24
CA3193217A1 (en) 2022-04-14
WO2022074182A9 (en) 2022-06-16

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