PL420762A1 - Sposób wytwarzania kompozytowych implantów kostnych, sposób wytwarzania sproszkowanego surowca na kompozytowe implanty kostne, sproszkowany surowiec na implanty kostne i kompozytowy implant kostny - Google Patents
Sposób wytwarzania kompozytowych implantów kostnych, sposób wytwarzania sproszkowanego surowca na kompozytowe implanty kostne, sproszkowany surowiec na implanty kostne i kompozytowy implant kostnyInfo
- Publication number
- PL420762A1 PL420762A1 PL420762A PL42076217A PL420762A1 PL 420762 A1 PL420762 A1 PL 420762A1 PL 420762 A PL420762 A PL 420762A PL 42076217 A PL42076217 A PL 42076217A PL 420762 A1 PL420762 A1 PL 420762A1
- Authority
- PL
- Poland
- Prior art keywords
- raw material
- implant
- composite bone
- bone implants
- producing
- Prior art date
Links
- 239000007943 implant Substances 0.000 title abstract 11
- 239000002994 raw material Substances 0.000 title abstract 7
- 210000000988 bone and bone Anatomy 0.000 title abstract 6
- 239000002131 composite material Substances 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 4
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 2
- 239000011575 calcium Substances 0.000 abstract 2
- 229910052791 calcium Inorganic materials 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 239000011574 phosphorus Substances 0.000 abstract 2
- 229910052698 phosphorus Inorganic materials 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- 108010022355 Fibroins Proteins 0.000 abstract 1
- 239000000835 fiber Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Composite Materials (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Materials For Medical Uses (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób wytwarzania implantów, który zawiera etap przygotowania surowca w postaci sproszkowanej oraz etap formowania z niego implantu poprzez prasowanie. W etapie przygotowania surowca jednocześnie kriogenicznie rozdrabnia się odcinki włókna naturalnego jedwabiu i miesza się je ze sproszkowanym syntetycznym nanometrycznym hydroksyapatytem. Udział hydroksyapatytu w sproszkowanym surowcu wynosi od 70% do 95% wagowo. Proszek kompozytowy będący surowcem do formowania implantu, zawiera hydroksyapatyt o rozmiarze cząstek nie większym niż 80 nm i stosunku molowym wapnia do fosforu z zakresu od 1,57 do 1,67. Kompozytowy implant kostny zawiera fibroinę oraz od 70% do 95% wagowo hydroksyapatytu o rozmiarze cząstek nie większym niż 80 nm i stosunku molowym wapnia do fosforu zakresu od 1,57 do 1,65. Moduł Younga materiału tego implantu mieści się w zakresie od 7,5 do 9,5 GPa, jego porowatość całkowita mieści się w zakresie od 10 do 20%. Wytrzymałość na zginanie takiego implantu wynosi co najmniej 30 MPa, a jego wytrzymałość na ściskanie wynosi co najmniej 100 MPa. Zgłoszenie to obejmuje też kompozytowy implant kostny oraz sproszkowany surowiec.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL420762A PL244595B1 (pl) | 2017-03-07 | 2017-03-07 | Sposób wytwarzania kompozytowych implantów kostnych, sposób wytwarzania sproszkowanego surowca na kompozytowe implanty kostne, sproszkowany surowiec na implanty kostne i kompozytowy implant kostny |
| PCT/PL2018/050008 WO2018164594A1 (en) | 2017-03-07 | 2018-03-05 | Method of manufacturing composite bone implants, method of manufacturing powdered raw material for such implants, such powdered raw material and bone implant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL420762A PL244595B1 (pl) | 2017-03-07 | 2017-03-07 | Sposób wytwarzania kompozytowych implantów kostnych, sposób wytwarzania sproszkowanego surowca na kompozytowe implanty kostne, sproszkowany surowiec na implanty kostne i kompozytowy implant kostny |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL420762A1 true PL420762A1 (pl) | 2018-09-10 |
| PL244595B1 PL244595B1 (pl) | 2024-02-12 |
Family
ID=62063137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL420762A PL244595B1 (pl) | 2017-03-07 | 2017-03-07 | Sposób wytwarzania kompozytowych implantów kostnych, sposób wytwarzania sproszkowanego surowca na kompozytowe implanty kostne, sproszkowany surowiec na implanty kostne i kompozytowy implant kostny |
Country Status (2)
| Country | Link |
|---|---|
| PL (1) | PL244595B1 (pl) |
| WO (1) | WO2018164594A1 (pl) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111849013A (zh) * | 2020-07-14 | 2020-10-30 | 重庆医科大学附属口腔医院 | 一种纳米羟基磷灰石-丝素蛋白矿化支架及其制备方法和用途 |
| CN116262147A (zh) * | 2021-12-15 | 2023-06-16 | 西湖大学 | 丝蛋白/生物陶瓷复合材料及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL221445B1 (pl) * | 2012-06-27 | 2016-04-29 | Inst Wysokich Ciśnień Polskiej Akademii Nauk | Sposób wytwarzania implantów kostnych |
| US10080644B2 (en) * | 2013-07-19 | 2018-09-25 | National University Of Singapore | Tissue interface augmentation device for ligament/tendon reconstruction |
-
2017
- 2017-03-07 PL PL420762A patent/PL244595B1/pl unknown
-
2018
- 2018-03-05 WO PCT/PL2018/050008 patent/WO2018164594A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| PL244595B1 (pl) | 2024-02-12 |
| WO2018164594A1 (en) | 2018-09-13 |
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