PL4210709T3 - 2’,3’–diacetylurydyna podstawiona acetoacetylem w pozycji 5’ - Google Patents
2’,3’–diacetylurydyna podstawiona acetoacetylem w pozycji 5’Info
- Publication number
- PL4210709T3 PL4210709T3 PL21867793.8T PL21867793T PL4210709T3 PL 4210709 T3 PL4210709 T3 PL 4210709T3 PL 21867793 T PL21867793 T PL 21867793T PL 4210709 T3 PL4210709 T3 PL 4210709T3
- Authority
- PL
- Poland
- Prior art keywords
- diacetyluridine
- acetoacetyl
- substituted
- diacetyluridine substituted
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063077760P | 2020-09-14 | 2020-09-14 | |
| US202163188559P | 2021-05-14 | 2021-05-14 | |
| US202163227611P | 2021-07-30 | 2021-07-30 | |
| US202163231825P | 2021-08-11 | 2021-08-11 | |
| PCT/US2021/050149 WO2022056428A1 (en) | 2020-09-14 | 2021-09-14 | 2',3'-diacetyluridine substituted with acetoacetyl at the 5' position |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL4210709T3 true PL4210709T3 (pl) | 2026-03-30 |
Family
ID=80629921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL21867793.8T PL4210709T3 (pl) | 2020-09-14 | 2021-09-14 | 2’,3’–diacetylurydyna podstawiona acetoacetylem w pozycji 5’ |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US12577270B2 (pl) |
| EP (2) | EP4210709B1 (pl) |
| JP (1) | JP2023541919A (pl) |
| KR (1) | KR20230067613A (pl) |
| CN (1) | CN116157133A (pl) |
| AU (1) | AU2021340882A1 (pl) |
| CA (1) | CA3191547A1 (pl) |
| DK (1) | DK4210709T3 (pl) |
| ES (1) | ES3060948T3 (pl) |
| FI (1) | FI4210709T3 (pl) |
| HR (1) | HRP20260127T1 (pl) |
| IL (1) | IL300902A (pl) |
| LT (1) | LT4210709T (pl) |
| MX (1) | MX2023002868A (pl) |
| PL (1) | PL4210709T3 (pl) |
| PT (1) | PT4210709T (pl) |
| RS (1) | RS67725B1 (pl) |
| SI (1) | SI4210709T1 (pl) |
| SM (1) | SMT202600044T1 (pl) |
| WO (1) | WO2022056428A1 (pl) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT4210709T (pt) | 2020-09-14 | 2026-02-04 | Pharma Cinq Llc | 2¿,3¿‐diacetiluridina substituída com acetoacetilo na posição 5¿ |
| US20250262189A1 (en) * | 2022-04-22 | 2025-08-21 | Rdiscovery, LLC | Treatment of diseases associated with reductive stress |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4992534A (en) | 1987-08-12 | 1991-02-12 | Otsuka Pharmaceutical Co., Ltd. | 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine |
| US5968914A (en) * | 1987-10-28 | 1999-10-19 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
| JP2526414B2 (ja) | 1994-05-20 | 1996-08-21 | 工業技術院長 | 制ガン剤エステル化合物及びその製造方法 |
| JP4408450B2 (ja) | 1994-07-01 | 2010-02-03 | ウェルスタット セラピューティクス コーポレイション | 全身性炎症および炎症性肝炎の処置のためのピリミジンヌクレオチド前駆体 |
| US6472378B2 (en) | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
| US7915233B1 (en) | 1998-08-31 | 2011-03-29 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
| EP1808177B1 (en) * | 1999-02-23 | 2018-08-08 | The Regents of The University of California | Methods of treatment of mitochondrial disorders |
| US6992219B2 (en) | 2002-08-09 | 2006-01-31 | Cephalon France | Modafinil polymorphic forms |
| JP2007510734A (ja) | 2003-11-07 | 2007-04-26 | ザ ヘンリー エム． ジャクソン ファウンデイション | 低酸素誘導性遺伝子発現の活性化 |
| SI2153870T1 (sl) | 2004-11-26 | 2014-05-30 | Ucl Business Plc | Sestavki, ki obsegajo ornitin in fenilacetat ali fenilbutirat, za zdravljenje hepatitične encefalopatije |
| KR100818202B1 (ko) | 2006-12-22 | 2008-03-31 | 한국과학기술원 | 미생물의 성장에 필수적인 대사산물의 스크리닝 방법 |
| RU2631597C2 (ru) | 2011-07-15 | 2017-09-25 | Нусерт Сайенсиз, Инк. | Композиции и способы модулирования метаболических путей |
| PT2922576T (pt) | 2012-11-21 | 2018-01-24 | Horizon Therapeutics Llc | Métodos de administração e avaliação de fármacos sequestradores de azoto para o tratamento de encefalopatia hepática |
| SI2968385T1 (sl) | 2013-03-13 | 2018-10-30 | Tufts University | Uridin nukleozid derivati, sestavki in metode uporabe |
| PL3182980T3 (pl) | 2014-08-19 | 2021-04-19 | Wellstat Therapeutics Corporation | Leczenie chorób niedoboru glikozylacji |
| WO2017070445A1 (en) | 2015-10-23 | 2017-04-27 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Methods of treatment of rhabdomyolysis |
| RU2659388C1 (ru) | 2017-02-28 | 2018-07-02 | Васильевич Иващенко Александр | Нуклеотиды, включающие N-[(S)-1-циклобутоксикарбонил]фосфорамидатный фрагмент, их аналоги и их применение |
| AU2019215105B2 (en) | 2018-02-01 | 2024-12-19 | Pharma Cinq, Llc | Compositions and devices for systemic delivery of uridine |
| PT4210709T (pt) | 2020-09-14 | 2026-02-04 | Pharma Cinq Llc | 2¿,3¿‐diacetiluridina substituída com acetoacetilo na posição 5¿ |
| WO2022089612A1 (zh) | 2020-10-30 | 2022-05-05 | 上海岸阔医药科技有限公司 | 尿苷衍生物在制备药物中的应用 |
| US20230416292A1 (en) | 2020-12-01 | 2023-12-28 | Wellstat Therapeutics Corporation | 5'-O-Phenylacetyluridine and therapeutic use |
| WO2022177740A1 (en) | 2021-02-21 | 2022-08-25 | Wellstat Therapeutics Corporation | Compositions and compounds for co-delivery of uridine and ketoleucine |
-
2021
- 2021-09-14 PT PT218677938T patent/PT4210709T/pt unknown
- 2021-09-14 MX MX2023002868A patent/MX2023002868A/es unknown
- 2021-09-14 KR KR1020237008514A patent/KR20230067613A/ko active Pending
- 2021-09-14 CN CN202180061982.3A patent/CN116157133A/zh active Pending
- 2021-09-14 AU AU2021340882A patent/AU2021340882A1/en active Pending
- 2021-09-14 US US18/021,907 patent/US12577270B2/en active Active
- 2021-09-14 EP EP21867793.8A patent/EP4210709B1/en active Active
- 2021-09-14 SM SM20260044T patent/SMT202600044T1/it unknown
- 2021-09-14 ES ES21867793T patent/ES3060948T3/es active Active
- 2021-09-14 EP EP25197732.8A patent/EP4667478A1/en active Pending
- 2021-09-14 JP JP2023516668A patent/JP2023541919A/ja active Pending
- 2021-09-14 LT LTEPPCT/US2021/050149T patent/LT4210709T/lt unknown
- 2021-09-14 RS RS20260110A patent/RS67725B1/sr unknown
- 2021-09-14 HR HRP20260127TT patent/HRP20260127T1/hr unknown
- 2021-09-14 FI FIEP21867793.8T patent/FI4210709T3/fi active
- 2021-09-14 SI SI202130386T patent/SI4210709T1/sl unknown
- 2021-09-14 IL IL300902A patent/IL300902A/en unknown
- 2021-09-14 WO PCT/US2021/050149 patent/WO2022056428A1/en not_active Ceased
- 2021-09-14 PL PL21867793.8T patent/PL4210709T3/pl unknown
- 2021-09-14 CA CA3191547A patent/CA3191547A1/en active Pending
- 2021-09-14 DK DK21867793.8T patent/DK4210709T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| SI4210709T1 (sl) | 2026-03-31 |
| EP4667478A1 (en) | 2025-12-24 |
| JP2023541919A (ja) | 2023-10-04 |
| EP4210709B1 (en) | 2025-10-29 |
| CN116157133A (zh) | 2023-05-23 |
| EP4210709A1 (en) | 2023-07-19 |
| US12577270B2 (en) | 2026-03-17 |
| ES3060948T3 (en) | 2026-03-30 |
| WO2022056428A1 (en) | 2022-03-17 |
| KR20230067613A (ko) | 2023-05-16 |
| CA3191547A1 (en) | 2022-03-17 |
| PT4210709T (pt) | 2026-02-04 |
| IL300902A (en) | 2023-04-01 |
| AU2021340882A1 (en) | 2023-05-25 |
| MX2023002868A (es) | 2023-03-24 |
| FI4210709T3 (fi) | 2026-01-30 |
| DK4210709T3 (en) | 2026-02-02 |
| HRP20260127T1 (hr) | 2026-03-13 |
| US20230357304A1 (en) | 2023-11-09 |
| LT4210709T (lt) | 2026-02-25 |
| RS67725B1 (sr) | 2026-03-31 |
| SMT202600044T1 (it) | 2026-03-09 |
| AU2021340882A9 (en) | 2025-03-20 |
| EP4210709A4 (en) | 2024-09-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UA45061S (uk) | 1. футляр | |
| JP2020089354A5 (pl) | ||
| JP2020104561A5 (pl) | ||
| JP2020117155A5 (pl) | ||
| EP4085145A4 (en) | Guided excision-transposition systems | |
| PL4210709T3 (pl) | 2’,3’–diacetylurydyna podstawiona acetoacetylem w pozycji 5’ | |
| JP2019207083A5 (pl) | ||
| JP2020111415A5 (pl) | ||
| JPWO2021090688A5 (pl) | ||
| JP2023056214A5 (pl) | ||
| JP2020096470A5 (pl) | ||
| EP3880998A4 (en) | EXTENDED AREA ENCAPSULATION SHELL | |
| JP2021197754A5 (pl) | ||
| JP2020120593A5 (pl) | ||
| EP3777627C0 (en) | A urine deflector | |
| JP2021062015A5 (pl) | ||
| JP2020140345A5 (pl) | ||
| JP2020084867A5 (pl) | ||
| JP2020141262A5 (pl) | ||
| JP2019183589A5 (pl) | ||
| EP4039631A4 (en) | TENSIONING ANCHOR | |
| UA44929S (uk) | 1. поштомат з функцією охолодження | |
| UA44832S (uk) | 1. логотип | |
| JP2021076236A5 (pl) | ||
| UA45174S (uk) | 1. інтер'єр магазину |