PL4210709T3 - 2’,3’–diacetylurydyna podstawiona acetoacetylem w pozycji 5’ - Google Patents
2’,3’–diacetylurydyna podstawiona acetoacetylem w pozycji 5’Info
- Publication number
- PL4210709T3 PL4210709T3 PL21867793.8T PL21867793T PL4210709T3 PL 4210709 T3 PL4210709 T3 PL 4210709T3 PL 21867793 T PL21867793 T PL 21867793T PL 4210709 T3 PL4210709 T3 PL 4210709T3
- Authority
- PL
- Poland
- Prior art keywords
- diacetyluridine
- acetoacetyl
- substituted
- diacetyluridine substituted
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063077760P | 2020-09-14 | 2020-09-14 | |
| US202163188559P | 2021-05-14 | 2021-05-14 | |
| US202163227611P | 2021-07-30 | 2021-07-30 | |
| US202163231825P | 2021-08-11 | 2021-08-11 | |
| PCT/US2021/050149 WO2022056428A1 (en) | 2020-09-14 | 2021-09-14 | 2',3'-diacetyluridine substituted with acetoacetyl at the 5' position |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL4210709T3 true PL4210709T3 (pl) | 2026-03-30 |
Family
ID=80629921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL21867793.8T PL4210709T3 (pl) | 2020-09-14 | 2021-09-14 | 2’,3’–diacetylurydyna podstawiona acetoacetylem w pozycji 5’ |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US12577270B2 (pl) |
| EP (2) | EP4667478A1 (pl) |
| JP (1) | JP7876512B2 (pl) |
| KR (1) | KR20230067613A (pl) |
| CN (1) | CN116157133A (pl) |
| AU (1) | AU2021340882A1 (pl) |
| CA (1) | CA3191547A1 (pl) |
| DK (1) | DK4210709T3 (pl) |
| ES (1) | ES3060948T3 (pl) |
| FI (1) | FI4210709T3 (pl) |
| HR (1) | HRP20260127T1 (pl) |
| IL (1) | IL300902A (pl) |
| LT (1) | LT4210709T (pl) |
| MX (1) | MX2023002868A (pl) |
| PL (1) | PL4210709T3 (pl) |
| PT (1) | PT4210709T (pl) |
| RS (1) | RS67725B1 (pl) |
| SI (1) | SI4210709T1 (pl) |
| SM (1) | SMT202600044T1 (pl) |
| WO (1) | WO2022056428A1 (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES3060948T3 (en) | 2020-09-14 | 2026-03-30 | Pharma Cinq Llc | 2',3'-diacetyluridine substituted with acetoacetyl at the 5' position |
| DK4255563T3 (da) | 2020-12-01 | 2026-03-16 | Pharma Cinq Llc | 5´-o-phenylacetyluridin og terapeutisk anvendelse |
| EP4294405A4 (en) | 2021-02-21 | 2025-01-29 | Pharma Cinq, LLC | COMPOSITIONS AND COMPOUNDS FOR CO-ADMINISTRATION OF URIDINE AND KETOLEUCINE |
| US20250262189A1 (en) * | 2022-04-22 | 2025-08-21 | Rdiscovery, LLC | Treatment of diseases associated with reductive stress |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4992534A (en) | 1987-08-12 | 1991-02-12 | Otsuka Pharmaceutical Co., Ltd. | 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine |
| US5968914A (en) | 1987-10-28 | 1999-10-19 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
| JP2526414B2 (ja) | 1994-05-20 | 1996-08-21 | 工業技術院長 | 制ガン剤エステル化合物及びその製造方法 |
| CN101066276A (zh) | 1994-07-01 | 2007-11-07 | 威尔斯塔特医疗公司 | 用于治疗全身性炎症和炎性肝炎的嘧啶核苷酸前体 |
| US7915233B1 (en) | 1998-08-31 | 2011-03-29 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
| US6472378B2 (en) | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
| BR0008447A (pt) | 1999-02-23 | 2002-01-15 | Univ California | Métodos de tratamento de distúrbios mitocondriais |
| US6992219B2 (en) | 2002-08-09 | 2006-01-31 | Cephalon France | Modafinil polymorphic forms |
| WO2005094236A2 (en) | 2003-11-07 | 2005-10-13 | Henry M. Jackson Foundation | Activation of hypoxia-inducible gene expression |
| PT2319581E (pt) | 2004-11-26 | 2015-06-30 | Ucl Business Plc | Composições compreendendo ornitina e fenilacetato ou fenilbutirato para tratamento de encefalopatia hepática |
| KR100818202B1 (ko) | 2006-12-22 | 2008-03-31 | 한국과학기술원 | 미생물의 성장에 필수적인 대사산물의 스크리닝 방법 |
| MX2014000419A (es) | 2011-07-15 | 2014-09-22 | Nusirt Sciences Inc | Composicones y metodos para modular trayectorias metabolicas. |
| HUE036133T2 (hu) | 2012-11-21 | 2018-06-28 | Horizon Therapeutics Llc | Eljárások hepatikus enkefalopátia kezelésére szolgáló nitrogénelvonó gyógyszerek beadására és értékelésére |
| PL2968385T3 (pl) | 2013-03-13 | 2019-05-31 | Univ Tufts | Pochodne nukleozydów urydynowych, kompozycje i sposoby zastosowania |
| US20170209476A1 (en) * | 2014-08-19 | 2017-07-27 | Wellstat Therapeutics Corporation | Treatment of Glycosylation Deficiency Diseases |
| US20180318381A1 (en) | 2015-10-23 | 2018-11-08 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Methods of Treatment of Rhabdomyolysis |
| RU2659388C1 (ru) | 2017-02-28 | 2018-07-02 | Васильевич Иващенко Александр | Нуклеотиды, включающие N-[(S)-1-циклобутоксикарбонил]фосфорамидатный фрагмент, их аналоги и их применение |
| IL276236B2 (en) * | 2018-02-01 | 2025-12-01 | Wellstat Therapeutics Corp | Compositions and devices comprising uridine and the d enantiomer of beta-hydroxybutyrate and a cationic counterion |
| ES3060948T3 (en) | 2020-09-14 | 2026-03-30 | Pharma Cinq Llc | 2',3'-diacetyluridine substituted with acetoacetyl at the 5' position |
| CN116437930A (zh) | 2020-10-30 | 2023-07-14 | 上海岸阔医药科技有限公司 | 尿苷衍生物在制备药物中的应用 |
| DK4255563T3 (da) | 2020-12-01 | 2026-03-16 | Pharma Cinq Llc | 5´-o-phenylacetyluridin og terapeutisk anvendelse |
| EP4294405A4 (en) | 2021-02-21 | 2025-01-29 | Pharma Cinq, LLC | COMPOSITIONS AND COMPOUNDS FOR CO-ADMINISTRATION OF URIDINE AND KETOLEUCINE |
-
2021
- 2021-09-14 ES ES21867793T patent/ES3060948T3/es active Active
- 2021-09-14 CN CN202180061982.3A patent/CN116157133A/zh active Pending
- 2021-09-14 HR HRP20260127TT patent/HRP20260127T1/hr unknown
- 2021-09-14 US US18/021,907 patent/US12577270B2/en active Active
- 2021-09-14 PT PT218677938T patent/PT4210709T/pt unknown
- 2021-09-14 LT LTEPPCT/US2021/050149T patent/LT4210709T/lt unknown
- 2021-09-14 KR KR1020237008514A patent/KR20230067613A/ko active Pending
- 2021-09-14 WO PCT/US2021/050149 patent/WO2022056428A1/en not_active Ceased
- 2021-09-14 AU AU2021340882A patent/AU2021340882A1/en active Pending
- 2021-09-14 CA CA3191547A patent/CA3191547A1/en active Pending
- 2021-09-14 EP EP25197732.8A patent/EP4667478A1/en active Pending
- 2021-09-14 IL IL300902A patent/IL300902A/en unknown
- 2021-09-14 RS RS20260110A patent/RS67725B1/sr unknown
- 2021-09-14 MX MX2023002868A patent/MX2023002868A/es unknown
- 2021-09-14 EP EP21867793.8A patent/EP4210709B1/en active Active
- 2021-09-14 DK DK21867793.8T patent/DK4210709T3/da active
- 2021-09-14 JP JP2023516668A patent/JP7876512B2/ja active Active
- 2021-09-14 PL PL21867793.8T patent/PL4210709T3/pl unknown
- 2021-09-14 SI SI202130386T patent/SI4210709T1/sl unknown
- 2021-09-14 FI FIEP21867793.8T patent/FI4210709T3/fi active
- 2021-09-14 SM SM20260044T patent/SMT202600044T1/it unknown
-
2026
- 2026-02-12 US US19/537,857 patent/US20260159541A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2023002868A (es) | 2023-03-24 |
| JP7876512B2 (ja) | 2026-06-19 |
| US20260159541A1 (en) | 2026-06-11 |
| EP4667478A1 (en) | 2025-12-24 |
| KR20230067613A (ko) | 2023-05-16 |
| EP4210709A1 (en) | 2023-07-19 |
| JP2023541919A (ja) | 2023-10-04 |
| EP4210709A4 (en) | 2024-09-04 |
| IL300902A (en) | 2023-04-01 |
| AU2021340882A1 (en) | 2023-05-25 |
| SI4210709T1 (sl) | 2026-03-31 |
| FI4210709T3 (fi) | 2026-01-30 |
| US12577270B2 (en) | 2026-03-17 |
| DK4210709T3 (en) | 2026-02-02 |
| AU2021340882A9 (en) | 2025-03-20 |
| CA3191547A1 (en) | 2022-03-17 |
| PT4210709T (pt) | 2026-02-04 |
| US20230357304A1 (en) | 2023-11-09 |
| LT4210709T (lt) | 2026-02-25 |
| EP4210709B1 (en) | 2025-10-29 |
| RS67725B1 (sr) | 2026-03-31 |
| SMT202600044T1 (it) | 2026-03-09 |
| WO2022056428A1 (en) | 2022-03-17 |
| HRP20260127T1 (hr) | 2026-03-13 |
| CN116157133A (zh) | 2023-05-23 |
| ES3060948T3 (en) | 2026-03-30 |
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