PL421982A1 - Method for producing 1,2-di-[2'-(4''-isobutylphenyl)]propanoyl-sn-glycero-3-phosphocholine - Google Patents
Method for producing 1,2-di-[2'-(4''-isobutylphenyl)]propanoyl-sn-glycero-3-phosphocholineInfo
- Publication number
- PL421982A1 PL421982A1 PL421982A PL42198217A PL421982A1 PL 421982 A1 PL421982 A1 PL 421982A1 PL 421982 A PL421982 A PL 421982A PL 42198217 A PL42198217 A PL 42198217A PL 421982 A1 PL421982 A1 PL 421982A1
- Authority
- PL
- Poland
- Prior art keywords
- phosphocholine
- glycero
- isobutylphenyl
- propanoyl
- producing
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 2
- YKYOUMDCQGMQQO-UHFFFAOYSA-L cadmium dichloride Chemical compound Cl[Cd]Cl YKYOUMDCQGMQQO-UHFFFAOYSA-L 0.000 abstract 2
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 abstract 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- SUHOQUVVVLNYQR-MRVPVSSYSA-O glycerylphosphorylcholine Chemical compound C[N+](C)(C)CCO[P@](O)(=O)OC[C@H](O)CO SUHOQUVVVLNYQR-MRVPVSSYSA-O 0.000 abstract 1
- 229960001680 ibuprofen Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000012299 nitrogen atmosphere Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób otrzymywania 1,2-di-[2'-(4-izobutylofenylo)]propanoilo-sn-glicero-3-fosfocholiny o wzorze 3, gdzie kompleks sn-glicero-3-fosfocholiny z chlorkiem kadmu poddaje się estryfikacji ibuprofenem w bezwodnym chlorku metylenu lub chloroformie, w obecności 4-(N,N-dimetyloamino)pirydyny z udziałem N,N'-dicykloheksylokarbodiimidu jako odczynnika sprzęgającego, a reakcję prowadzi się w atmosferze N2 przez co najmniej 48 godzin."The subject of the application is a method for obtaining 1,2-di-[2'-(4-isobutylphenyl)]propanoyl-sn-glycero-3-phosphocholine of formula 3, where the complex of sn-glycero-3-phosphocholine with cadmium chloride is esterified with ibuprofen in anhydrous methylene chloride or chloroform, in the presence of 4-(N,N-dimethylamino)pyridine with N,N'-dicyclohexylcarbodiimide as a coupling reagent, and the reaction is carried out in an N2 atmosphere for at least 48 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL421982A PL238966B1 (en) | 2017-06-22 | 2017-06-22 | Method for producing 1,2-di-[2'-(4''-isobutylphenyl)]propanoyl-sn-glycero-3-phosphocholine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL421982A PL238966B1 (en) | 2017-06-22 | 2017-06-22 | Method for producing 1,2-di-[2'-(4''-isobutylphenyl)]propanoyl-sn-glycero-3-phosphocholine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL421982A1 true PL421982A1 (en) | 2019-01-02 |
| PL238966B1 PL238966B1 (en) | 2021-10-25 |
Family
ID=64899002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL421982A PL238966B1 (en) | 2017-06-22 | 2017-06-22 | Method for producing 1,2-di-[2'-(4''-isobutylphenyl)]propanoyl-sn-glycero-3-phosphocholine |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL238966B1 (en) |
-
2017
- 2017-06-22 PL PL421982A patent/PL238966B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL238966B1 (en) | 2021-10-25 |
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