PL418654A1 - 1',2'-Di{2-[(2''E)-2''-butylidene-1'',3'',3''-trimethyl]cyclohexyl}acetyl-sn-glycero-3'-phosphocholine and method for obtaining 1',2'-di{2-[(2''E)-2''-butylidene-1'',3'',3''-trimethyl]cyclohexyl}acetyl-sn-glycero-3'-phosphocholine - Google Patents

1',2'-Di{2-[(2''E)-2''-butylidene-1'',3'',3''-trimethyl]cyclohexyl}acetyl-sn-glycero-3'-phosphocholine and method for obtaining 1',2'-di{2-[(2''E)-2''-butylidene-1'',3'',3''-trimethyl]cyclohexyl}acetyl-sn-glycero-3'-phosphocholine

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Publication number
PL418654A1
PL418654A1 PL418654A PL41865416A PL418654A1 PL 418654 A1 PL418654 A1 PL 418654A1 PL 418654 A PL418654 A PL 418654A PL 41865416 A PL41865416 A PL 41865416A PL 418654 A1 PL418654 A1 PL 418654A1
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PL
Poland
Prior art keywords
phosphocholine
butylidene
glycero
trimethyl
acetyl
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Application number
PL418654A
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Polish (pl)
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PL235017B1 (en
Inventor
Anna Gliszczyńska
Natalia Niezgoda
Witold Gładkowski
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
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Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL418654A priority Critical patent/PL235017B1/en
Publication of PL418654A1 publication Critical patent/PL418654A1/en
Publication of PL235017B1 publication Critical patent/PL235017B1/en

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Abstract

Zgłoszenie dotyczy 1,2-diizoprenoilo-sn-glicero-3-fosfocholiny, o wzorze 1 oraz sposobu jej otrzymywania na drodze estryfikacji kwasu 2-(2-butylideno-1,3,3-trimetylocykloheksylo)-octowego kompleksem sn-glicero-3-fosfocholiny i chlorku kadmu z udziałem czynnika sprzęgającego jakim jest N,N'-dicykloheksylokarbodiimid oraz w obecności 4-dimetyloaminopirydyny w środowisku bezwodnego chlorku metylenu. Zgłoszenie to może znaleźć zastosowanie w terapii chorób nowotworowych.The application relates to 1,2-diisoprenoyl-sn-glycerol-3-phosphocholine, of formula 1 and the method for its preparation by esterification of 2- (2-butylidene-1,3,3-trimethylcyclohexyl) acetic acid with sn-glycerol-3 complex phosphocholine and cadmium chloride with the participation of a coupling agent which is N, N'-dicyclohexylcarbodiimide and in the presence of 4-dimethylaminopyridine in anhydrous methylene chloride environment. This application may find application in the treatment of cancer.

PL418654A 2016-09-12 2016-09-12 1',2'-Di{2-[(2''E)-2''-butylidene-1'',3'',3''-trimethyl]cyclohexyl}acetyl-sn-glycero-3'-phosphocholine and method for obtaining 1',2'-di{2-[(2''E)-2''-butylidene-1'',3'',3''-trimethyl]cyclohexyl}acetyl-sn-glycero-3'-phosphocholine PL235017B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL418654A PL235017B1 (en) 2016-09-12 2016-09-12 1',2'-Di{2-[(2''E)-2''-butylidene-1'',3'',3''-trimethyl]cyclohexyl}acetyl-sn-glycero-3'-phosphocholine and method for obtaining 1',2'-di{2-[(2''E)-2''-butylidene-1'',3'',3''-trimethyl]cyclohexyl}acetyl-sn-glycero-3'-phosphocholine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL418654A PL235017B1 (en) 2016-09-12 2016-09-12 1',2'-Di{2-[(2''E)-2''-butylidene-1'',3'',3''-trimethyl]cyclohexyl}acetyl-sn-glycero-3'-phosphocholine and method for obtaining 1',2'-di{2-[(2''E)-2''-butylidene-1'',3'',3''-trimethyl]cyclohexyl}acetyl-sn-glycero-3'-phosphocholine

Publications (2)

Publication Number Publication Date
PL418654A1 true PL418654A1 (en) 2018-03-26
PL235017B1 PL235017B1 (en) 2020-05-18

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PL418654A PL235017B1 (en) 2016-09-12 2016-09-12 1',2'-Di{2-[(2''E)-2''-butylidene-1'',3'',3''-trimethyl]cyclohexyl}acetyl-sn-glycero-3'-phosphocholine and method for obtaining 1',2'-di{2-[(2''E)-2''-butylidene-1'',3'',3''-trimethyl]cyclohexyl}acetyl-sn-glycero-3'-phosphocholine

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PL (1) PL235017B1 (en)

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Publication number Publication date
PL235017B1 (en) 2020-05-18

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