PL423698A1 - Method for producing salicylic acid with increased purity - Google Patents

Method for producing salicylic acid with increased purity

Info

Publication number
PL423698A1
PL423698A1 PL423698A PL42369817A PL423698A1 PL 423698 A1 PL423698 A1 PL 423698A1 PL 423698 A PL423698 A PL 423698A PL 42369817 A PL42369817 A PL 42369817A PL 423698 A1 PL423698 A1 PL 423698A1
Authority
PL
Poland
Prior art keywords
salicylic acid
acid
salt
salicylate
neutralization reaction
Prior art date
Application number
PL423698A
Other languages
Polish (pl)
Inventor
Elżbieta DĄBROWSKA-MAŚ
Wojciech RAŚ
Bartłomiej ATAMAN
Kazimierz SMOLAK
Adam PSZENICZNY
Original Assignee
Valeant Pharmaceuticals Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valeant Pharmaceuticals Ireland filed Critical Valeant Pharmaceuticals Ireland
Priority to PL423698A priority Critical patent/PL423698A1/en
Publication of PL423698A1 publication Critical patent/PL423698A1/en

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób wytwarzania kwasu salicylowego o podwyższonej czystości polegający na reakcji zobojętnienia soli kwasu salicylowego charakteryzujący się tym, że sól kwasu salicylowego poddaje się reakcji zobojętnienia kwasem, w środowisku wodnym, po czym otrzymany kwas salicylowy rozpuszcza się w mieszaninie reakcyjnej, a po krystalizacji odsącza się go i przemywa. Korzystnie jest, gdy jako sól kwasu salicylowego stosuje się sól zawierającą metal. Korzystnie, gdy jest to salicylan sodu lub salicylan potasu lub salicylan magnezu. Korzystnie jest również, gdy jako sól kwasu salicylowego stosuje się sól zawierającą amoniak lub resztę aminową. Korzystnie, gdy jest to salicylan choliny. Korzystnie jest, gdy reakcję zobojętnienia prowadzi się przy użyciu kwasu nieorganicznego lub kwasu organicznego. Korzystnie, gdy jest to kwas solny lub kwas octowy. Rozpuszczanie otrzymanego kwasu salicylowego prowadzi się korzystnie w podwyższonej temperaturze, najlepiej w temperaturze wrzenia. Otrzymany kwas salicylowy korzystnie jest przemywać wodą.The subject of the application is a method of producing salicylic acid with increased purity consisting of a neutralization reaction of a salicylic acid salt characterized in that the salicylic acid salt is subjected to an acid neutralization reaction in an aqueous medium, after which the obtained salicylic acid dissolves in the reaction mixture and, after crystallization, is filtered off. wash and wash it. Preferably a metal-containing salt is used as the salicylic acid salt. Preferably it is sodium salicylate or potassium salicylate or magnesium salicylate. It is also preferred if a salt containing ammonia or an amino residue is used as the salicylic acid salt. Preferably it is choline salicylate. Preferably, the neutralization reaction is carried out using an inorganic acid or organic acid. Preferably it is hydrochloric acid or acetic acid. The dissolution of the salicylic acid obtained is preferably carried out at elevated temperature, preferably at boiling point. The resulting salicylic acid is preferably washed with water.

PL423698A 2017-12-04 2017-12-04 Method for producing salicylic acid with increased purity PL423698A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL423698A PL423698A1 (en) 2017-12-04 2017-12-04 Method for producing salicylic acid with increased purity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL423698A PL423698A1 (en) 2017-12-04 2017-12-04 Method for producing salicylic acid with increased purity

Publications (1)

Publication Number Publication Date
PL423698A1 true PL423698A1 (en) 2019-06-17

Family

ID=66809652

Family Applications (1)

Application Number Title Priority Date Filing Date
PL423698A PL423698A1 (en) 2017-12-04 2017-12-04 Method for producing salicylic acid with increased purity

Country Status (1)

Country Link
PL (1) PL423698A1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB986867A (en) * 1962-09-07 1965-03-24 Dow Chemical Co Method of preparing salicylic acid
US4137258A (en) * 1978-04-07 1979-01-30 The Dow Chemical Company Process for making pure salicylic acid
JPS62106047A (en) * 1985-10-29 1987-05-16 ロ−ヌ−プ−ラン・スペシアリテ・シミ−ク Separation and purification of salicylic acid
PL331398A1 (en) * 1999-02-11 2000-08-14 Inst Chemii Przemyslowej Im Pr Method of purifying crude salicylic acid
CN105418402A (en) * 2015-11-30 2016-03-23 山东新华制药股份有限公司 Production technology of salicylic acid

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB986867A (en) * 1962-09-07 1965-03-24 Dow Chemical Co Method of preparing salicylic acid
US4137258A (en) * 1978-04-07 1979-01-30 The Dow Chemical Company Process for making pure salicylic acid
JPS62106047A (en) * 1985-10-29 1987-05-16 ロ−ヌ−プ−ラン・スペシアリテ・シミ−ク Separation and purification of salicylic acid
PL331398A1 (en) * 1999-02-11 2000-08-14 Inst Chemii Przemyslowej Im Pr Method of purifying crude salicylic acid
CN105418402A (en) * 2015-11-30 2016-03-23 山东新华制药股份有限公司 Production technology of salicylic acid

Similar Documents

Publication Publication Date Title
CL2019002677A1 (en) Adhesive composition and method of preparing it.
SA517380894B1 (en) High density water well fluids
AR098110A1 (en) PROCESS FOR THE PREPARATION OF 3- (3-CHLORINE-1H-PIRAZOL-1-IL) PIRIDINE
BR112015011083A2 (en) process for producing aqueous mixtures of o-acyl isethionate-based surfactants and amino acid-based surfactants and composition
MY155044A (en) Conversion method
MY190283A (en) Method for producing crystals of diazabicyclooctane derivative and stable lyophilized preparation
UA113204C2 (en) SELECTIVE EXTRACTION OF POTASSIUM CHLORIDE FROM THE OUTSIDE SHENITA SOLUTION WITH THE USE OF TARTARIC ACID AS A SAFETY SOFT EXTRADENTS
BR112015027187A2 (en) manufacturing process of an aqueous antiperspirant composition and method of obtaining an antiperspirant benefit
PE20170212A1 (en) REACTIVE COMPOSITION BASED ON SODIUM BICARBONATE AND PROCEDURE FOR ITS PRODUCTION
PE20142107A1 (en) METHOD FOR RECOVERING GOLD ADSORBED ON ACTIVATED CARBON AND METHOD FOR PRODUCING GOLD BY SUCH METHOD
MY173792A (en) Process for obtaining methionine
MX379184B (en) SODIUM SALT OF URIC ACID TRANSPORTER INHIBITOR AND ITS CRYSTALLINE FORM.
ES2523346T3 (en) A process to prepare trichloroaminoplatinate salt and the products obtained therein
MX388902B (en) Method of enhanced conversion of taurine salts to alkyl taurate amides
EA200800068A1 (en) COMPOSITION AND IMPROVED METHOD FOR OBTAINING ALUMINUM HYDROXIDE
MX2019014863A (en) Method for cleaning rigid article.
SG11201900306WA (en) Method for producing fluorine-containing sulfonylamide compound
BR112019006206A2 (en) process for making a non-aqueous composition and use of surfactant crystals
CL2015000975A1 (en) Boussingaultite production process from liquid effluents containing magnesium sulphate
BR112017013246A2 (en) PROCESS TO PRODUCE 4-AZIDOSULPHONYLFTALIC ANIDYRID
PH12018501046A1 (en) Crystals of monovalent cation salt of 3-hydroxyisovaleric acid, and method for producing said crystals
TH176475A (en) Alkali crystals, N-acetyls, neuraminate anhydrates, and their manufacturing processes
AR113556A1 (en) ADHESIVE COMPOSITION AND PREPARATION METHOD OF THIS
JP2019031703A5 (en)
PL417603A1 (en) Method for producing crystalline form of hydrate thiocyanate [di(2-amino-5-guanidine-pentane)(thiocyanate)copper(II)] complex