PL424768A1 - Method for obtaining dibenzo[b,f]oxepine derivatives substituted in aromatic ring - Google Patents
Method for obtaining dibenzo[b,f]oxepine derivatives substituted in aromatic ringInfo
- Publication number
- PL424768A1 PL424768A1 PL424768A PL42476818A PL424768A1 PL 424768 A1 PL424768 A1 PL 424768A1 PL 424768 A PL424768 A PL 424768A PL 42476818 A PL42476818 A PL 42476818A PL 424768 A1 PL424768 A1 PL 424768A1
- Authority
- PL
- Poland
- Prior art keywords
- oxepine
- dibenzo
- methoxy
- formula
- obtaining
- Prior art date
Links
- QQQCGYCZORNOOS-UHFFFAOYSA-N benzo[b][1]benzoxepine Chemical group C1=CC2=CC=CC=C2OC2=CC=CC=C21 QQQCGYCZORNOOS-UHFFFAOYSA-N 0.000 title abstract 2
- 125000003118 aryl group Chemical group 0.000 title 1
- WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 abstract 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 4
- RTYBNNXASDEOBQ-UHFFFAOYSA-N 10-methoxy-2-nitrobenzo[b][1]benzoxepine Chemical class C1=CC2=CC=C([N+]([O-])=O)C=C2OC2=C1C=CC=C2OC RTYBNNXASDEOBQ-UHFFFAOYSA-N 0.000 abstract 3
- 229910015900 BF3 Inorganic materials 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- WTLUUYXFCHWUJK-UHFFFAOYSA-N 1-ethoxy-4-(4-ethoxyphenyl)benzene Chemical class C1=CC(OCC)=CC=C1C1=CC=C(OCC)C=C1 WTLUUYXFCHWUJK-UHFFFAOYSA-N 0.000 abstract 2
- NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical compound ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 abstract 2
- 229930040373 Paraformaldehyde Natural products 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000012074 organic phase Substances 0.000 abstract 1
- 229920002866 paraformaldehyde Polymers 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób otrzymywania nowych pochodnych dibenzo[b,f]oksepiny o wzorze 1 gdzie R oznacza podstawiony pierścień 6-metoksy-3-nitro dibenzo[b,f]oksepiny lub 4,4’-dietoksy-1,1’-bifenylu. Powyższy sposób polega na tym że 6-metoksy-3-nitrodibenzo[b,f]oksepinę o wzorze 2 lub 6-metoksy-3-nitrodibenzo[b,f]oksepinę i 4,4’-dietoksy-1,1’-bifenyl rozpuszcza się w chlorometanie i dodaje paraformaldehyd po czym do mieszaniny dodaje się trifluorek boru w eterze dietylowym [BF3•O(C2H5)2], w temperaturze 20-30°C, przy czym trifluorek boru stosuje się z dwukrotnym nadmiarem w stosunku do związku o wzorze 2, a pozostałe reagenty stosuje się w ilościach zbliżonych do stechiometrycznych, całość miesza się w temperaturze pokojowej, przelewa do metanolu a oddzieloną fazę organiczną suszy, zatęża i oczyszcza.The subject of the application is a method for obtaining new dibenzo[b,f]oxepine derivatives of formula 1 where R is a substituted 6-methoxy-3-nitro dibenzo[b,f]oxepine or 4,4'-diethoxy-1,1'-biphenyl ring . The above method consists in the addition of 6-methoxy-3-nitrodibenzo[b,f]oxepine of formula 2 or 6-methoxy-3-nitrodibenzo[b,f]oxepine and 4,4'-diethoxy-1,1'-biphenyl is dissolved in chloromethane and paraformaldehyde is added, then boron trifluoride in diethyl ether [BF3•O(C2H5)2] is added to the mixture at a temperature of 20-30°C, and boron trifluoride is used with a twice excess in relation to the compound with formula 2, and the remaining reagents are used in amounts close to stoichiometric, the whole thing is stirred at room temperature, poured into methanol, and the separated organic phase is dried, concentrated and purified.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL424768A PL238243B1 (en) | 2018-03-05 | 2018-03-05 | Method for obtaining dibenzo[b,f]oxepine derivatives substituted in aromatic ring |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL424768A PL238243B1 (en) | 2018-03-05 | 2018-03-05 | Method for obtaining dibenzo[b,f]oxepine derivatives substituted in aromatic ring |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL424768A1 true PL424768A1 (en) | 2019-09-09 |
| PL238243B1 PL238243B1 (en) | 2021-08-02 |
Family
ID=67844663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL424768A PL238243B1 (en) | 2018-03-05 | 2018-03-05 | Method for obtaining dibenzo[b,f]oxepine derivatives substituted in aromatic ring |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL238243B1 (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL403972A1 (en) * | 2013-05-20 | 2014-11-24 | Politechnika Warszawska | Process for preparing new derivatives of dibenzo[b,f]oxepin |
| PL408698A1 (en) * | 2014-06-30 | 2016-01-04 | Politechnika Warszawska | Method for obtaining methoxy derivatives of dibenz[b,f] oxepin |
-
2018
- 2018-03-05 PL PL424768A patent/PL238243B1/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL403972A1 (en) * | 2013-05-20 | 2014-11-24 | Politechnika Warszawska | Process for preparing new derivatives of dibenzo[b,f]oxepin |
| PL408698A1 (en) * | 2014-06-30 | 2016-01-04 | Politechnika Warszawska | Method for obtaining methoxy derivatives of dibenz[b,f] oxepin |
Also Published As
| Publication number | Publication date |
|---|---|
| PL238243B1 (en) | 2021-08-02 |
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