PL424773A1 - Enkapsulowana polisacharydem antracyklina do zastosowania w leczeniu nowotworów - Google Patents

Enkapsulowana polisacharydem antracyklina do zastosowania w leczeniu nowotworów

Info

Publication number
PL424773A1
PL424773A1 PL424773A PL42477318A PL424773A1 PL 424773 A1 PL424773 A1 PL 424773A1 PL 424773 A PL424773 A PL 424773A PL 42477318 A PL42477318 A PL 42477318A PL 424773 A1 PL424773 A1 PL 424773A1
Authority
PL
Poland
Prior art keywords
cancer
leukemia
anthracycline
treatment
thyroid
Prior art date
Application number
PL424773A
Other languages
English (en)
Inventor
Iga WASIAK
Tomasz CIACH
Aleksandra KULIKOWSKA-DARŁAK
Piotr Pietrzak
Agnieszka Sobiecka
Wioletta KOŚNIK
Joanna PIETRAS
Paweł ŻERO
Paweł Żuk
Justyna MAŁKOWSKA
Kinga ADAMSKA
Mikołaj CHROMIŃSKI
Adam Kiciak
Original Assignee
Nanovelos Spółka Akcyjna
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanovelos Spółka Akcyjna filed Critical Nanovelos Spółka Akcyjna
Priority to PL424773A priority Critical patent/PL424773A1/pl
Priority to ES19724635T priority patent/ES3052184T3/es
Priority to KR1020207027492A priority patent/KR102860522B1/ko
Priority to US16/978,476 priority patent/US20210052616A1/en
Priority to PL19724635.8T priority patent/PL3761955T3/pl
Priority to CN201980017745.XA priority patent/CN112165933B/zh
Priority to PCT/PL2019/050014 priority patent/WO2019172790A1/en
Priority to EP19724635.8A priority patent/EP3761955B1/en
Publication of PL424773A1 publication Critical patent/PL424773A1/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A61K47/6939—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being a polysaccharide, e.g. starch, chitosan, chitin, cellulose or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest enkapsulowana polisacharydem antracyklina do zastosowania w leczeniu nowotworu, charakteryzuje się tym, że antracyklina jest wybrana z epirubicyny, daunorubicyny, doksorubicyny, idarubicyny, i przy czym nowotwór jest wybrany z guzów litych wieku dziecięcego, guza Wilmsa, mięsaków, mięsaka tkanek miękkich, mięsaka Ewinga, chłoniaków, chłoniaka nieziarniczego, białaczki, ostrej białaczki, białaczki limfoblastycznej, białaczki mieloblastycznej, białaczki szpikowej, szpiczaka mnogiego, choroby Hodgkina, nowotworu piersi, raka piersi, nowotworu płuc, raka płuc, drobnokomórkowego raka płuca, nowotworu żołądka, raka żołądka, nowotworu pęcherza moczowego, brodawczakowego raka pęcherza moczowego z komórek nabłonka przejściowego, nowotworu tarczycy, raka tarczycy, raka brodawkowatego lub pęcherzykowego tarczycy, nowotworu trzustki, raka szyjki macicy, raka jajnika, raka endometrium, nowotworu nerki, kostniakomięsaka, neuroblastomy, nowotworu jelita grubego.
PL424773A 2018-03-06 2018-03-06 Enkapsulowana polisacharydem antracyklina do zastosowania w leczeniu nowotworów PL424773A1 (pl)

Priority Applications (8)

Application Number Priority Date Filing Date Title
PL424773A PL424773A1 (pl) 2018-03-06 2018-03-06 Enkapsulowana polisacharydem antracyklina do zastosowania w leczeniu nowotworów
ES19724635T ES3052184T3 (en) 2018-03-06 2019-03-05 Anthracycline encapsulated with polysaccharide for use in the treatment of tumours
KR1020207027492A KR102860522B1 (ko) 2018-03-06 2019-03-05 종양의 치료에 사용하기 위한 다당류로 캡슐화된 안트라사이클린
US16/978,476 US20210052616A1 (en) 2018-03-06 2019-03-05 Anthracycline encapsulated with a polysaccharide for use in the treatment of tumours
PL19724635.8T PL3761955T3 (pl) 2018-03-06 2019-03-05 Enkapsulowana polisacharydem antracyklina do zastosowania w leczeniu nowotworów
CN201980017745.XA CN112165933B (zh) 2018-03-06 2019-03-05 用于治疗肿瘤的多糖包裹蒽环霉素
PCT/PL2019/050014 WO2019172790A1 (en) 2018-03-06 2019-03-05 Anthracycline encapsulated with polysaccharide for use in the treatment of tumours
EP19724635.8A EP3761955B1 (en) 2018-03-06 2019-03-05 Anthracycline encapsulated with polysaccharide for use in the treatment of tumours

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL424773A PL424773A1 (pl) 2018-03-06 2018-03-06 Enkapsulowana polisacharydem antracyklina do zastosowania w leczeniu nowotworów

Publications (1)

Publication Number Publication Date
PL424773A1 true PL424773A1 (pl) 2019-09-09

Family

ID=66554462

Family Applications (2)

Application Number Title Priority Date Filing Date
PL424773A PL424773A1 (pl) 2018-03-06 2018-03-06 Enkapsulowana polisacharydem antracyklina do zastosowania w leczeniu nowotworów
PL19724635.8T PL3761955T3 (pl) 2018-03-06 2019-03-05 Enkapsulowana polisacharydem antracyklina do zastosowania w leczeniu nowotworów

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL19724635.8T PL3761955T3 (pl) 2018-03-06 2019-03-05 Enkapsulowana polisacharydem antracyklina do zastosowania w leczeniu nowotworów

Country Status (7)

Country Link
US (1) US20210052616A1 (pl)
EP (1) EP3761955B1 (pl)
KR (1) KR102860522B1 (pl)
CN (1) CN112165933B (pl)
ES (1) ES3052184T3 (pl)
PL (2) PL424773A1 (pl)
WO (1) WO2019172790A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102300362B1 (ko) * 2019-10-08 2021-09-08 고려대학교 산학협력단 간세포성 암종 특이적 항암 치료진단제

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006130455A2 (en) * 2005-05-27 2006-12-07 Royer Biomedical, Inc. Bioresorbable polymer matrices and methods of making and using the same
EP1917004A2 (de) * 2005-08-19 2008-05-07 Magforce Nanotechnologies AG Verfahren zur einschleusung von therapeutischen substanzen in zellen
PL221351B1 (pl) * 2012-03-14 2016-03-31 Politechnika Warszawska Sposób otrzymywania nanocząstek polisacharydowych

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2550261B2 (ja) * 1992-05-20 1996-11-06 株式会社ディ・ディ・エス研究所 酸化カルボキシメチルマンノグルカンードキソルビシン複合体
US20110104052A1 (en) * 2007-12-03 2011-05-05 The Johns Hopkins University Methods of synthesis and use of chemospheres
CN101653612A (zh) * 2009-07-23 2010-02-24 复旦大学 利用白蛋白-葡聚糖制备的阿霉素纳米制剂及其应用
EP2611424B1 (en) * 2010-08-31 2024-04-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Crosslinked polysaccharide beads and their biomedical uses
CN104523598B (zh) * 2014-12-16 2017-11-14 中国科学院长春应用化学研究所 葡聚糖/阿霉素键合药纳米粒及其制备方法
KR101842059B1 (ko) * 2016-02-05 2018-03-26 인하대학교 산학협력단 음이온성 작용기 및 아크릴레이트기가 도입된 광가교성 덱스트란 고분자 약물전달체 및 이의 제조방법
CN105727309B (zh) * 2016-03-31 2019-04-30 中国药科大学 双敏感两亲性多糖-阿霉素偶联物及其药学组合物的制备和应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006130455A2 (en) * 2005-05-27 2006-12-07 Royer Biomedical, Inc. Bioresorbable polymer matrices and methods of making and using the same
EP1917004A2 (de) * 2005-08-19 2008-05-07 Magforce Nanotechnologies AG Verfahren zur einschleusung von therapeutischen substanzen in zellen
PL221351B1 (pl) * 2012-03-14 2016-03-31 Politechnika Warszawska Sposób otrzymywania nanocząstek polisacharydowych

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SAVITA BISHT, AMARNATH MAITRA, DEXTRAN - DOXORUBICIN/CHITOSAN NANOPARTICLES FOR SOLID TUMOR THERAPY, 2009 *

Also Published As

Publication number Publication date
EP3761955A1 (en) 2021-01-13
KR102860522B1 (ko) 2025-09-16
WO2019172790A1 (en) 2019-09-12
KR20200128694A (ko) 2020-11-16
PL3761955T3 (pl) 2025-12-22
CN112165933A (zh) 2021-01-01
US20210052616A1 (en) 2021-02-25
EP3761955B1 (en) 2025-10-08
EP3761955C0 (en) 2025-10-08
CN112165933B (zh) 2024-04-16
ES3052184T3 (en) 2026-01-02

Similar Documents

Publication Publication Date Title
Kuoppala et al. Surgically staged high-risk endometrial cancer: randomized study of adjuvant radiotherapy alone vs. sequential chemo-radiotherapy
MX2021001957A (es) Compuestos de degradacion y metodos de uso del receptor de tropomiosina quinasa (trk).
PE20230373A1 (es) Conjugado anticuerpo-farmaco, metodo de preparacion del mismo y uso del mismo
MX2020008882A (es) Dosificación para tratamiento con anticuerpos antagonistas anti-tigit y anti-pd-l1.
CL2017001580A1 (es) Anticuerpo o fragmento de anticuerpo contra cd38 anticuerpo humanizado, conjugado del anticuerpo con un compuesto citotoxico composición farmacéutica con dichos anticuerpos uso de los anticuerpos para tratar cáncer o enfermedad autoinmune método para diagnosticar cáncer polinucleotido vector y célula huésped.
MX2020009111A (es) Metodos para tratar cancer con una combinacion de un agente basado en platino y un conjugado de anticuerpo anti-factor tisular-farmaco.
EA200100369A1 (ru) Химиотерапия рака с помощью ацетилдиналина в комбинации с гемцитабином, кэйпцитабином или цис-платиной
CR10143A (es) Antígenos de ácido des-n-acetil-siálico, anticuerpos para los mismos y métodos de uso en la terapia del cáncer
Lheureux et al. Expected benefits of topotecan combined with lapatinib in recurrent ovarian cancer according to biological profile: a phase 2 trial
MA32140B1 (fr) Utilisation d'un anticorps anti-cd20 de type ii à cytotoxicité cellulaire accrue dépendant des anticorps (adcc) combiné au cyclophosphamide, à la vincristine et à la doxorubicine pour traiter les lymphomes non hodgkiniens
JP2004534741A5 (pl)
EP4219556A3 (en) Human monoclonal antibodies specific for flt3 and uses thereof
CR20240415A (es) MOLÉCULAS DE UNIÓN CONTRA FRa
EA202092136A1 (ru) Способы лечения рака с помощью комбинации антитела к pd-1 и конъюгата антитела к тканевому фактору и лекарственного средства
CA3156022A1 (en) METHODS OF TREATING CANCER USING A COMBINATION OF A PLATINUM AGENT AND AN ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATE
PL424773A1 (pl) Enkapsulowana polisacharydem antracyklina do zastosowania w leczeniu nowotworów
DOP2009000208A (es) Métodos de tratamiento del cáncer mediante administración de combinaciones de il-18 humana
MX2022005222A (es) Metodos para tratar el cancer con una combinacion de un anticuerpo anti muerte programada 1 (pd-1) y un conjugado de anticuerpo anti factor tisular-farmaco.
Audino et al. Rhabdomyosarcoma of the breast in adolescent and young adult (AYA) women
Iqbal et al. Neoadjuvant chemotherapy in locally advanced breast cancer
Lavoie et al. 18F FDG positron-emission tomography findings of gliomatosis peritonei: A case report and review of the literature
Arowolo et al. The impact of neoadjuvant chemotherapy on patients with locally advanced breast cancer in a Nigerian semiurban teaching hospital: a single-center descriptive study
Jillella et al. P-glycoprotein expression and multidrug resistance in cutaneous T-cell lymphoma
Sallman et al. Abstract CT068: Phase Ib/II combination study of APR-246 and azacitidine (AZA) in patients with TP53 mutant myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML)
Konofaos et al. Challenges in the surgical treatment of retroperitoneal sarcomas