PL426820A1 - Method of hydrophilization of polylactide spongy bone substitute - Google Patents
Method of hydrophilization of polylactide spongy bone substituteInfo
- Publication number
- PL426820A1 PL426820A1 PL426820A PL42682018A PL426820A1 PL 426820 A1 PL426820 A1 PL 426820A1 PL 426820 A PL426820 A PL 426820A PL 42682018 A PL42682018 A PL 42682018A PL 426820 A1 PL426820 A1 PL 426820A1
- Authority
- PL
- Poland
- Prior art keywords
- solution
- concentration
- ions
- implant
- hydrophilization
- Prior art date
Links
- 229920000747 poly(lactic acid) Polymers 0.000 title abstract 2
- 239000000316 bone substitute Substances 0.000 title 1
- 239000000243 solution Substances 0.000 abstract 6
- 239000007943 implant Substances 0.000 abstract 3
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 abstract 2
- 239000007995 HEPES buffer Substances 0.000 abstract 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
- 239000011591 potassium Substances 0.000 abstract 2
- 229910052700 potassium Inorganic materials 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910001622 calcium bromide Inorganic materials 0.000 abstract 1
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 1
- 239000001110 calcium chloride Substances 0.000 abstract 1
- 229910001640 calcium iodide Inorganic materials 0.000 abstract 1
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Inorganic materials [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 abstract 1
Landscapes
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób hydrofilizacji dynamicznego polilaktydowego substytutu kości gąbczastej, który polega na tym, że sporządza się roztwór bezwodnej soli wapnia, wybranej spośród chlorku, bromku, jodku lub azotanu wapnia, o stężeniu jonów wapnia co najmniej 2,5 mM oraz roztwór bezwodnego wodorowęglanu sodu lub potasu i uwodnionego ortofosforanu (V) sodu o stężeniu jonów wodorowęglanowych co najmniej 18 mM oraz jonów ortofosforanowych (V) co najmniej 2,5 mM, przy czym oba rozwory sporządza się w wodnym buforze HEPES/sól sodowa lub potasowa HEPES o stężeniu 0,1 - 1M oraz pH w zakresie 6 - 8. Każdy z roztworów miesza się oddzielnie w temperaturze 30 - 45°C przez 10 - 30 min., a następnie oba roztwory łączy się w stosunku molowym Ca do P jak 1:1 i miesza w temperaturze 30 - 45°C przez 20 - 40 min., po czym połączonym roztworem zalewa się implant umieszczony w formie cylindrycznej z zakręcanym wieczkiem i stożkowym dnem, przy czym stosuje się implant uprzednio nasączony alkoholem C1-C3. Formę wytrząsa się w temperaturze 30 - 45°C, przy obrotach 100 - 200 rpm, przez 1 - 5 dni, a następnie implant suszy się próżniowo w temperaturze 30 - 45°C przez 8 - 24 h.The subject of the application is a method of hydrophilization of a dynamic polylactide substitute of spongiform bone, which consists in preparing a solution of anhydrous calcium salt, selected from among calcium chloride, bromide, iodide or nitrate, with a concentration of calcium ions at least 2.5 mM, and a solution of anhydrous sodium bicarbonate or potassium and hydrated sodium orthophosphate with a concentration of bicarbonate ions at least 18 mM and orthophosphate (V) ions at least 2.5 mM, both solutions are prepared in aqueous HEPES buffer / sodium or potassium HEPES at a concentration of 0, 1 - 1M and a pH in the range 6 - 8. Each solution is mixed separately at 30 - 45 ° C for 10 - 30 min., Then both solutions are combined in a Ca to P molar ratio of 1: 1 and mixed at temperature 30 - 45 ° C for 20 - 40 minutes, after which the combined solution is poured over the implant placed in a cylindrical form with a screw cap and a conical bottom, using the implant previously soaked in alcohol C 1 -C 3 ol. The mold is shaken at 30-45 ° C, 100-200 rpm for 1-5 days, then the implant is vacuum dried at 30-45 ° C for 8-24 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL426820A PL236858B1 (en) | 2018-08-27 | 2018-08-27 | Method of hydrophilization of polylactide spongy bone substitute |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL426820A PL236858B1 (en) | 2018-08-27 | 2018-08-27 | Method of hydrophilization of polylactide spongy bone substitute |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL426820A1 true PL426820A1 (en) | 2020-03-09 |
| PL236858B1 PL236858B1 (en) | 2021-02-22 |
Family
ID=69709469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL426820A PL236858B1 (en) | 2018-08-27 | 2018-08-27 | Method of hydrophilization of polylactide spongy bone substitute |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL236858B1 (en) |
-
2018
- 2018-08-27 PL PL426820A patent/PL236858B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL236858B1 (en) | 2021-02-22 |
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