PL427554A1 - Biologiczna membrana barierowa - Google Patents

Biologiczna membrana barierowa

Info

Publication number
PL427554A1
PL427554A1 PL427554A PL42755418A PL427554A1 PL 427554 A1 PL427554 A1 PL 427554A1 PL 427554 A PL427554 A PL 427554A PL 42755418 A PL42755418 A PL 42755418A PL 427554 A1 PL427554 A1 PL 427554A1
Authority
PL
Poland
Prior art keywords
membrane
fibers
hydroxyapatite
fibrous structure
prepared
Prior art date
Application number
PL427554A
Other languages
English (en)
Other versions
PL240082B1 (pl
Inventor
Julia ROGOWSKA-TYLMAN
Giuseppino Fortunato
Bartosz WOŹNIAK
Agnieszka CHODARA
Witold ŁOJKOWSKI
Original Assignee
Instytut Wysokich Ciśnień Polskiej Akademii Nauk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instytut Wysokich Ciśnień Polskiej Akademii Nauk filed Critical Instytut Wysokich Ciśnień Polskiej Akademii Nauk
Priority to PL427554A priority Critical patent/PL240082B1/pl
Priority to PCT/PL2019/050057 priority patent/WO2020085927A1/en
Priority to EP19828347.5A priority patent/EP3870133B1/en
Publication of PL427554A1 publication Critical patent/PL427554A1/pl
Publication of PL240082B1 publication Critical patent/PL240082B1/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/50—Preparations specially adapted for dental root treatment
    • A61K6/58—Preparations specially adapted for dental root treatment specially adapted for dental implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses

Landscapes

  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Przedmiotem zgłoszenia jest membrana, która ma postać cienkiej, porowatej i elastycznej struktury włóknistej ze spontanicznie rozmieszczonych włókien polimerowych (9) o grubości od 0,5 do 4 µm. Powierzchnia właściwa materiału membrany wynosi od 5 m2/g do 20 m2/g. Włókna (9) membrany pokryte są nanocząstkami hydroksyapatytu, o rozmiarze nie większym niż 50 nm i stosunku molowym wapnia do fosforu (Ca/P) z zakresu od 1,56 do 1,66, przy czym zawartość hydroksyapatytu w membranie wynosi od 10 do 25% wagowo. Materiał włókien (9) stanowi mieszanina poli-DL-laktydu (PDLLA) i poliaktydu-glikolidu (PLGA). Pokrycie włókien (9) membrany hydroksyapatytem ma postać osnowy tych włókien (9) o grubości od 10 do 300 nm, przy czym stopień pokrycia włókien (9) cząstkami hydroksyapatytu wynosi nie mniej niż 40%. Porowatość membrany wynosi od 50 do 95%, rozmiar jej porów wynosi 5 do 30 µm, a jej nasiąkliwość wynosi od 300 do 600%. Zgłoszenie obejmuje też sposób wytwarzania takiej membrany, który zawiera etap wytwarzania opisanej wyżej struktury włóknistej metodą elektroprzędzenia z roztworu polimeru oraz etap pokrywania zanurzeniowego warstwą hydroksyapatytu włókien polimerowych (9) wytworzonej struktury. W pierwszym etapie strukturę włóknistą wytwarza się z roztworu sporządzonego z mieszaniny poli-DL-laktydu (PDLLA) i poliaktydu-glikolidu (PLGA) oraz rozpuszczalnika lotnego. W drugim etapie wytwarza się zawiesinę wodną (1) o temperaturze nie większej niż 30°C, w której fazą rozpraszaną są cząstki hydroksyapatytu o średnim rozmiarze ziaren nie większym niż 50 nm i ich udziale wagowym w całości zawiesiny nie większym niż 0,5%. Po zanurzeniu struktury włóknistej w sporządzonej zawiesinie, w sąsiedztwie włókien (9) tej struktury, wytwarza się falę ultradźwiękową o intensywności mocy z zakresu od 3 do 15 W/cm2 i trwającą przez co najmniej cztery minuty.
PL427554A 2018-10-26 2018-10-26 Biologiczna membrana separacyjna PL240082B1 (pl)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PL427554A PL240082B1 (pl) 2018-10-26 2018-10-26 Biologiczna membrana separacyjna
PCT/PL2019/050057 WO2020085927A1 (en) 2018-10-26 2019-10-26 Biological barrier membrane
EP19828347.5A EP3870133B1 (en) 2018-10-26 2019-10-26 Biological barrier membrane

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL427554A PL240082B1 (pl) 2018-10-26 2018-10-26 Biologiczna membrana separacyjna

Publications (2)

Publication Number Publication Date
PL427554A1 true PL427554A1 (pl) 2020-05-04
PL240082B1 PL240082B1 (pl) 2022-02-14

Family

ID=69024574

Family Applications (1)

Application Number Title Priority Date Filing Date
PL427554A PL240082B1 (pl) 2018-10-26 2018-10-26 Biologiczna membrana separacyjna

Country Status (3)

Country Link
EP (1) EP3870133B1 (pl)
PL (1) PL240082B1 (pl)
WO (1) WO2020085927A1 (pl)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114606499A (zh) * 2022-04-07 2022-06-10 燕山大学 一种表面具有微孔结构的金属及其制备方法与应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113088056B (zh) * 2021-05-20 2022-05-31 中国科学院长春应用化学研究所 一种含有纤维状孔的聚乳酸多孔材料及其制备方法
CN114796622B (zh) * 2022-04-24 2023-04-11 深圳光华伟业股份有限公司 一种含聚乳酸生物医用植入膜的制备方法
CN115678233B (zh) * 2023-01-03 2023-03-31 北京德益达美医疗科技有限公司 一种增韧型可吸收复合材料及其制备方法
CN117431425A (zh) * 2023-10-26 2024-01-23 中铝洛阳铜加工有限公司 一种深远海养殖用铜合金材料及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090114063A (ko) * 2008-04-29 2009-11-03 단국대학교 산학협력단 표면 개질된 나노 섬유막 및 이의 제조방법
PL226891B1 (pl) * 2015-05-05 2017-09-29 Inst Wysokich Ciśnień Polskiej Akademii Nauk Sposób wytwarzania implantu kostnego iimplant kostny

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114606499A (zh) * 2022-04-07 2022-06-10 燕山大学 一种表面具有微孔结构的金属及其制备方法与应用

Also Published As

Publication number Publication date
EP3870133A1 (en) 2021-09-01
EP3870133B1 (en) 2025-06-18
PL240082B1 (pl) 2022-02-14
WO2020085927A1 (en) 2020-04-30

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