PL428033A1 - 7-O-Biotinylflavone and method of preparing 7-O-biotinylflavone - Google Patents
7-O-Biotinylflavone and method of preparing 7-O-biotinylflavoneInfo
- Publication number
- PL428033A1 PL428033A1 PL428033A PL42803318A PL428033A1 PL 428033 A1 PL428033 A1 PL 428033A1 PL 428033 A PL428033 A PL 428033A PL 42803318 A PL42803318 A PL 42803318A PL 428033 A1 PL428033 A1 PL 428033A1
- Authority
- PL
- Poland
- Prior art keywords
- biotinylflavone
- preparing
- flavone
- dimethylaminopyridine
- dimethylaminopropyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 abstract 2
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 abstract 2
- MQGPSCMMNJKMHQ-UHFFFAOYSA-N 7-hydroxyflavone Chemical compound C=1C(O)=CC=C(C(C=2)=O)C=1OC=2C1=CC=CC=C1 MQGPSCMMNJKMHQ-UHFFFAOYSA-N 0.000 abstract 2
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 abstract 1
- 229960002685 biotin Drugs 0.000 abstract 1
- 235000020958 biotin Nutrition 0.000 abstract 1
- 239000011616 biotin Substances 0.000 abstract 1
- 239000007822 coupling agent Substances 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 229930003944 flavone Natural products 0.000 abstract 1
- 150000002212 flavone derivatives Chemical class 0.000 abstract 1
- 235000011949 flavones Nutrition 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Wynalazek dotyczy nowego flawonu z cząsteczką biotyny w pozycji C-7, jakim jest 7-O-biotynyloflawon o wzorze 1 oraz sposobu jego otrzymywania na drodze estryfikacji z 7-hydroksyflawonu z udziałem czynnika sprzęgającego jakim jest chlorowodorek 1-etylo-3-(3dimetyloaminopropylo)karbodiimidu oraz w obecności 4-dimetyloaminopirydyny w środowisku N,N-dimetyloformamidu. Wynalazek ten może znaleźć zastosowanie w przemyśle farmaceutycznym, spożywczym lub chemicznym.The invention relates to a new flavone with a biotin molecule at the C-7 position, which is 7-O-biotinylflavone of the formula 1, and the method of its preparation by esterification from 7-hydroxy flavone with the coupling agent which is 1-ethyl-3- (3-dimethylaminopropyl) hydrochloride carbodiimide and in the presence of 4-dimethylaminopyridine in the medium of N, N-dimethylformamide. The invention may find application in the pharmaceutical, food or chemical industries.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL428033A PL236266B1 (en) | 2018-12-03 | 2018-12-03 | 7-O-Biotinylflavone and the method of obtaining 7-O-biotinylflavone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL428033A PL236266B1 (en) | 2018-12-03 | 2018-12-03 | 7-O-Biotinylflavone and the method of obtaining 7-O-biotinylflavone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL428033A1 true PL428033A1 (en) | 2020-06-15 |
| PL236266B1 PL236266B1 (en) | 2020-12-28 |
Family
ID=71086894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL428033A PL236266B1 (en) | 2018-12-03 | 2018-12-03 | 7-O-Biotinylflavone and the method of obtaining 7-O-biotinylflavone |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL236266B1 (en) |
-
2018
- 2018-12-03 PL PL428033A patent/PL236266B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL236266B1 (en) | 2020-12-28 |
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