PL431196A1 - Method of producing 12β-hydroxyoxandrolone - Google Patents

Method of producing 12β-hydroxyoxandrolone

Info

Publication number
PL431196A1
PL431196A1 PL431196A PL43119619A PL431196A1 PL 431196 A1 PL431196 A1 PL 431196A1 PL 431196 A PL431196 A PL 431196A PL 43119619 A PL43119619 A PL 43119619A PL 431196 A1 PL431196 A1 PL 431196A1
Authority
PL
Poland
Prior art keywords
hydroxyoxandrolone
producing
formula
oxandrolone
substrate
Prior art date
Application number
PL431196A
Other languages
Polish (pl)
Other versions
PL238973B1 (en
Inventor
Alina Świzdor
Paulina Łyczko
Anna Panek
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL431196A priority Critical patent/PL238973B1/en
Publication of PL431196A1 publication Critical patent/PL431196A1/en
Publication of PL238973B1 publication Critical patent/PL238973B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Wynalazek dotyczy sposobu wytwarzania 12ß-hydroksyoksandrolonu, o wzorze 2, na drodze mikrobiologicznej hydroksylacji, w której jako substrat stosuje się oksandrolon, o wzorze 1, przy użyciu systemu enzymatycznego grzyba strzępkowego Fusarium culmorum AM282.The invention relates to a process for the preparation of 12β-hydroxyoxandrolone of formula 2 by microbial hydroxylation using oxandrolone of formula 1 as substrate using the Fusarium culmorum AM282 filamentous fungus enzyme system.

PL431196A 2019-09-18 2019-09-18 Method of producing 12β-hydroxyoxandrolone PL238973B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL431196A PL238973B1 (en) 2019-09-18 2019-09-18 Method of producing 12β-hydroxyoxandrolone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL431196A PL238973B1 (en) 2019-09-18 2019-09-18 Method of producing 12β-hydroxyoxandrolone

Publications (2)

Publication Number Publication Date
PL431196A1 true PL431196A1 (en) 2021-03-22
PL238973B1 PL238973B1 (en) 2021-10-25

Family

ID=75107950

Family Applications (1)

Application Number Title Priority Date Filing Date
PL431196A PL238973B1 (en) 2019-09-18 2019-09-18 Method of producing 12β-hydroxyoxandrolone

Country Status (1)

Country Link
PL (1) PL238973B1 (en)

Also Published As

Publication number Publication date
PL238973B1 (en) 2021-10-25

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