PL431767A1 - Preparation of 2-pentylbenzoic acid - Google Patents
Preparation of 2-pentylbenzoic acidInfo
- Publication number
- PL431767A1 PL431767A1 PL431767A PL43176719A PL431767A1 PL 431767 A1 PL431767 A1 PL 431767A1 PL 431767 A PL431767 A PL 431767A PL 43176719 A PL43176719 A PL 43176719A PL 431767 A1 PL431767 A1 PL 431767A1
- Authority
- PL
- Poland
- Prior art keywords
- water
- pentylbenzoic acid
- preparation
- until
- substrate
- Prior art date
Links
- JCYPDKSGYHGCCY-UHFFFAOYSA-N 2-pentylbenzoic acid Chemical compound CCCCCC1=CC=CC=C1C(O)=O JCYPDKSGYHGCCY-UHFFFAOYSA-N 0.000 title abstract 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- WMBOCUXXNSOQHM-UHFFFAOYSA-N 3-butylidene-2-benzofuran-1-one Chemical compound C1=CC=C2C(=CCCC)OC(=O)C2=C1 WMBOCUXXNSOQHM-UHFFFAOYSA-N 0.000 abstract 1
- 241000122824 Aspergillus ochraceus Species 0.000 abstract 1
- 230000005526 G1 to G0 transition Effects 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 1
- 239000001569 carbon dioxide Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 239000003480 eluent Substances 0.000 abstract 1
- 238000009630 liquid culture Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000000741 silica gel Substances 0.000 abstract 1
- 229910002027 silica gel Inorganic materials 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób wytwarzania kwasu 2-pentylobenzoesowego charakteryzującego się tym, że do płynnej hodowli Aspergillus ochraceus AM456, w fazie stacjonarnej, dodaje się substrat 3-n-butylidenoftalid o wzorze 1, rozpuszczony w rozpuszczalniku mieszającym się z wodą, przy czym proces prowadzony jest do całkowitego przereagowania substratu, następnie dodaje się wodorowęglan sodu do momentu aż przestanie wydzielać się dwutlenek węgla, kolejno produkt oczyszcza się krystalizując z wody i/lub oczyszczając na żelu krzemionkowym stosując eluent o składzie dichlorometan i metanol.The subject of the application is a process for the production of 2-pentylbenzoic acid, characterized in that the substrate 3-n-butylidene phthalide of the formula 1, dissolved in a water-miscible solvent, is added to the liquid culture of Aspergillus ochraceus AM456 in the stationary phase. until the substrate reacts completely, then sodium bicarbonate is added until no more carbon dioxide is evolved, then the product is purified by crystallization from water and / or by purification on silica gel using an eluent composed of dichloromethane and methanol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL431767A PL431767A1 (en) | 2019-11-12 | 2019-11-12 | Preparation of 2-pentylbenzoic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL431767A PL431767A1 (en) | 2019-11-12 | 2019-11-12 | Preparation of 2-pentylbenzoic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL431767A1 true PL431767A1 (en) | 2021-05-17 |
Family
ID=75882821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL431767A PL431767A1 (en) | 2019-11-12 | 2019-11-12 | Preparation of 2-pentylbenzoic acid |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL431767A1 (en) |
-
2019
- 2019-11-12 PL PL431767A patent/PL431767A1/en unknown
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