PL432200A1 - Dooponowe podanie limfocytów T regulatorowych jako leku w leczeniu stwardnienia rozsianego - Google Patents

Dooponowe podanie limfocytów T regulatorowych jako leku w leczeniu stwardnienia rozsianego

Info

Publication number
PL432200A1
PL432200A1 PL432200A PL43220019A PL432200A1 PL 432200 A1 PL432200 A1 PL 432200A1 PL 432200 A PL432200 A PL 432200A PL 43220019 A PL43220019 A PL 43220019A PL 432200 A1 PL432200 A1 PL 432200A1
Authority
PL
Poland
Prior art keywords
multiple sclerosis
regulatory
cells
intrathecal administration
sclerosis drug
Prior art date
Application number
PL432200A
Other languages
English (en)
Other versions
PL241050B1 (pl
Inventor
Piotr TRZONKOWSKI
Kamil CHWOJNICKI
Original Assignee
Gdański Uniwersytet Medyczny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gdański Uniwersytet Medyczny filed Critical Gdański Uniwersytet Medyczny
Priority to PL432200A priority Critical patent/PL241050B1/pl
Priority to CN202080086174.8A priority patent/CN114786688B/zh
Priority to KR1020227024028A priority patent/KR20220114047A/ko
Priority to EP20841790.7A priority patent/EP4058034A1/en
Priority to US17/755,016 priority patent/US20220387490A1/en
Priority to PCT/PL2020/000094 priority patent/WO2021118374A1/en
Priority to JP2022534320A priority patent/JP7624683B2/ja
Publication of PL432200A1 publication Critical patent/PL432200A1/pl
Publication of PL241050B1 publication Critical patent/PL241050B1/pl
Priority to US19/407,506 priority patent/US20260083664A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/505—CD4; CD8
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Przedmiotem wynalazku jest produkt limfocytów Tregs CD3+CD4+CD25+CD127 - do zastosowania jako lek do leczenia stwardnienia rozsianego.
PL432200A 2019-12-12 2019-12-12 Zastosowanie limfocytów T regulatorowych jako leku w leczeniu stwardnienia rozsianego PL241050B1 (pl)

Priority Applications (8)

Application Number Priority Date Filing Date Title
PL432200A PL241050B1 (pl) 2019-12-12 2019-12-12 Zastosowanie limfocytów T regulatorowych jako leku w leczeniu stwardnienia rozsianego
CN202080086174.8A CN114786688B (zh) 2019-12-12 2020-12-11 治疗多发性硬化症中鞘内施用调节性t细胞
KR1020227024028A KR20220114047A (ko) 2019-12-12 2020-12-11 다발성 경화증의 치료에서 t 조절 세포의 수막강내 투여
EP20841790.7A EP4058034A1 (en) 2019-12-12 2020-12-11 Intrathecal administration of t regulatory cells in the treatment of multiple sclerosis
US17/755,016 US20220387490A1 (en) 2019-12-12 2020-12-11 Intrathecal administration of t regulatory cells in the treatment of multiple sclerosis
PCT/PL2020/000094 WO2021118374A1 (en) 2019-12-12 2020-12-11 Intrathecal administration of t regulatory cells in the treatment of multiple sclerosis
JP2022534320A JP7624683B2 (ja) 2019-12-12 2020-12-11 多発性硬化症の治療における制御性ｔ細胞の髄腔内投与
US19/407,506 US20260083664A1 (en) 2019-12-12 2025-12-03 Intrathecal administration of t regulatory cells in the treatment of multiple sclerosis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL432200A PL241050B1 (pl) 2019-12-12 2019-12-12 Zastosowanie limfocytów T regulatorowych jako leku w leczeniu stwardnienia rozsianego

Publications (2)

Publication Number Publication Date
PL432200A1 true PL432200A1 (pl) 2021-06-14
PL241050B1 PL241050B1 (pl) 2022-07-25

Family

ID=74183501

Family Applications (1)

Application Number Title Priority Date Filing Date
PL432200A PL241050B1 (pl) 2019-12-12 2019-12-12 Zastosowanie limfocytów T regulatorowych jako leku w leczeniu stwardnienia rozsianego

Country Status (7)

Country Link
US (2) US20220387490A1 (pl)
EP (1) EP4058034A1 (pl)
JP (1) JP7624683B2 (pl)
KR (1) KR20220114047A (pl)
CN (1) CN114786688B (pl)
PL (1) PL241050B1 (pl)
WO (1) WO2021118374A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102596140B1 (ko) * 2021-09-13 2023-11-01 주식회사 브이티바이오 조절 t 세포를 유효성분으로 포함하는 퇴행성 뇌질환 예방 또는 치료용 약학적 조성물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005204338A1 (en) * 2005-03-02 2006-09-21 Sydney West Area Health Service Treatment for multiple sclerosis
EP2364163B1 (en) * 2008-07-18 2016-03-16 SentoClone International AB Composition comprising in vitro expanded t-lymphocytes and vessel formation inhibitors suitable in the treatment of cancer
CN102755633B (zh) * 2011-04-28 2014-08-27 北京大学 人重组蛋白pdcd5在治疗自身免疫病中的应用
PL218400B1 (pl) * 2012-06-06 2014-11-28 Gdański Univ Medyczny Szczepionka do leczenia cukrzycy typu 1 u dzieci, zastosowanie sortera komórek oraz sposób namnażania komórek Treg in vitro do wytwarzania szczepionki do leczenia cukrzycy typu 1
RU2523058C2 (ru) * 2012-06-29 2014-07-20 Общество с ограниченной ответственностью "Регенекс" Способ терапии ремиттирующего рассеянного склероза
US20170038394A1 (en) * 2014-04-16 2017-02-09 Genovie Ab Method for the identification of cd4+ regulatory t-cells for use in the treatment of inflammatory and autoimmune diseases
US20170199186A1 (en) * 2014-06-06 2017-07-13 Singapore Health Services Pte Ltd. Methods of using cells associated with autoimmune disease
KR102769850B1 (ko) * 2015-07-03 2025-02-20 인스티튜트 내셔날 드 라 싼테 에 드 라 리셰르셰 메디칼르 조절 t 세포를 수득하는 방법 및 이의 용도
PL236046B1 (pl) * 2015-12-17 2020-11-30 Gdanski Univ Medyczny Sposób namnażania in vitro limfocytów T regulatorowych CD4+ FoxP3+
WO2018024895A1 (en) * 2016-08-05 2018-02-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Immunotherapeutic uses of ex vivo generated foxp3+ regulatory t cells
US12227756B2 (en) * 2018-04-18 2025-02-18 Ucl Business Ltd Engineered regulatory T cell

Also Published As

Publication number Publication date
CN114786688B (zh) 2024-10-01
EP4058034A1 (en) 2022-09-21
JP2023505785A (ja) 2023-02-13
PL241050B1 (pl) 2022-07-25
CN114786688A (zh) 2022-07-22
KR20220114047A (ko) 2022-08-17
US20220387490A1 (en) 2022-12-08
WO2021118374A1 (en) 2021-06-17
US20260083664A1 (en) 2026-03-26
JP7624683B2 (ja) 2025-01-31

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