PL435416A1 - Sposób wytwarzania soli 1-(N-acyloamino)alkilotriarylofosfoniowych - Google Patents
Sposób wytwarzania soli 1-(N-acyloamino)alkilotriarylofosfoniowychInfo
- Publication number
- PL435416A1 PL435416A1 PL435416A PL43541620A PL435416A1 PL 435416 A1 PL435416 A1 PL 435416A1 PL 435416 A PL435416 A PL 435416A PL 43541620 A PL43541620 A PL 43541620A PL 435416 A1 PL435416 A1 PL 435416A1
- Authority
- PL
- Poland
- Prior art keywords
- general formula
- et2o
- alkyltriarylphosphonium
- acylamino
- salts
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 8
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
- 150000003951 lactams Chemical class 0.000 abstract 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Abstract
Przedmiotem zgłoszenia jest sposób wytwarzania soli 1-(N-acyloamino)alkilotriarylofosfoniowych o wzorze ogólnym 1, w którym R1 oznacza Me, Ph, t-Bu, BnO; R2 oznacza H, Me, Et, Ph, i-Pr, 2-tienyl; R3 oznacza H, Me lub R1 i R3 razem oznaczają (CH2)3; Ar oznacza Ph, 3-C6H4Cl, 4-C6H4OMe; X oznacza BF4, Br, który polega na tym, że aldehydy o wzorze ogólnym 2, w którym R2 oznacza H, Me, Et, Ph, i-Pr, 2-tienyl; amidy, karbaminiany, lub laktamy o wzorze ogólnym 3, w którym R1 oznacza Me, Ph, t-Bu, BnO; R3 oznacza H, Me lub R1 i R3 razem oznaczają (CH2)3 oraz sole triarylofosfoniowe o wzorze ogólnym 4, w którym Ar oznacza Ph, 3-C6H4Cl, 4-C6H4OMe; X oznacza BF4, Br miesza się w stosunku molowym 1:1:1, aldehyd o wzorze ogólnym 2: amid/karbaminian/laktam o wzorze ogólnym 3: sól triarylofosfoniowa o wzorze ogólnym 4 lub miesza z nadmiarem aldehydu 1,2:1:0,9 w rozpuszczalnikach organicznych takich jak CH3CN, CHCl3, CH2Cl2, THF lub bez użycia rozpuszczalnika, przy czym proces prowadzi się w temperaturze 25° - 135°C, korzystnie w temperaturze 50°C, w czasie 1 – 48h, po czym surową sól 1-(N-acyloamino)alkilotriarylofosfoniową strąca się za pomocą Et2O lub heksanu, następnie korzystnie rekrystalizuje z CH3CN lub układów CHCl3/Et2O, CH3CN/Et2O, CH2Cl2/Et2O.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL435416A PL243696B1 (pl) | 2020-09-22 | 2020-09-22 | Sposób wytwarzania soli 1-(N-acyloamino)alkilotriarylofosfoniowych |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL435416A PL243696B1 (pl) | 2020-09-22 | 2020-09-22 | Sposób wytwarzania soli 1-(N-acyloamino)alkilotriarylofosfoniowych |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL435416A1 true PL435416A1 (pl) | 2022-03-28 |
| PL243696B1 PL243696B1 (pl) | 2023-10-02 |
Family
ID=80855563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL435416A PL243696B1 (pl) | 2020-09-22 | 2020-09-22 | Sposób wytwarzania soli 1-(N-acyloamino)alkilotriarylofosfoniowych |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL243696B1 (pl) |
-
2020
- 2020-09-22 PL PL435416A patent/PL243696B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL243696B1 (pl) | 2023-10-02 |
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