PL437234A1 - Dwufazowy biomateriał na bazie kurdlanu oraz hydroksyapatytu (HAp) do regeneracji ubytków cbrzęstno-kostnych oraz sposób jego otrzymywania - Google Patents

Dwufazowy biomateriał na bazie kurdlanu oraz hydroksyapatytu (HAp) do regeneracji ubytków cbrzęstno-kostnych oraz sposób jego otrzymywania

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Publication number
PL437234A1
PL437234A1 PL437234A PL43723421A PL437234A1 PL 437234 A1 PL437234 A1 PL 437234A1 PL 437234 A PL437234 A PL 437234A PL 43723421 A PL43723421 A PL 43723421A PL 437234 A1 PL437234 A1 PL 437234A1
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PL
Poland
Prior art keywords
hap
wpi
mixture
hydroxyapatite
glucan
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Application number
PL437234A
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English (en)
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PL240639B1 (pl
Inventor
Katarzyna Klimek
Grażyna GINALSKA
Marta Tarczyńska-Osiniak
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Uniwersytet Medyczny W Lublinie
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Application filed by Uniwersytet Medyczny W Lublinie filed Critical Uniwersytet Medyczny W Lublinie
Priority to PL437234A priority Critical patent/PL240639B1/pl
Publication of PL437234A1 publication Critical patent/PL437234A1/pl
Priority to EP22719620.1A priority patent/EP4304670A1/en
Priority to US18/281,286 priority patent/US20240148939A1/en
Priority to PCT/IB2022/052002 priority patent/WO2022189937A1/en
Publication of PL240639B1 publication Critical patent/PL240639B1/pl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/3654—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Przedmiotem zgłoszenia jest biomateriał na bazie kurdlanu który stanowi β-1,3-glukan (kurdlan), izolat białka serwatkowego (WPI) oraz ceramika hydroksyapatytowa (HAp), gdzie proporcje składników polimerowych względem 100 ml wodnego roztworu wynoszą odpowiednio: 6 - 20%) (w/v) - β-1,3-glukan, 20 - 50% (w/v) - izolat białka serwatkowego (WPI), natomiast ilość dodawanych granul ceramiki hydroksyapatytowej (HAp) do takiej mieszaniny polimerów wynosi 40 g - 100 g. Zgłoszenie obejmuje także sposób wytwarzania dwufazowego biomateriału według wynalazku polega na tym, że 20 - 50% (w/v) wodny roztwór izolatu białka serwatkowego (WPI), korzystnie 30% (w/v), dodaje się do proszku β-1,3-glukan (kurdlanu), tak aby uzyskać mieszaninę, w której stężenie kurdlanu względem roztworu WPI wynosi 6 - 20% (w/v), korzystnie 8% (w/v), następnie do takiej mieszaniny dodaje się ceramikę hydroksyapatytową (HAp) w postaci nanoproszku lub proszku lub granul o rozmiarze 0,01 – 1,0 mm, wypalanych w temperaturze 500 - 1300°C w ilości 40 g - 100 g na 100 ml roztworu wodnego kurdlan-WPI, korzystnie 70 g granul wypalanych w temperaturze 1100-1200°C, po czym uzyskaną mieszaninę poddaje się wirowaniu przez 1 - 10 minut, przy prędkości 800 - 10 000 rpm, następnie mieszaninę z ufomowanymi fazami górną — polimerową oraz dolną — polimerowo - ceramiczną inkubuje się przez około 15 minut w temperaturze 90 - 120°C.
PL437234A 2021-03-08 2021-03-08 Dwufazowy biomateriał na bazie kurdlanu oraz hydroksyapatytu (HAp) oraz sposób jego otrzymywania i jego zastosowanie do regeneracji ubytków chrzęstno-kostnych PL240639B1 (pl)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PL437234A PL240639B1 (pl) 2021-03-08 2021-03-08 Dwufazowy biomateriał na bazie kurdlanu oraz hydroksyapatytu (HAp) oraz sposób jego otrzymywania i jego zastosowanie do regeneracji ubytków chrzęstno-kostnych
EP22719620.1A EP4304670A1 (en) 2021-03-08 2022-03-07 Biphasic biomaterial based on curdlan and hydroxyapatite (hap) for regeneration of osteochondral defects and the method of its preparation
US18/281,286 US20240148939A1 (en) 2021-03-08 2022-03-07 Biphasic biomaterial based on curdlan and hydroxy apatite (hap) for regeneration of osteochondral defects and the method of its preparation
PCT/IB2022/052002 WO2022189937A1 (en) 2021-03-08 2022-03-07 Biphasic biomaterial based on curdlan and hydroxyapatite (hap) for regeneration of osteochondral defects and the method of its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL437234A PL240639B1 (pl) 2021-03-08 2021-03-08 Dwufazowy biomateriał na bazie kurdlanu oraz hydroksyapatytu (HAp) oraz sposób jego otrzymywania i jego zastosowanie do regeneracji ubytków chrzęstno-kostnych

Publications (2)

Publication Number Publication Date
PL437234A1 true PL437234A1 (pl) 2021-11-22
PL240639B1 PL240639B1 (pl) 2022-05-09

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PL437234A PL240639B1 (pl) 2021-03-08 2021-03-08 Dwufazowy biomateriał na bazie kurdlanu oraz hydroksyapatytu (HAp) oraz sposób jego otrzymywania i jego zastosowanie do regeneracji ubytków chrzęstno-kostnych

Country Status (4)

Country Link
US (1) US20240148939A1 (pl)
EP (1) EP4304670A1 (pl)
PL (1) PL240639B1 (pl)
WO (1) WO2022189937A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL245926B1 (pl) * 2022-10-05 2024-11-04 Univ Medyczny W Lublinie Nanokompozytowe rusztowanie kostne na bazie matrycy kurdlanowo- chitozanowej i hydroksyapatytu oraz sposób jego wytwarzania
PL247449B1 (pl) * 2022-10-05 2025-07-07 Univ Medyczny W Lublinie Nanokompozytowy granulat hydroksyapatytowo-polimerowy na bazie matrycy kurdlanowo-chitozanowej oraz sposób jego wytwarzania

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011123760A2 (en) * 2010-04-01 2011-10-06 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Whey protein isolate hydrogels and their uses
PL237985B1 (pl) * 2020-01-08 2021-06-28 Medical Inventi Spolka Akcyjna Magnetyczny kompozyt bioaktywny oraz sposób wytwarzania magnetycznego kompozytu bioaktywnego

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PL240639B1 (pl) 2022-05-09
EP4304670A1 (en) 2024-01-17
US20240148939A1 (en) 2024-05-09
WO2022189937A1 (en) 2022-09-15

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