PL439243A1 - Nowy analog dermorfiny jako lek przeciwbólowy do stosowania w leczeniu bólu przewlekłego - Google Patents

Nowy analog dermorfiny jako lek przeciwbólowy do stosowania w leczeniu bólu przewlekłego

Info

Publication number
PL439243A1
PL439243A1 PL439243A PL43924321A PL439243A1 PL 439243 A1 PL439243 A1 PL 439243A1 PL 439243 A PL439243 A PL 439243A PL 43924321 A PL43924321 A PL 43924321A PL 439243 A1 PL439243 A1 PL 439243A1
Authority
PL
Poland
Prior art keywords
treatment
chronic pain
analgesic
dermorphine
new analogue
Prior art date
Application number
PL439243A
Other languages
English (en)
Inventor
Piotr Kosson
Joanna Matalińska
Jolanta Dyniewicz
Aleksandra MISICKA-KĘSIK
Dagmara TYMECKA
Original Assignee
Instytut Medycyny Doświadczalnej I Klinicznej Im. Mirosława Mossakowskiego Polskiej Akademii Nauk
Uniwersytet Warszawski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instytut Medycyny Doświadczalnej I Klinicznej Im. Mirosława Mossakowskiego Polskiej Akademii Nauk, Uniwersytet Warszawski filed Critical Instytut Medycyny Doświadczalnej I Klinicznej Im. Mirosława Mossakowskiego Polskiej Akademii Nauk
Priority to PL439243A priority Critical patent/PL439243A1/pl
Priority to US18/699,135 priority patent/US20250002533A1/en
Priority to EP22884148.2A priority patent/EP4419539A4/en
Priority to PCT/PL2022/050068 priority patent/WO2023068949A1/en
Publication of PL439243A1 publication Critical patent/PL439243A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Przedmiotem zgłoszenia jest peptyd hybrydowy nadający się do długotrwałego stosowania w leczeniu bólu przewlekłego, bez generowania tolerancji i w dawce co najmniej 100-krotnie niższej niż skuteczna przeciwbólowo u tego pacjenta dawka morfiny.
PL439243A 2021-10-18 2021-10-18 Nowy analog dermorfiny jako lek przeciwbólowy do stosowania w leczeniu bólu przewlekłego PL439243A1 (pl)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PL439243A PL439243A1 (pl) 2021-10-18 2021-10-18 Nowy analog dermorfiny jako lek przeciwbólowy do stosowania w leczeniu bólu przewlekłego
US18/699,135 US20250002533A1 (en) 2021-10-18 2022-10-18 Peptide and its uses
EP22884148.2A EP4419539A4 (en) 2021-10-18 2022-10-18 PEPTIDE AND ITS USES
PCT/PL2022/050068 WO2023068949A1 (en) 2021-10-18 2022-10-18 Peptide and its uses

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL439243A PL439243A1 (pl) 2021-10-18 2021-10-18 Nowy analog dermorfiny jako lek przeciwbólowy do stosowania w leczeniu bólu przewlekłego

Publications (1)

Publication Number Publication Date
PL439243A1 true PL439243A1 (pl) 2023-04-24

Family

ID=86058401

Family Applications (1)

Application Number Title Priority Date Filing Date
PL439243A PL439243A1 (pl) 2021-10-18 2021-10-18 Nowy analog dermorfiny jako lek przeciwbólowy do stosowania w leczeniu bólu przewlekłego

Country Status (4)

Country Link
US (1) US20250002533A1 (pl)
EP (1) EP4419539A4 (pl)
PL (1) PL439243A1 (pl)
WO (1) WO2023068949A1 (pl)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0350221B1 (en) * 1988-06-30 1996-04-17 Astra Aktiebolag Dermorphin analogs, their methods of preparation, pharmaceutical compositions, and methods of therapeutic treatment using the same
PL202928B1 (pl) * 2004-07-14 2009-08-31 Carr Daniel R Nowe peptydy i kompozycja farmaceutyczna oraz ich zastosowania medyczne
ITRM20040607A1 (it) * 2004-12-15 2005-03-15 Biogen S R L Analoghi della dermorfina ad attivita' analgesica.

Also Published As

Publication number Publication date
WO2023068949A1 (en) 2023-04-27
EP4419539A1 (en) 2024-08-28
US20250002533A1 (en) 2025-01-02
EP4419539A4 (en) 2025-10-22

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