PL441721A1 - Device for automated determination of an analyte in the liquid phase and method for automated determination of an analyte in the liquid phase using this device, in particular for monitoring the progress of the dialysis process - Google Patents

Device for automated determination of an analyte in the liquid phase and method for automated determination of an analyte in the liquid phase using this device, in particular for monitoring the progress of the dialysis process

Info

Publication number
PL441721A1
PL441721A1 PL441721A PL44172122A PL441721A1 PL 441721 A1 PL441721 A1 PL 441721A1 PL 441721 A PL441721 A PL 441721A PL 44172122 A PL44172122 A PL 44172122A PL 441721 A1 PL441721 A1 PL 441721A1
Authority
PL
Poland
Prior art keywords
analyte
cylinder
liquid phase
automated determination
determination
Prior art date
Application number
PL441721A
Other languages
Polish (pl)
Inventor
Łukasz Tymecki
Michał Michalec
Mateusz GRANICA
Olga KOPACKA
Łukasz JANUS
Marcin Grzeczkowicz
Agnieszka Więckowska
Justyna BZURA
Mateusz STAWICKI
Original Assignee
Microanalysis Spółka Z Ograniczoną Odpowiedzialnością
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microanalysis Spółka Z Ograniczoną Odpowiedzialnością filed Critical Microanalysis Spółka Z Ograniczoną Odpowiedzialnością
Priority to PL441721A priority Critical patent/PL441721A1/en
Priority to US18/275,011 priority patent/US20250060387A1/en
Priority to PCT/PL2023/000037 priority patent/WO2024014969A1/en
Priority to EP23745030.9A priority patent/EP4547293A1/en
Publication of PL441721A1 publication Critical patent/PL441721A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/15—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit
    • A61M1/154—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit with sensing means or components thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/11—Filling or emptying of cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/62—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving urea
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/70—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Przedmiotem zgłoszenia jest urządzenie do zautomatyzowanego oznaczenia analitu w fazie ciekłej na drodze prowadzenia specyficznej reakcji chemicznej oraz późniejszego optycznego pomiaru stężenia jej produktów, które zawiera układ hydrauliczny, w którym przestrzeń reakcyjną i przestrzeń detekcji optycznej stanowi cylinder (1), korzystnie wytworzony ze strzykawki, o ścianach transparentnych, wyposażony w dwa przeciwstawne współosiowe ruchome tłoki (2) szczelnie go zamykające z każdej strony, poruszane sterowanymi elektronicznie silnikami krokowymi, a także w układ detekcji optycznej (23) umożliwiający oznaczenie analitu bezpośrednio wewnątrz cylindra (1), przy czym cylinder (1) jest połączony ze zbiornikiem zewnętrznym zawierającym badaną próbkę, ze zbiornikami zawierającymi odczynniki chemiczne oraz z kanałem odpadowym do usuwania roztworu poreakcyjnego, dzięki czemu możliwe zaciągnięcie próbki do cylindra (1), prowadzenie reakcji chemicznej, oznaczenie analitu, a następnie usunięcie roztworu poreakcyjnego, po czym przepłukanie układu i przygotowanie go do kolejnego oznaczenia. Urządzenie zawiera wieloelementowy układ detekcji optycznej (23), który składa się ze źródła światła (24) oraz dwóch detektorów (25, 27), z których jeden (25), wykorzystywany w detekcji fotometrycznej lub turbidymetrycznej, jest położony na osi drogi optycznej źródła światła (24) po przeciwnej stronie cylindra (1), a drugi (27) wykorzystywany  w detekcji fluorymetrycznej lub nefelometrycznej, pod kątem 90° do tej osi optycznej. Możliwe jest stosowanie diodowych monochromatycznych źródeł światła dostosowanych do konkretnych analitów, a także źródeł światła o zmiennej długości fali lub źródeł światła białego dostosowanych jednocześnie do wielu analitów. Tłoczenie roztworów w układzie realizowane jest na drodze pneumatycznej, wymuszanej skoordynowanym ruchem tłoków (2). Połączenie urządzenia ze zbiornikiem analitu jest realizowane poprzez śluzę powietrzną. Przedmiotem zgłoszenia jest także sposób zautomatyzowanego oznaczania analitu w fazie ciekłej na drodze prowadzenia specyficznej reakcji chemicznej oraz późniejszego optycznego pomiaru stężenia jej produktów.The subject of the application is a device for automated determination of an analyte in the liquid phase by conducting a specific chemical reaction and subsequent optical measurement of the concentration of its products, which includes a hydraulic system in which the reaction space and the optical detection space are a cylinder (1), preferably made of a syringe, with transparent walls, equipped with two opposing coaxial movable pistons (2) tightly closing it on each side, moved by electronically controlled stepper motors, and with an optical detection system (23) enabling the determination of the analyte directly inside the cylinder (1), where the cylinder (1 ) is connected to an external tank containing the tested sample, to tanks containing chemical reagents and to a waste channel for removing the post-reaction solution, which makes it possible to draw the sample into the cylinder (1), conduct a chemical reaction, determine the analyte and then remove the post-reaction solution, and then flushing the system and preparing it for the next determination. The device contains a multi-element optical detection system (23), which consists of a light source (24) and two detectors (25, 27), one of which (25), used in photometric or turbidimetric detection, is located on the axis of the optical path of the light source (24) on the opposite side of the cylinder (1), and the other (27) used  in fluorimetric or nephelometric detection, at an angle of 90° to this optical axis. It is possible to use monochromatic diode light sources adapted to specific analytes, as well as variable wavelength light sources or white light sources adapted to many analytes simultaneously. Pumping of solutions in the system is carried out pneumatically, forced by the coordinated movement of pistons (2). The device is connected to the analyte tank via an airlock. The subject of the application is also a method of automated determination of an analyte in the liquid phase by conducting a specific chemical reaction and subsequent optical measurement of the concentration of its products.

PL441721A 2022-07-12 2022-07-12 Device for automated determination of an analyte in the liquid phase and method for automated determination of an analyte in the liquid phase using this device, in particular for monitoring the progress of the dialysis process PL441721A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PL441721A PL441721A1 (en) 2022-07-12 2022-07-12 Device for automated determination of an analyte in the liquid phase and method for automated determination of an analyte in the liquid phase using this device, in particular for monitoring the progress of the dialysis process
US18/275,011 US20250060387A1 (en) 2022-07-12 2023-07-12 A device for an automated determination of an analyte in liquid phase and a method for an automated determination of an anal yte in liquid phase using the device, in particular for monitoring a progress of a dialysis
PCT/PL2023/000037 WO2024014969A1 (en) 2022-07-12 2023-07-12 Device and method for the automated determination of an analyte in liquid phase, in particular for monitoring the progress of a dialysis
EP23745030.9A EP4547293A1 (en) 2022-07-12 2023-07-12 Device and method for the automated determination of an analyte in liquid phase, in particular for monitoring the progress of a dialysis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL441721A PL441721A1 (en) 2022-07-12 2022-07-12 Device for automated determination of an analyte in the liquid phase and method for automated determination of an analyte in the liquid phase using this device, in particular for monitoring the progress of the dialysis process

Publications (1)

Publication Number Publication Date
PL441721A1 true PL441721A1 (en) 2024-01-15

Family

ID=89543769

Family Applications (1)

Application Number Title Priority Date Filing Date
PL441721A PL441721A1 (en) 2022-07-12 2022-07-12 Device for automated determination of an analyte in the liquid phase and method for automated determination of an analyte in the liquid phase using this device, in particular for monitoring the progress of the dialysis process

Country Status (1)

Country Link
PL (1) PL441721A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL445552A1 (en) * 2023-07-11 2025-01-13 Microanalysis Spółka Z Ograniczoną Odpowiedzialnością Reaction-detection system with replaceable cartridge for a device for automated determination of an analyte in the liquid phase and a method for automated determination of an analyte in the liquid phase using this system, especially for monitoring the progress of the dialysis process
PL445551A1 (en) * 2023-07-11 2025-01-13 Microanalysis Spółka Z Ograniczoną Odpowiedzialnością Reaction-detection system with replaceable cartridge for a device for automated determination of an analyte in the liquid phase and a method for automated determination of an analyte in the liquid phase using this system, especially for monitoring the progress of the dialysis process

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09229929A (en) * 1996-02-27 1997-09-05 Toto Ltd Analyzer
JP2003232724A (en) * 2002-02-07 2003-08-22 Dkk Toa Corp Analysis unit
WO2009035008A1 (en) * 2007-09-13 2009-03-19 Okayama Prefecture Industrial Promotion Foundation Method of measuring chemiluminescence and chemiluminescence measuring apparatus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09229929A (en) * 1996-02-27 1997-09-05 Toto Ltd Analyzer
JP2003232724A (en) * 2002-02-07 2003-08-22 Dkk Toa Corp Analysis unit
WO2009035008A1 (en) * 2007-09-13 2009-03-19 Okayama Prefecture Industrial Promotion Foundation Method of measuring chemiluminescence and chemiluminescence measuring apparatus

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL445552A1 (en) * 2023-07-11 2025-01-13 Microanalysis Spółka Z Ograniczoną Odpowiedzialnością Reaction-detection system with replaceable cartridge for a device for automated determination of an analyte in the liquid phase and a method for automated determination of an analyte in the liquid phase using this system, especially for monitoring the progress of the dialysis process
PL445551A1 (en) * 2023-07-11 2025-01-13 Microanalysis Spółka Z Ograniczoną Odpowiedzialnością Reaction-detection system with replaceable cartridge for a device for automated determination of an analyte in the liquid phase and a method for automated determination of an analyte in the liquid phase using this system, especially for monitoring the progress of the dialysis process

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