PL444904A1 - Nowe pochodne 4,6-dimetylo-2-sulfanylopirydyny sprzężone z pierścieniem 1,2,4-triazolu, sposób syntezy pochodnych oraz zastosowanie pochodnych - Google Patents

Nowe pochodne 4,6-dimetylo-2-sulfanylopirydyny sprzężone z pierścieniem 1,2,4-triazolu, sposób syntezy pochodnych oraz zastosowanie pochodnych

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Publication number
PL444904A1
PL444904A1 PL444904A PL44490423A PL444904A1 PL 444904 A1 PL444904 A1 PL 444904A1 PL 444904 A PL444904 A PL 444904A PL 44490423 A PL44490423 A PL 44490423A PL 444904 A1 PL444904 A1 PL 444904A1
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PL
Poland
Prior art keywords
derivatives
sulfanylpyridine
conjugated
dimethyl
application
Prior art date
Application number
PL444904A
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English (en)
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PL248780B1 (pl
Inventor
Małgorzata Strzelecka
Benita WIATRAK
Piotr ŚWIĄTEK
Original Assignee
Uniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu
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Application filed by Uniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu filed Critical Uniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu
Priority to PL444904A priority Critical patent/PL248780B1/pl
Publication of PL444904A1 publication Critical patent/PL444904A1/pl
Publication of PL248780B1 publication Critical patent/PL248780B1/pl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pierwszym przedmiotem zgłoszenia jest nowa pochodna 4,6-dimetylo-2-sulfanylopirydyny sprzężone z pierścieniem 1,2,4-triazolu, przedstawiona wzorem ogólnym (I). Ponadto, wynalazek obejmuje sposób otrzymywania nowej pochodnej 4 o wzorze ogólnym (I), jej zastosowanie do leczenia chorób nowotworowych oraz do otrzymywania kompozycji leczniczych.
PL444904A 2023-05-15 2023-05-15 Nowe pochodne 4,6-dimetylo-2-sulfanylopirydyny sprzężone z pierścieniem 1,2,4-triazolu, sposób syntezy pochodnych oraz zastosowanie pochodnych PL248780B1 (pl)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL444904A PL248780B1 (pl) 2023-05-15 2023-05-15 Nowe pochodne 4,6-dimetylo-2-sulfanylopirydyny sprzężone z pierścieniem 1,2,4-triazolu, sposób syntezy pochodnych oraz zastosowanie pochodnych

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL444904A PL248780B1 (pl) 2023-05-15 2023-05-15 Nowe pochodne 4,6-dimetylo-2-sulfanylopirydyny sprzężone z pierścieniem 1,2,4-triazolu, sposób syntezy pochodnych oraz zastosowanie pochodnych

Publications (2)

Publication Number Publication Date
PL444904A1 true PL444904A1 (pl) 2024-11-18
PL248780B1 PL248780B1 (pl) 2026-01-26

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ID=93522705

Family Applications (1)

Application Number Title Priority Date Filing Date
PL444904A PL248780B1 (pl) 2023-05-15 2023-05-15 Nowe pochodne 4,6-dimetylo-2-sulfanylopirydyny sprzężone z pierścieniem 1,2,4-triazolu, sposób syntezy pochodnych oraz zastosowanie pochodnych

Country Status (1)

Country Link
PL (1) PL248780B1 (pl)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004096781A1 (en) * 2003-04-25 2004-11-11 Astrazeneca Ab Use of derivatives of 2, 4-dihydro-[1,2,4]triazole-3-thione as inhibitors o fteh enzyme myeloperoxidase (mpo)
WO2005039569A1 (en) * 2003-10-18 2005-05-06 Bayer Healthcare Ag 5-substituted 2-(phenylmethyl) thio-4-phenyl-4h-1,2,4-triazole derivatives and related compounds as gaba-agonists for the treatment of urinary incontinence and related diseases
US20060100235A1 (en) * 2003-04-11 2006-05-11 Novo Nordisk A/S Pharmaceutical use of substituted 1,2,4-triazoles

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060100235A1 (en) * 2003-04-11 2006-05-11 Novo Nordisk A/S Pharmaceutical use of substituted 1,2,4-triazoles
WO2004096781A1 (en) * 2003-04-25 2004-11-11 Astrazeneca Ab Use of derivatives of 2, 4-dihydro-[1,2,4]triazole-3-thione as inhibitors o fteh enzyme myeloperoxidase (mpo)
WO2005039569A1 (en) * 2003-10-18 2005-05-06 Bayer Healthcare Ag 5-substituted 2-(phenylmethyl) thio-4-phenyl-4h-1,2,4-triazole derivatives and related compounds as gaba-agonists for the treatment of urinary incontinence and related diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MOHAMMED B. WATHIQ AL-TAMIMI.: "International Journal of Health Sciences, August 2022, 7185-7203", SYNTHESIS, IDENTIFICATION OF SOME NEW 1,2,4-TRIAZOLE DERIVATIVES FROM 6-AMINO-1,3-DIMETHYLURACIL AND EVALUATION OF THEIR MOLECULAR DOCKING, ANTI-OXIDANT AND EXPERIMENTAL *

Also Published As

Publication number Publication date
PL248780B1 (pl) 2026-01-26

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