PL445986A1 - Hydrophilic polymeric biomaterial in the form of a hydrogel for strengthening the nucleus pulposus of the spine and its production method - Google Patents

Hydrophilic polymeric biomaterial in the form of a hydrogel for strengthening the nucleus pulposus of the spine and its production method

Info

Publication number
PL445986A1
PL445986A1 PL445986A PL44598623A PL445986A1 PL 445986 A1 PL445986 A1 PL 445986A1 PL 445986 A PL445986 A PL 445986A PL 44598623 A PL44598623 A PL 44598623A PL 445986 A1 PL445986 A1 PL 445986A1
Authority
PL
Poland
Prior art keywords
hydrogel
spine
strengthening
production method
nucleus pulposus
Prior art date
Application number
PL445986A
Other languages
Polish (pl)
Inventor
Michał Wojasiński
Piotr Kowalczyk
Ewa Walejewska
Ewa Kijeńska-Gawrońska
Tomasz CIACH
Original Assignee
Politechnika Warszawska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Politechnika Warszawska filed Critical Politechnika Warszawska
Priority to PL445986A priority Critical patent/PL445986A1/en
Publication of PL445986A1 publication Critical patent/PL445986A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/3654—Cartilage, e.g. meniscus
    • A61L27/3658—Intervertebral discs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest hydrofilowy biomateriał polimerowy w postaci hydrożelu do wzmacniania jądra miażdżystego kręgosłupa charakteryzujący się tym, że zawiera podwójnie usieciowany kopolimer poliwinylopirolidonu, chitozanu i poli(glikolu etylenowego) o strukturze kopolimeru statystycznego, przy czym stężenie masowe poliwinylopirolidonu zawiera się w zakresie od 7,5% do 12%, stężenie masowe chitozanu zawiera się w zakresie od 1,5% do 2,5 %, a stężenie masowe poli(glikolu etylenowego) wynosi 1%, w odniesieniu do całkowitej masy biomateriału oraz sposób jego wytwarzania.The subject of the application is a hydrophilic polymeric biomaterial in the form of a hydrogel for strengthening the nucleus pulposus of the spine, characterized by the fact that it contains a double cross-linked copolymer of polyvinylpyrrolidone, chitosan and poly(ethylene glycol) with a random copolymer structure, where the mass concentration of polyvinylpyrrolidone is in the range of 7.5 % to 12%, the mass concentration of chitosan ranges from 1.5% to 2.5%, and the mass concentration of poly(ethylene glycol) is 1%, based on the total mass of the biomaterial and its production method.

PL445986A 2023-09-01 2023-09-01 Hydrophilic polymeric biomaterial in the form of a hydrogel for strengthening the nucleus pulposus of the spine and its production method PL445986A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL445986A PL445986A1 (en) 2023-09-01 2023-09-01 Hydrophilic polymeric biomaterial in the form of a hydrogel for strengthening the nucleus pulposus of the spine and its production method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL445986A PL445986A1 (en) 2023-09-01 2023-09-01 Hydrophilic polymeric biomaterial in the form of a hydrogel for strengthening the nucleus pulposus of the spine and its production method

Publications (1)

Publication Number Publication Date
PL445986A1 true PL445986A1 (en) 2024-01-29

Family

ID=89719891

Family Applications (1)

Application Number Title Priority Date Filing Date
PL445986A PL445986A1 (en) 2023-09-01 2023-09-01 Hydrophilic polymeric biomaterial in the form of a hydrogel for strengthening the nucleus pulposus of the spine and its production method

Country Status (1)

Country Link
PL (1) PL445986A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992010982A1 (en) * 1990-12-21 1992-07-09 Howmedica Inc. Hydrogel intervertebral disc nucleus
US10507264B1 (en) * 2019-01-07 2019-12-17 Regeltec, Inc. Cross-linked hydrogels and method of making the same
US20220193306A1 (en) * 2019-01-07 2022-06-23 Regeltec, Inc. Hydrogels and method of making the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992010982A1 (en) * 1990-12-21 1992-07-09 Howmedica Inc. Hydrogel intervertebral disc nucleus
US10507264B1 (en) * 2019-01-07 2019-12-17 Regeltec, Inc. Cross-linked hydrogels and method of making the same
US20220193306A1 (en) * 2019-01-07 2022-06-23 Regeltec, Inc. Hydrogels and method of making the same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CAIPING YAN ET AL., "APPLICATIONS OF FUNCTIONALIZED HYDROGELS IN THE REGENERATION OF THE INTERVERTEBRAL DISC", BIOMED RESEARCH INTERNATIONAL, VOLUME 2021, ARTICLE ID 2818624, 19 P. *
HUIZI ANNA LIN ET AL., "INJECTABLE CELLULOSE-BASED HYDROGELS AS NUCLEUS PULPOSUS REPLACEMENTS: ASSESSMENT OF IN VITRO STRUCTURAL STABILITY, EX VIVO HERNIATION RISK, AND IN VIVO BIOCOMPATIBILITY",J MECH BEHAV BIOMED MATER. 2019 AUG; 96: 204–213. *
LINJUN YANG ET AL., "DUAL-DYNAMIC-BOND CROSS-LINKED INJECTABLE HYDROGEL OF MULTIFUNCTION FOR INTERVERTEBRAL DISC DEGENERATION THERAPY", JOURNAL OF NANOBIOTECHNOLOGY VOLUME 20, ARTICLE NUMBER: 433 *

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