PL447656A1 - New quaternary ammonium salts containing an anion derived from nicotinic acid and an N-alkylnicotinamide cation, method for obtaining them and their use as substances with antibacterial activity - Google Patents

New quaternary ammonium salts containing an anion derived from nicotinic acid and an N-alkylnicotinamide cation, method for obtaining them and their use as substances with antibacterial activity

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Publication number
PL447656A1
PL447656A1 PL447656A PL44765624A PL447656A1 PL 447656 A1 PL447656 A1 PL 447656A1 PL 447656 A PL447656 A PL 447656A PL 44765624 A PL44765624 A PL 44765624A PL 447656 A1 PL447656 A1 PL 447656A1
Authority
PL
Poland
Prior art keywords
alkylnicotinamide
cation
substances
obtaining
quaternary ammonium
Prior art date
Application number
PL447656A
Other languages
Polish (pl)
Inventor
Tomasz Rzemieniecki
Adriana Olejniczak
Witold Stachowiak
Michał NIEMCZAK
Original Assignee
Politechnika Poznańska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Politechnika Poznańska filed Critical Politechnika Poznańska
Priority to PL447656A priority Critical patent/PL447656A1/en
Publication of PL447656A1 publication Critical patent/PL447656A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Environmental Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia są nowe czwartorzędowe sole amoniowe zawierające anion pochodzący od kwasu nikotynowego oraz kation N-alkilonikotynamidu, o wzorze ogólnym 1, w którym R oznacza nierozgałęziony podstawnik alkilowy z wiązaniami nasyconymi zawierający od 6 do 12 atomów węgla, sposób ich otrzymywania oraz zastosowanie jako substancje o aktywności przeciwbakteryjnej.The subject of the application is new quaternary ammonium salts containing an anion derived from nicotinic acid and an N-alkylnicotinamide cation, of the general formula 1, wherein R is an unbranched alkyl substituent with saturated bonds containing from 6 to 12 carbon atoms, a method of obtaining them and their use as substances with antibacterial activity.

PL447656A 2024-01-31 2024-01-31 New quaternary ammonium salts containing an anion derived from nicotinic acid and an N-alkylnicotinamide cation, method for obtaining them and their use as substances with antibacterial activity PL447656A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL447656A PL447656A1 (en) 2024-01-31 2024-01-31 New quaternary ammonium salts containing an anion derived from nicotinic acid and an N-alkylnicotinamide cation, method for obtaining them and their use as substances with antibacterial activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL447656A PL447656A1 (en) 2024-01-31 2024-01-31 New quaternary ammonium salts containing an anion derived from nicotinic acid and an N-alkylnicotinamide cation, method for obtaining them and their use as substances with antibacterial activity

Publications (1)

Publication Number Publication Date
PL447656A1 true PL447656A1 (en) 2025-08-04

Family

ID=96584800

Family Applications (1)

Application Number Title Priority Date Filing Date
PL447656A PL447656A1 (en) 2024-01-31 2024-01-31 New quaternary ammonium salts containing an anion derived from nicotinic acid and an N-alkylnicotinamide cation, method for obtaining them and their use as substances with antibacterial activity

Country Status (1)

Country Link
PL (1) PL447656A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005067927A2 (en) * 2004-01-12 2005-07-28 Pharmena Sp Z O.O. The use of quaternary pyridinium salts as vasoprotective agents
WO2007065281A1 (en) * 2005-12-09 2007-06-14 Cerecon Ag Quaternary 3 -amido, n-methylpyridinium salts as anti -inflammatory agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005067927A2 (en) * 2004-01-12 2005-07-28 Pharmena Sp Z O.O. The use of quaternary pyridinium salts as vasoprotective agents
WO2007065281A1 (en) * 2005-12-09 2007-06-14 Cerecon Ag Quaternary 3 -amido, n-methylpyridinium salts as anti -inflammatory agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BUŠIĆ, V., VRANDEČIĆ, K., SIBER, T., ROCA, S., TOMIČIĆ, V. & GAŠO- SOKAČ, D.,: "Croatica chemica acta, 2022, 95 (1), 31-38", "NOVEL SYNTHETIC ROUTES TO QUATERNARY PYRIDINIUM SALTS AND THEIR ANTIFUNGAL ACTIVITY" *

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