PL447909A1 - Sposób otrzymywania itrakonazolu w stabilnej fazie nematycznej - Google Patents

Sposób otrzymywania itrakonazolu w stabilnej fazie nematycznej

Info

Publication number
PL447909A1
PL447909A1 PL447909A PL44790924A PL447909A1 PL 447909 A1 PL447909 A1 PL 447909A1 PL 447909 A PL447909 A PL 447909A PL 44790924 A PL44790924 A PL 44790924A PL 447909 A1 PL447909 A1 PL 447909A1
Authority
PL
Poland
Prior art keywords
itraconazole
nematic phase
obtaining
time
stable nematic
Prior art date
Application number
PL447909A
Other languages
English (en)
Inventor
Karolina Jurkiewicz
Taoufik Lamrani
Paulina Jesionek
Kamil KAMIŃSKI
Ewa Ozimina-Kamińska
Original Assignee
Uniwersytet Śląski W Katowicach
Śląski Uniwersytet Medyczny W Katowicach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Śląski W Katowicach, Śląski Uniwersytet Medyczny W Katowicach filed Critical Uniwersytet Śląski W Katowicach
Priority to PL447909A priority Critical patent/PL447909A1/pl
Publication of PL447909A1 publication Critical patent/PL447909A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób otrzymywania itrakonazolu w stabilnej fazie nematycznej polegający na tym, że materiał wyjściowy stanowiący itrakonazol o strukturalnym wzorze 1 umieszcza się w komorze młyna mechanicznego, po czym poddaje się go co najmniej jednemu cyklowi mielenia mechanicznego, korzystnie co najmniej kilkunastu cyklom mielenia mechanicznego, z częstotliwością uderzeń co najmniej 10 Hz, dobierając parametry procesu tak, aby temperatura materiału mielonego nie przekraczała 438 K, przy czym czas pojedynczego cyklu wynosi co najmniej 1 minutę, a całkowity czas mielenia jest krótszy niż czas, w którym następuje rozpad chemiczny itrakonazolu lub jego przejście do innej niż nematyczna fazy strukturalnej.
PL447909A 2024-03-01 2024-03-01 Sposób otrzymywania itrakonazolu w stabilnej fazie nematycznej PL447909A1 (pl)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL447909A PL447909A1 (pl) 2024-03-01 2024-03-01 Sposób otrzymywania itrakonazolu w stabilnej fazie nematycznej

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL447909A PL447909A1 (pl) 2024-03-01 2024-03-01 Sposób otrzymywania itrakonazolu w stabilnej fazie nematycznej

Publications (1)

Publication Number Publication Date
PL447909A1 true PL447909A1 (pl) 2025-09-08

Family

ID=96946642

Family Applications (1)

Application Number Title Priority Date Filing Date
PL447909A PL447909A1 (pl) 2024-03-01 2024-03-01 Sposób otrzymywania itrakonazolu w stabilnej fazie nematycznej

Country Status (1)

Country Link
PL (1) PL447909A1 (pl)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998057967A1 (en) * 1997-06-16 1998-12-23 Dong-A Pharmaceutical Co., Ltd. An itraconazole exhibiting an improved solubility, a method of preparing the same and a pharmaceutical composition for oral administration comprising the same
PL442002A1 (pl) * 2022-08-11 2024-02-12 Uniwersytet Śląski W Katowicach Sposób otrzymywania II formy polimorficznej itrakonazolu

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998057967A1 (en) * 1997-06-16 1998-12-23 Dong-A Pharmaceutical Co., Ltd. An itraconazole exhibiting an improved solubility, a method of preparing the same and a pharmaceutical composition for oral administration comprising the same
PL442002A1 (pl) * 2022-08-11 2024-02-12 Uniwersytet Śląski W Katowicach Sposób otrzymywania II formy polimorficznej itrakonazolu

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KNAPIK-KOWALCZUK J, KRAMARCZYK D, JACHOWICZ R, PALUCH M: "J Pharm Sci. 2023 Jun;112(6):1644-1652", EFFECT OF SHEAR STRAIN ON THE SUPERCOOLED ITRACONAZOLE, DOI: 10.1016/j.xphs.2023.01.020 *

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