PL448475A1 - Pochodna tiazolu, jej zastosowanie oraz sposób jej otrzymywania - Google Patents

Pochodna tiazolu, jej zastosowanie oraz sposób jej otrzymywania

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Publication number
PL448475A1
PL448475A1 PL448475A PL44847524A PL448475A1 PL 448475 A1 PL448475 A1 PL 448475A1 PL 448475 A PL448475 A PL 448475A PL 44847524 A PL44847524 A PL 44847524A PL 448475 A1 PL448475 A1 PL 448475A1
Authority
PL
Poland
Prior art keywords
dihydro
ethyl
methyl
dioxepin
hydrazono
Prior art date
Application number
PL448475A
Other languages
English (en)
Other versions
PL249588B1 (pl
Inventor
Krzysztof Zbigniew Łączkowski
Dominika Kołodziej-Sobczak
Original Assignee
Uniwersytet Mikołaja Kopernika W Toruniu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Mikołaja Kopernika W Toruniu filed Critical Uniwersytet Mikołaja Kopernika W Toruniu
Priority to PL448475A priority Critical patent/PL249588B1/pl
Publication of PL448475A1 publication Critical patent/PL448475A1/pl
Publication of PL249588B1 publication Critical patent/PL249588B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest pochodna tiazolu będąca 5-(1-(2-(4-(3,4-dihydro-2H-benzo[b][1,4]dioksepin-7-ylo)tiazol-2-ylo)hydrazono)etylo)-2-hydroksy-benzoesanem metylu o wzorze 1. Przedmiotem zgłoszenia jest także pochodna tiazolu będąca 5-(1-(2-(4-(3,4-dihydro-2H-benzo[b][1,4]dioksepin-7-ylo)tiazol-2-ylo)hydrazono)etylo)-2-hydroksy-benzoesanem metylu o wzorze 1 do zastosowania jako składnik leków oraz do zastosowania jako inhibitor białkowej fosfatazy tyrozynowej 1B. Przedmiotem zgłoszenia jest także sposób otrzymywania 5-(1-(2-(4-(3,4-dihydro-2H-benzo[b][1,4]dioksepin-7-ylo)tiazol-2-ylo)hydrazono)etylo)-2-hydroksy-benzoesanu metylu o wzorze 1, charakteryzujący się tym, że 5-(1-(2-karbamotioylohydrazono)etylo)-2-hydroksybenzoesan metylu poddaje się reakcji w atmosferze azotu lub argonu z 2-bromo-1-(3,4-dihydro-2H-1,5-benzodioksepin-7-ylo)etanonem w stosunku 1:1 poddając mieszaniu w temperaturze wrzenia rozpuszczalnika, a następnie po ochłodzeniu roztworu otrzymany produkt wydziela się w procesie sączenia z użyciem zestawu do filtracji próżniowej z lejkiem Buchnera, a następnie produkt poddaje się oczyszczaniu w procesie chromatografii kolumnowej z użyciem eluentu dichlorometanu i metanolu w stosunku od 90:10 do 98:2, korzystnie 95:5.
PL448475A 2024-05-02 2024-05-02 Pochodna tiazolu, jej zastosowanie oraz sposób jej otrzymywania PL249588B1 (pl)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL448475A PL249588B1 (pl) 2024-05-02 2024-05-02 Pochodna tiazolu, jej zastosowanie oraz sposób jej otrzymywania

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL448475A PL249588B1 (pl) 2024-05-02 2024-05-02 Pochodna tiazolu, jej zastosowanie oraz sposób jej otrzymywania

Publications (2)

Publication Number Publication Date
PL448475A1 true PL448475A1 (pl) 2025-11-03
PL249588B1 PL249588B1 (pl) 2026-05-18

Family

ID=97522440

Family Applications (1)

Application Number Title Priority Date Filing Date
PL448475A PL249588B1 (pl) 2024-05-02 2024-05-02 Pochodna tiazolu, jej zastosowanie oraz sposób jej otrzymywania

Country Status (1)

Country Link
PL (1) PL249588B1 (pl)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1868604B1 (en) * 2005-01-21 2014-08-13 President and Fellows of Harvard College Regulation of protein synthesis by inhibition of eif4e-eif4g interaction

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1868604B1 (en) * 2005-01-21 2014-08-13 President and Fellows of Harvard College Regulation of protein synthesis by inhibition of eif4e-eif4g interaction

Also Published As

Publication number Publication date
PL249588B1 (pl) 2026-05-18

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