PL449471A1 - Biocompatible oil-in-water nanoemulsion and preparation method thereof - Google Patents

Biocompatible oil-in-water nanoemulsion and preparation method thereof

Info

Publication number
PL449471A1
PL449471A1 PL449471A PL44947124A PL449471A1 PL 449471 A1 PL449471 A1 PL 449471A1 PL 449471 A PL449471 A PL 449471A PL 44947124 A PL44947124 A PL 44947124A PL 449471 A1 PL449471 A1 PL 449471A1
Authority
PL
Poland
Prior art keywords
coconut
oil
poe
nanoemulsion
weight
Prior art date
Application number
PL449471A
Other languages
Polish (pl)
Inventor
Urszula Bazylińska
Aleksandra Szarwaryn
Original Assignee
Politechnika Wrocławska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Politechnika Wrocławska filed Critical Politechnika Wrocławska
Priority to PL449471A priority Critical patent/PL449471A1/en
Publication of PL449471A1 publication Critical patent/PL449471A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/068—Microemulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/21—Emulsions characterized by droplet sizes below 1 micron
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Colloid Chemistry (AREA)

Abstract

Zgłoszenie ujawnia biokompatybilną nanoemulsję typu olej w wodzie, która składa się z emulgatora, który stanowi od 1% wag. do 15% wag. należącego do grupy etoksylowanych amin kokosowych o wzorze ogólnym 1, w którym R1 oznacza grupy alkilowe pochodzące z oleju kokosowego, a długość łańcucha alkilowego dla POE (15) aminy kokosowej wynosi od C12-C18, wartość n + m dla POE (15) aminy kokosowej wynosi 15 i oznacza liczbę etoksylacji oraz z fazy olejowej, która stanowi od 0,1% wag. do 9% wag. i fazy wodnej w zakresie od 76% do 99% wag. Zgłoszenie ujawnia również sposób wytwarzania biokompatybilnej nanoemulsji typu olej w wodzie, która składa się z emulgatora, który stanowi od 1% wag. do 15% wag. należącego do grupy etoksylowanych amin kokosowych o wzorze ogólnym 1, w którym R1 oznacza grupy alkilowe pochodzące z oleju kokosowego, a długość łańcucha alkilowego dla POE (15) aminy kokosowej wynosi od C12-C18, wartość n + m dla POE (15) aminy kokosowej wynosi 15 i oznacza liczbę etoksylacji oraz z fazy olejowej, która stanowi od 0,1% wag. do 9% wag. i fazy wodnej w zakresie od 76% do 99% wag., polegający na tym, że składniki te łączy się ze sobą i poddaje się działaniu ultradźwięków przez 10 - 30 min w temperaturze pokojowej, uzyskując tym samym półprzezroczystą nanoemulsję.The application discloses a biocompatible oil-in-water nanoemulsion that comprises an emulsifier that comprises from 1 wt.% to 15 wt.% belonging to the group of ethoxylated coconut amines of general formula 1, wherein R1 represents alkyl groups derived from coconut oil, and the alkyl chain length for POE (15) coconut amine is from C12-C18, the n + m value for POE (15) coconut amine is 15 and represents the ethoxylation number, and an oil phase that comprises from 0.1 wt.% to 9 wt.% and a water phase in the range of from 76% to 99 wt.%. The application also discloses a method for preparing a biocompatible oil-in-water nanoemulsion that comprises an emulsifier that comprises from 1 wt.% to 15 wt.%. belonging to the group of ethoxylated coconut amines of general formula 1, wherein R1 denotes alkyl groups derived from coconut oil, and the alkyl chain length for POE (15) coconut amine is from C12-C18, the value of n + m for POE (15) coconut amine is 15 and denotes the ethoxylation number, and an oil phase which constitutes from 0.1% by weight to 9% by weight and a water phase in the range from 76% to 99% by weight, consisting in that these components are combined together and subjected to the action of ultrasound for 10 - 30 minutes at room temperature, thereby obtaining a translucent nanoemulsion.

PL449471A 2024-08-07 2024-08-07 Biocompatible oil-in-water nanoemulsion and preparation method thereof PL449471A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL449471A PL449471A1 (en) 2024-08-07 2024-08-07 Biocompatible oil-in-water nanoemulsion and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL449471A PL449471A1 (en) 2024-08-07 2024-08-07 Biocompatible oil-in-water nanoemulsion and preparation method thereof

Publications (1)

Publication Number Publication Date
PL449471A1 true PL449471A1 (en) 2026-02-09

Family

ID=98694609

Family Applications (1)

Application Number Title Priority Date Filing Date
PL449471A PL449471A1 (en) 2024-08-07 2024-08-07 Biocompatible oil-in-water nanoemulsion and preparation method thereof

Country Status (1)

Country Link
PL (1) PL449471A1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2820976A1 (en) * 2001-02-21 2002-08-23 Rhodia Chimie Sa Cosmetic or dermatological formulation comprising two or more types of active matter in a multiple emulsion consisting of an internal aqueous phase dispersed in an internal oily phase dispersed in an external aqueous phase
WO2002080864A1 (en) * 2001-03-30 2002-10-17 Color Access, Inc. Novel nanoemulsions
US20040115159A1 (en) * 2002-03-29 2004-06-17 Tadlock Charles C Novel nanoemulsions
WO2023203483A1 (en) * 2022-04-19 2023-10-26 Surcos impact Chlor-triazine nanoemulsions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2820976A1 (en) * 2001-02-21 2002-08-23 Rhodia Chimie Sa Cosmetic or dermatological formulation comprising two or more types of active matter in a multiple emulsion consisting of an internal aqueous phase dispersed in an internal oily phase dispersed in an external aqueous phase
WO2002080864A1 (en) * 2001-03-30 2002-10-17 Color Access, Inc. Novel nanoemulsions
US20040115159A1 (en) * 2002-03-29 2004-06-17 Tadlock Charles C Novel nanoemulsions
WO2023203483A1 (en) * 2022-04-19 2023-10-26 Surcos impact Chlor-triazine nanoemulsions

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