PL449564A1 - Macroporous bone implant based on calcium-magnesium zeolite CaMg-Xs functionalized with chitosan and method of its production - Google Patents
Macroporous bone implant based on calcium-magnesium zeolite CaMg-Xs functionalized with chitosan and method of its productionInfo
- Publication number
- PL449564A1 PL449564A1 PL449564A PL44956424A PL449564A1 PL 449564 A1 PL449564 A1 PL 449564A1 PL 449564 A PL449564 A PL 449564A PL 44956424 A PL44956424 A PL 44956424A PL 449564 A1 PL449564 A1 PL 449564A1
- Authority
- PL
- Poland
- Prior art keywords
- chitosan
- camg
- nanopowder
- powder
- bone implant
- Prior art date
Links
- 229920001661 Chitosan Polymers 0.000 title abstract 6
- 210000000988 bone and bone Anatomy 0.000 title abstract 5
- 239000007943 implant Substances 0.000 title abstract 5
- 229910021536 Zeolite Inorganic materials 0.000 title abstract 4
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 title abstract 4
- 239000010457 zeolite Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- ZFXVRMSLJDYJCH-UHFFFAOYSA-N calcium magnesium Chemical compound [Mg].[Ca] ZFXVRMSLJDYJCH-UHFFFAOYSA-N 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 9
- 239000011858 nanopowder Substances 0.000 abstract 6
- 239000000843 powder Substances 0.000 abstract 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 4
- 229920000936 Agarose Polymers 0.000 abstract 3
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 3
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 3
- 239000012620 biological material Substances 0.000 abstract 2
- 210000000963 osteoblast Anatomy 0.000 abstract 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 2
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 2
- 208000010392 Bone Fractures Diseases 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
- 238000012792 lyophilization process Methods 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 238000010883 osseointegration Methods 0.000 abstract 1
- 239000002504 physiological saline solution Substances 0.000 abstract 1
- 239000003361 porogen Substances 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/365—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
Abstract
Przedmiotem zgłoszenia jest makroporowaty implant kostny, który charakteryzuje się tym, że stanowi go chitozan, agaroza, hydroksyapatyt w postaci proszku lub nanoproszku oraz zeolit CaMg-X sfunkcjonalizowanego za pomocą chitozanu (CaMg-X-chitozan) w postaci proszku lub nanoproszku, rozprowadzone w 2% (v/v) wodnym roztworze kwasu octowego, przy czym proporcje wagowe stałych komponentów wynoszą odpowiednio 2% (w/v) chitozanu, 5% (w/v) agarozy, 20% (w/v) hydroksyapatytu w postaci proszku lub nanoproszku oraz 20% (w/v) zeolitu CaMg-X-chitozan w postaci proszku lub nanoproszku w odniesieniu do kwasu octowego. Zgłoszenie obejmuje także sposób wytwarzania implantu kostnego według wynalazku, który polega na tym, że agarozę, hydroksyapatyt w postaci proszku lub nanoproszku oraz zeolit CaMg-X sfunkcjonalizowany za pomocą chitozanu (CaMg-X-chitozan) w postaci proszku lub nanoproszku rozprowadza się w roztworze chitozanu przygotowanym w kwasie octowym. Następnie do jednolitej masy dodaje się wodorowęglan sodu (NaHCO3) jako porogen. Otrzymany rodzaj pasty poddaje się działaniu wysokiej temperatury, a następnie zamrożeniu oraz procesowi liofilizacji. Po liofilizacji, otrzymany biomateriał namacza się w buforowanym roztworze soli fizjologicznej (PBS) i suszy na powietrzu. Otrzymany według wynalazku implant kostny charakteryzuje się wysokoporowatą mikrostrukturą, jest nietoksyczny oraz sprzyja adhezji i proliferacji osteoblastów na jego powierzchni. Otrzymany według wynalazku biomateriał może znaleźć zastosowanie jako implant kostny do leczenia złamań kości o różnej etiologii, gdzie będzie wspierał adhezję osteoblastów (komórek kościotwórczych) i ich aktywność kościotwórczą, a tym samym proces osseointegracji.The subject of the application is a macroporous bone implant, which is characterized in that it consists of chitosan, agarose, hydroxyapatite in the form of powder or nanopowder and CaMg-X zeolite functionalized with chitosan (CaMg-X-chitosan) in the form of powder or nanopowder, distributed in a 2% (v/v) aqueous solution of acetic acid, wherein the weight proportions of the solid components are 2% (w/v) chitosan, 5% (w/v) agarose, 20% (w/v) hydroxyapatite in the form of powder or nanopowder and 20% (w/v) CaMg-X-chitosan zeolite in the form of powder or nanopowder in relation to acetic acid, respectively. The application also includes a method of producing a bone implant according to the invention, which consists in distributing agarose, hydroxyapatite in the form of powder or nanopowder and CaMg-X zeolite functionalized with chitosan (CaMg-X-chitosan) in the form of powder or nanopowder in a chitosan solution prepared in acetic acid. Then, sodium bicarbonate (NaHCO3) is added to the homogeneous mass as a porogen. The obtained type of paste is subjected to high temperature, then freezing and the lyophilization process. After lyophilization, the obtained biomaterial is soaked in a buffered physiological saline solution (PBS) and air-dried. The bone implant obtained according to the invention is characterized by a highly porous microstructure, is non-toxic and promotes the adhesion and proliferation of osteoblasts on its surface. The biomaterial obtained according to the invention can be used as a bone implant for the treatment of bone fractures of various etiologies, where it will support the adhesion of osteoblasts (bone-forming cells) and their bone-forming activity, and thus the osseointegration process.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL449564A PL449564A1 (en) | 2024-08-22 | 2024-08-22 | Macroporous bone implant based on calcium-magnesium zeolite CaMg-Xs functionalized with chitosan and method of its production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL449564A PL449564A1 (en) | 2024-08-22 | 2024-08-22 | Macroporous bone implant based on calcium-magnesium zeolite CaMg-Xs functionalized with chitosan and method of its production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL449564A1 true PL449564A1 (en) | 2025-04-22 |
Family
ID=95451071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL449564A PL449564A1 (en) | 2024-08-22 | 2024-08-22 | Macroporous bone implant based on calcium-magnesium zeolite CaMg-Xs functionalized with chitosan and method of its production |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL449564A1 (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL235822B1 (en) * | 2018-08-24 | 2020-11-02 | Univ Medyczny W Lublinie | Cryogel bone scaffold based on chitosan and calcium phosphate bioceramics as well as method of producing it |
| PL242079B1 (en) * | 2020-10-29 | 2023-01-16 | Politechnika Poznańska | Titanium material for an implant and method for its production |
-
2024
- 2024-08-22 PL PL449564A patent/PL449564A1/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL235822B1 (en) * | 2018-08-24 | 2020-11-02 | Univ Medyczny W Lublinie | Cryogel bone scaffold based on chitosan and calcium phosphate bioceramics as well as method of producing it |
| PL242079B1 (en) * | 2020-10-29 | 2023-01-16 | Politechnika Poznańska | Titanium material for an implant and method for its production |
Non-Patent Citations (3)
| Title |
|---|
| NIH; Yue Li et al. "Zeolites: A series of promising biomaterials in bone tissue engineering" Front. Bioeng. Biotechnol., 17 November 2022, Sec. Biomaterials, Volume 10 - 2022 | https://doi.org/10.3389/fbioe.2022.1066552 * |
| ScienceDirect; M. Sandomierski et al."Chitosan - zeolite scaffold as a potential biomaterial in the controlled release of drugs for osteoporosis", International Journal of Biological Macromolecules, Volume 223, Part A, 31 December 2022, Pages 812-820 * |
| tandfonline.com; M. Saheban et al."Effect of zeolite on the corrosion behavior, biocompatibility and antibacterial activity of porous magnesium/zeolite composite scaffolds", Materials Technology Advanced Performance Materials, Volume 34, 2019 - Issue 5, https://doi.org/10.1080/10667857.2018.1549803 * |
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