PL450027A1 - Wielospecyficzne przeciwciało 2A3, cząsteczka kwasu nukleinowego kodująca przeciwciało, wektor zawierający cząsteczkę kwasu nukleinowego, konstrukt zawierający CAR z przeciwciałem oraz ich zastosowanie w terapii CAR-T do leczenia nowotworów litych - Google Patents

Wielospecyficzne przeciwciało 2A3, cząsteczka kwasu nukleinowego kodująca przeciwciało, wektor zawierający cząsteczkę kwasu nukleinowego, konstrukt zawierający CAR z przeciwciałem oraz ich zastosowanie w terapii CAR-T do leczenia nowotworów litych

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Publication number
PL450027A1
PL450027A1 PL450027A PL45002724A PL450027A1 PL 450027 A1 PL450027 A1 PL 450027A1 PL 450027 A PL450027 A PL 450027A PL 45002724 A PL45002724 A PL 45002724A PL 450027 A1 PL450027 A1 PL 450027A1
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Poland
Prior art keywords
antibody
nucleic acid
acid molecule
car
therapy
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PL450027A
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English (en)
Inventor
Iga JANCEWICZ
Paweł Wiśniewski
Radosław Zagożdżon
Brygida BARAN
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4Cell Therapies Spółka Akcyjna
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Application filed by 4Cell Therapies Spółka Akcyjna filed Critical 4Cell Therapies Spółka Akcyjna
Priority to PL450027A priority Critical patent/PL450027A1/pl
Priority to PCT/PL2025/050077 priority patent/WO2026084605A1/en
Publication of PL450027A1 publication Critical patent/PL450027A1/pl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00118—Cancer antigens from embryonic or fetal origin
    • A61K39/001182—Carcinoembryonic antigen [CEA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5156—Animal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Developmental Biology & Embryology (AREA)
  • Mycology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Przedmiotem zgłoszenia jest przeciwciało 2A3 charakteryzujące się tym, że wykazuje wielospecyficzność wobec białek z rodziny CEACAM wybranych z grupy obejmującej CEACAM1, CEACAM3, CEACAM5, CEACAM6. Ponadto przedmiotem zgłoszenia jest cząsteczka kwasu nukleinowego kodująca przeciwciało określone w wynalazku, wektor zawierający wymienioną cząsteczkę kwasu nukleinowego oraz konstrukt CAR z wymienionym przeciwciałem. Kolejnym przedmiotem zgłoszenia jest przeciwciało 2A3 do zastosowania w terapii CAR-T do leczenia nowotworów wykazujących nadekspresję białka wybranego spośród CEACAM1, CEACAM3, CEACAM5, CEACAM6 albo jednocześnie wszystkich wymienionych.
PL450027A 2024-10-14 2024-10-14 Wielospecyficzne przeciwciało 2A3, cząsteczka kwasu nukleinowego kodująca przeciwciało, wektor zawierający cząsteczkę kwasu nukleinowego, konstrukt zawierający CAR z przeciwciałem oraz ich zastosowanie w terapii CAR-T do leczenia nowotworów litych PL450027A1 (pl)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL450027A PL450027A1 (pl) 2024-10-14 2024-10-14 Wielospecyficzne przeciwciało 2A3, cząsteczka kwasu nukleinowego kodująca przeciwciało, wektor zawierający cząsteczkę kwasu nukleinowego, konstrukt zawierający CAR z przeciwciałem oraz ich zastosowanie w terapii CAR-T do leczenia nowotworów litych
PCT/PL2025/050077 WO2026084605A1 (en) 2024-10-14 2025-10-13 Multispecific 2a3 antibody, nucleic acid molecule encoding the antibody, vector comprising the nucleic acid molecule, construct comprising a car with the antibody, and their use in car-t cell therapy for treating solid tumors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL450027A PL450027A1 (pl) 2024-10-14 2024-10-14 Wielospecyficzne przeciwciało 2A3, cząsteczka kwasu nukleinowego kodująca przeciwciało, wektor zawierający cząsteczkę kwasu nukleinowego, konstrukt zawierający CAR z przeciwciałem oraz ich zastosowanie w terapii CAR-T do leczenia nowotworów litych

Publications (1)

Publication Number Publication Date
PL450027A1 true PL450027A1 (pl) 2026-04-20

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PL450027A PL450027A1 (pl) 2024-10-14 2024-10-14 Wielospecyficzne przeciwciało 2A3, cząsteczka kwasu nukleinowego kodująca przeciwciało, wektor zawierający cząsteczkę kwasu nukleinowego, konstrukt zawierający CAR z przeciwciałem oraz ich zastosowanie w terapii CAR-T do leczenia nowotworów litych

Country Status (2)

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PL (1) PL450027A1 (pl)
WO (1) WO2026084605A1 (pl)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012040824A1 (en) * 2010-10-01 2012-04-05 National Research Council Of Canada Anti-ceacam6 antibodies and uses thereof
WO2021059075A1 (en) * 2019-09-27 2021-04-01 Janssen Biotech, Inc. Anti-ceacam antibodies and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012040824A1 (en) * 2010-10-01 2012-04-05 National Research Council Of Canada Anti-ceacam6 antibodies and uses thereof
WO2021059075A1 (en) * 2019-09-27 2021-04-01 Janssen Biotech, Inc. Anti-ceacam antibodies and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JANCEWICZ I. ET AL.: "Cancer Immunol Immunother. 2024 Jan 27;73(2): 30", NEW CEACAM-TARGETING 2A3 SINGLE-DOMAIN ANTIBODY-BASED CHIMERIC ANTIGEN RECEPTOR T-CELLS PRODUCE ANTICANCER EFFECTS IN VITRO AND IN VIVO. *

Also Published As

Publication number Publication date
WO2026084605A1 (en) 2026-04-23

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