PL50925B1 - - Google Patents

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Info

Publication number: PL50925B1
Authority: PL; Poland
Prior art keywords: cholecalciferol; dehydrocholesterol; benzene; complex; mixture
Prior art date: 1964-12-19

Application number

PL106698A

Other languages

English (en)

Polish (pl)

Inventor

Henryk Salwa mgr

Romana Jaworska mgr

Zofia Bury mgr

Wieslaw Lewenstein mgr

Vaedtke inz.Jacek

Anna Czarnocka mgr

JaninaJedrzejuk

Original Assignee

Instytut Farmaceutyczny

Filing date

1964-12-19

Publication date

1966-02-25

1964-12-19 Application filed by Instytut Farmaceutyczny filed Critical Instytut Farmaceutyczny

1965-12-17 Priority to SE16404/65A priority Critical patent/SE318873B/xx

1965-12-17 Priority to DE19651493229 priority patent/DE1493229B1/de

1965-12-17 Priority to US514649A priority patent/US3367950A/en

1965-12-17 Priority to NL6516485A priority patent/NL6516485A/xx

1965-12-17 Priority to FR42720A priority patent/FR1481061A/fr

1965-12-20 Priority to GB53929/65A priority patent/GB1081725A/en

1965-12-20 Priority to CH1764865A priority patent/CH467767A/de

1966-02-25 Publication of PL50925B1 publication Critical patent/PL50925B1/pl

Links

QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 63
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 36
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 36
235000005282 vitamin D3 Nutrition 0.000 claims description 36
239000011647 vitamin D3 Substances 0.000 claims description 36
229940021056 vitamin d3 Drugs 0.000 claims description 36
UCTLRSWJYQTBFZ-UHFFFAOYSA-N Dehydrocholesterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCCC(C)C)CCC33)C)C3=CC=C21 UCTLRSWJYQTBFZ-UHFFFAOYSA-N 0.000 claims description 27
239000000203 mixture Substances 0.000 claims description 19
238000000034 method Methods 0.000 claims description 11
150000001875 compounds Chemical class 0.000 claims description 8
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 5
230000001678 irradiating effect Effects 0.000 claims description 2
238000002425 crystallisation Methods 0.000 claims 1
230000008025 crystallization Effects 0.000 claims 1
230000008020 evaporation Effects 0.000 claims 1
238000001704 evaporation Methods 0.000 claims 1
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
YUGCAAVRZWBXEQ-UHFFFAOYSA-N Precholecalciferol Natural products C=1CCC2(C)C(C(C)CCCC(C)C)CCC2C=1C=CC1=C(C)CCC(O)C1 YUGCAAVRZWBXEQ-UHFFFAOYSA-N 0.000 description 6
YUGCAAVRZWBXEQ-WHTXLNIXSA-N previtamin D3 Chemical compound C=1([C@@H]2CC[C@@H]([C@]2(CCC=1)C)[C@H](C)CCCC(C)C)\C=C/C1=C(C)CC[C@H](O)C1 YUGCAAVRZWBXEQ-WHTXLNIXSA-N 0.000 description 6
238000000926 separation method Methods 0.000 description 4
238000000354 decomposition reaction Methods 0.000 description 3
238000001035 drying Methods 0.000 description 3
238000010438 heat treatment Methods 0.000 description 3
239000000126 substance Substances 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
239000003463 adsorbent Substances 0.000 description 2
QYIXCDOBOSTCEI-UHFFFAOYSA-N alpha-cholestanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 QYIXCDOBOSTCEI-UHFFFAOYSA-N 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000001914 filtration Methods 0.000 description 2
239000012535 impurity Substances 0.000 description 2
238000002844 melting Methods 0.000 description 2
230000008018 melting Effects 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
238000011084 recovery Methods 0.000 description 2
239000002904 solvent Substances 0.000 description 2
238000001179 sorption measurement Methods 0.000 description 2
QYIXCDOBOSTCEI-QCYZZNICSA-N (5alpha)-cholestan-3beta-ol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-QCYZZNICSA-N 0.000 description 1
229930182558 Sterol Natural products 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
235000012000 cholesterol Nutrition 0.000 description 1
238000011109 contamination Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
QYIXCDOBOSTCEI-NWKZBHTNSA-N coprostanol Chemical compound C([C@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-NWKZBHTNSA-N 0.000 description 1
230000008021 deposition Effects 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
238000002955 isolation Methods 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
238000006303 photolysis reaction Methods 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
239000000047 product Substances 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
238000010992 reflux Methods 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
238000002798 spectrophotometry method Methods 0.000 description 1
235000003702 sterols Nutrition 0.000 description 1
150000003432 sterols Chemical class 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
-1 vitamin D3 Chemical compound 0.000 description 1
238000005406 washing Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

PL106698A 1964-12-19 1964-12-19 PL50925B1 (de)

Priority Applications (7)

Application Number	Priority Date	Filing Date	Title
SE16404/65A SE318873B (de)	1964-12-19	1965-12-17
DE19651493229 DE1493229B1 (de)	1964-12-19	1965-12-17	Verfahren zur Gewinnung von Cholecalciferol
US514649A US3367950A (en)	1964-12-19	1965-12-17	Process for the isolation of cholecalciferol from a mixture obtained on irradiation of 7-dehydrocholesterol
NL6516485A NL6516485A (de)	1964-12-19	1965-12-17
FR42720A FR1481061A (fr)	1964-12-19	1965-12-17	Procédé d'extraction du cholécalciférol à partir d'un mélange obtenu par irradiation du déhydro-7 cholestérol
GB53929/65A GB1081725A (en)	1964-12-19	1965-12-20	Process for the isolation of cholecalciferol
CH1764865A CH467767A (de)	1964-12-19	1965-12-20	Verfahren zur Gewinnung von Cholecalciferol

Publications (1)

Publication Number	Publication Date
PL50925B1 true PL50925B1 (de)	1966-02-25

Family

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