PT100492A - Agentes farmaceuticos para aplicacao transcutanea contendo derivados de ergolina - Google Patents

Agentes farmaceuticos para aplicacao transcutanea contendo derivados de ergolina

Info

Publication number: PT100492A
Authority: PT; Portugal
Prior art keywords: pharmaceutical agents; application containing; ergoline derivatives; transcutaneous application; containing ergoline
Prior art date: 1991-05-18

Application number

PT100492A

Other languages

English (en)

Other versions

PT100492B (pt

Inventor

Jutta Riedll

Clemens Gunther

Ralph Lipp

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-18

Filing date

1992-05-15

Publication date

1993-10-29

1992-05-15 Application filed by Schering Ag filed Critical Schering Ag

1993-10-29 Publication of PT100492A publication Critical patent/PT100492A/pt

1999-06-30 Publication of PT100492B publication Critical patent/PT100492B/pt

Links

AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title abstract 3
239000008177 pharmaceutical agent Substances 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
230000035515 penetration Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT100492A 1991-05-18 1992-05-15 Agentes farmaceuticos para aplicacao transcutanea contendo derivados de ergolina PT100492B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4116912A DE4116912A1 (de)	1991-05-18	1991-05-18	Mittel zur transdermalen applikation enthaltend ergolin-derivate

Publications (2)

Publication Number	Publication Date
PT100492A true PT100492A (pt)	1993-10-29
PT100492B PT100492B (pt)	1999-06-30

Family

ID=6432298

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT100492A PT100492B (pt)	1991-05-18	1992-05-15	Agentes farmaceuticos para aplicacao transcutanea contendo derivados de ergolina

Country Status (14)

Country	Link
US (1)	US5399355A (pt)
EP (2)	EP0538433B1 (pt)
JP (1)	JP3725153B2 (pt)
AT (2)	ATE264679T1 (pt)
AU (1)	AU1637792A (pt)
CA (1)	CA2068970C (pt)
DE (3)	DE4116912A1 (pt)
DK (1)	DK1027889T3 (pt)
ES (2)	ES2251936T3 (pt)
HU (1)	HUT64227A (pt)
IE (1)	IE921586A1 (pt)
NO (1)	NO930148D0 (pt)
PT (1)	PT100492B (pt)
WO (1)	WO1992020339A1 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE59409873D1 (de) *	1993-04-20	2001-10-25	Hexal Ag	Wirkstoffpflaster
DE19626621A1 (de) *	1996-07-02	1998-01-08	Hexal Ag	Pflaster zur transdermalen Anwendung von Pergolid
US5837289A (en) *	1996-07-23	1998-11-17	Grasela; John C.	Transdermal delivery of medications using a combination of penetration enhancers
US5900249A (en) *	1998-02-09	1999-05-04	Smith; David J.	Multicomponent pain relief topical medication
FR2793890B1 (fr)	1999-05-19	2002-01-18	France Telecom	Boitier d'acces a une ou plusieurs fibres optiques dans un cable tendu
DE10033853A1 (de) *	2000-07-12	2002-01-31	Hexal Ag	Transdermales therapeutisches System mit hochdispersem Siliziumdioxid
DE10053397A1 (de) *	2000-10-20	2002-05-02	Schering Ag	Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
US20070243240A9 (en) *	2000-08-24	2007-10-18	Fred Windt-Hanke	Transdermal therapeutic system
DE10043321B4 (de) *	2000-08-24	2005-07-28	Neurobiotec Gmbh	Verwendung eines transdermalen therapeutischen Systems zur Behandlung der Parkinsonschen Krankheit, zur Behandlung und Prävention des prämenstruellen Syndroms und zur Lactationshemmung
DE10064453A1 (de) *	2000-12-16	2002-07-04	Schering Ag	Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
EP1390383B1 (en) *	2001-05-11	2012-02-29	Isis Pharmaceuticals, Inc.	Antisense permeation enhancers
DE10137082A1 (de)	2001-07-28	2003-02-13	Hexal Ag	Matrixkontrolliertes transdermales therapeutisches System zur Anwendung von Pramiprexol und Ropinirol
DE10137162A1 (de) *	2001-07-30	2003-02-20	Hexal Ag	Matrixkontrolliertes transdermales therapeutisches System zur Anwendung von Pramiprexol und Ropinirol
US7241456B2 (en) *	2002-10-25	2007-07-10	Australian Importers Ltd.	Formulations for topical delivery of bioactive substances and methods for their use
US8741332B2 (en) *	2004-06-07	2014-06-03	Nuvo Research Inc.	Compositions and methods for dermally treating neuropathic pain
US8907153B2 (en)	2004-06-07	2014-12-09	Nuvo Research Inc.	Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same
US8741333B2 (en) *	2004-06-07	2014-06-03	Nuvo Research Inc.	Compositions and methods for treating dermatitis or psoriasis
US20070196452A1 (en) *	2004-06-07	2007-08-23	Jie Zhang	Flux-enabling compositions and methods for dermal delivery of drugs
US20070196453A1 (en) *	2004-06-07	2007-08-23	Jie Zhang	Two or more non-volatile solvent-containing compositions and methods for dermal delivery of drugs
US20070196457A1 (en) *	2004-06-07	2007-08-23	Jie Zhang	Two or more volatile solvent-containing compositions and methods for dermal delivery of drugs
US20070280972A1 (en) *	2006-04-25	2007-12-06	Zars, Inc.	Adhesive solid gel-forming formulations for dermal drug delivery
DE102006048130A1 (de) *	2006-10-06	2008-04-10	Axxonis Pharma Ag	Transdermales therapeutisches System mit zweiphasigem Freisetzungsprofil
US20090239894A1 (en) *	2008-03-20	2009-09-24	Bjorn Schurad	Stabilized aqueous solutions of ergoline compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3333240A1 (de) *	1983-09-12	1985-03-28	Schering AG, 1000 Berlin und 4709 Bergkamen	Mittel zur transdermalen applikation von arzneimittelwirkstoffen
HU197847B (en) *	1984-03-01	1989-06-28	Sandoz Ag	Process for producing therapeutical preparations suitable for transdermatic treating
US4883669A (en) *	1985-02-25	1989-11-28	Rutgers, The State University Of New Jersey	Transdermal absorption dosage unit for estradiol and other estrogenic steroids and process for administration
EP0208417A3 (en) *	1985-06-12	1989-09-06	SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu	Use of 1-(8-alpha-ergolinyl)-3,3-diethyl urea derivatives in the treatment of endometritis
US4835159A (en) *	1987-05-11	1989-05-30	Eli Lilly And Company	Ergoline esters useful as serotonin antagonists
US4782063A (en) *	1987-05-11	1988-11-01	Eli Lilly And Company	Ergoline esters useful as serotonin antagonists
US5252335A (en) *	1989-07-12	1993-10-12	Cygnus Therapeutic Systems	Transdermal administration of lisuride
US5229129A (en) *	1989-07-12	1993-07-20	Cygnus Therapeutic Systems	Transdermal administration of lisuride

1991
- 1991-05-18 DE DE4116912A patent/DE4116912A1/de not_active Ceased
1992
- 1992-05-14 DE DE59210003T patent/DE59210003D1/de not_active Expired - Lifetime
- 1992-05-14 DK DK00250117T patent/DK1027889T3/da active
- 1992-05-14 DE DE59209996T patent/DE59209996D1/de not_active Expired - Fee Related
- 1992-05-14 EP EP92909703A patent/EP0538433B1/de not_active Expired - Lifetime
- 1992-05-14 ES ES00250117T patent/ES2251936T3/es not_active Expired - Lifetime
- 1992-05-14 HU HU9300125A patent/HUT64227A/hu unknown
- 1992-05-14 WO PCT/DE1992/000400 patent/WO1992020339A1/de not_active Ceased
- 1992-05-14 JP JP50914192A patent/JP3725153B2/ja not_active Expired - Fee Related
- 1992-05-14 EP EP00250117A patent/EP1027889B8/de not_active Expired - Lifetime
- 1992-05-14 AT AT92909703T patent/ATE264679T1/de not_active IP Right Cessation
- 1992-05-14 AT AT00250117T patent/ATE311862T1/de not_active IP Right Cessation
- 1992-05-14 ES ES92909703T patent/ES2219639T3/es not_active Expired - Lifetime
- 1992-05-15 PT PT100492A patent/PT100492B/pt not_active IP Right Cessation
- 1992-05-18 AU AU16377/92A patent/AU1637792A/en not_active Abandoned
- 1992-05-19 CA CA002068970A patent/CA2068970C/en not_active Expired - Fee Related
- 1992-07-01 IE IE158692A patent/IE921586A1/en not_active Application Discontinuation
1993
- 1993-01-15 NO NO930148A patent/NO930148D0/no unknown
- 1993-03-30 US US08/040,393 patent/US5399355A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0538433A1 (de)	1993-04-28
EP1027889A3 (de)	2001-01-24
ES2251936T3 (es)	2006-05-16
DE59209996D1 (de)	2004-05-27
HUT64227A (en)	1993-12-28
PT100492B (pt)	1999-06-30
JPH06500126A (ja)	1994-01-06
EP1027889A2 (de)	2000-08-16
DE59210003D1 (de)	2006-01-12
IE921586A1 (en)	1992-11-18
US5399355A (en)	1995-03-21
DE4116912A1 (de)	1992-11-26
CA2068970A1 (en)	1993-11-20
ATE311862T1 (de)	2005-12-15
ATE264679T1 (de)	2004-05-15
NO930148L (no)	1993-01-15
DK1027889T3 (da)	2006-04-18
JP3725153B2 (ja)	2005-12-07
NO930148D0 (no)	1993-01-15
HU9300125D0 (en)	1993-04-28
WO1992020339A1 (de)	1992-11-26
AU1637792A (en)	1992-11-19
CA2068970C (en)	2005-09-27
ES2219639T3 (es)	2004-12-01
EP1027889B8 (de)	2006-07-05
EP1027889B1 (de)	2005-12-07
EP0538433B1 (de)	2004-04-21

Legal Events

Date	Code	Title	Description
1993-10-29	BB1A	Laying open of patent application	Effective date: 19930310
1999-06-30	FG3A	Patent granted, date of granting	Effective date: 19990315
2007-07-06	PC4A	Transfer of assignment	Owner name: NEUROBIOTEC GMBH, SOCIEDADE ALEMA, DE Effective date: 20070626 Owner name: NEUROBIOTEC PHARMA AG, SOCIEDADE ALEMA, DE Effective date: 20070626
2007-07-06	PD4A	Change of proprietorship	Owner name: AXXONIS PHARMA AG, DE Effective date: 20070626
2011-09-26	MM4A	Annulment/lapse due to non-payment of fees, searched and examined patent	Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20110915

Publication	Publication Date	Title
ATE264679T1 (de)	2004-05-15	Mittel zur transdermalen applikation enthaltend ergolin-derivate
NO900151D0 (no)	1990-01-11	Innretning for avgivelse av midler med en gunstig virkning
NO953837D0 (no)	1995-09-28	Heterocykliske derivater som inhibitorer for blodplateaggregering
ATE269290T1 (de)	2004-07-15	Benzoylderivate
EP0359499A3 (en)	1990-06-20	Fluoro substituted benzocycloheptapyridine compounds, compositions and methods of use as antihistaminic compounds
DK0511541T3 (pt)	1997-01-20
ES2055406T3 (es)	1994-08-16	Composicion para el tratamiento de la inflamacion.
AR241082A2 (es)	1991-10-31	Nuevos derivados de pirazol utiles como agentes herbicidas, las composiciones herbicidas que los contienen y los procedimientos para producir estos derivados de pirazol".
ATE141794T1 (de)	1996-09-15	Stimulierung von wundheilung mit 15-keto- prostaglandinverbindungen
AU611336B2 (en)	1991-06-06	Dispensing devices powered by lyotropic liquid crystals
NO923200D0 (no)	1992-08-14	Piperidin-derivater
ES2044405T3 (es)	1994-01-01	Un procedimiento para preparar una composicion de carboplatino.
AU665212B2 (en)	1995-12-21	1,3,5-triazine-2,4,6-tris-alkylaminocarboxylic acid aminoesters, biocidal agents containing such esters, and methods of preparing them
DE3165050D1 (en)	1984-08-30	Salt of furosemide or piretanide as acid component and penbutolol as base component and pharmaceutical composition containing both of the said components
ES2144995T3 (es)	2000-07-01	Preparacion de derivados de indol.
IL69203A (en)	1986-03-31	Stable,ready-to-use aqueous formulations of vinca dimer alkaloid salts for intravenous injections
GR3004848T3 (pt)	1993-04-28
GB8921072D0 (en)	1989-11-01	Preservative for ophthalmic solutions
ATE17943T1 (de)	1986-02-15	Als schaedlingsbekaempfungsmittel wirksame pyrimidin derivate.
GB8813670D0 (en)	1988-07-13	Veterinary composition
NO179072C (no)	1996-07-31	Glutarsyrederivater, samt fremstilling derav
RO80902A2 (ro)	1983-02-15	Sursa de curent constant pentru alimentarea unui laser
DK0574857T3 (da)	1998-05-04	Polycycliske 31668P- og 31668U-forbindelser, fremgangsmåder til deres fremstilling samt deres anvendelse som antibiotiske eller antitumorale lægemidler