PT101422A - Formulacoes lipossomicas contendo vidarabina e/ou derivados, com indice terapeutico elevado e processo para a sua preparacao - Google Patents

Formulacoes lipossomicas contendo vidarabina e/ou derivados, com indice terapeutico elevado e processo para a sua preparacao

Info

Publication number: PT101422A
Authority: PT; Portugal
Prior art keywords: derivatives; preparation; formulations containing; therapeutic index; liposomal formulations
Prior art date: 1993-12-06

Application number

PT101422A

Other languages

English (en)

Other versions

PT101422B (pt

Inventor

Maria Eugenia Meirinhos D Cruz

Carlos Mauricio Goncal Barbosa

Luis Filipe Diniz Cab Caldeira

Original Assignee

Ineti Inst Biotec Q F E Tecnol

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-06

Filing date

1993-12-06

Publication date

1995-06-30

1993-12-06 Application filed by Ineti Inst Biotec Q F E Tecnol filed Critical Ineti Inst Biotec Q F E Tecnol

1993-12-06 Priority to PT101422A priority Critical patent/PT101422B/pt

1994-12-06 Priority to EP95903468A priority patent/EP0731703B1/en

1994-12-06 Priority to DE69433137T priority patent/DE69433137T2/de

1994-12-06 Priority to PCT/PT1994/000013 priority patent/WO1995015762A1/en

1995-06-30 Publication of PT101422A publication Critical patent/PT101422A/pt

1997-06-30 Publication of PT101422B publication Critical patent/PT101422B/pt

Links

OIRDTQYFTABQOQ-UHTZMRCNSA-N Vidarabine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O OIRDTQYFTABQOQ-UHTZMRCNSA-N 0.000 title 1
239000000203 mixture Substances 0.000 title 1
231100001274 therapeutic index Toxicity 0.000 title 1
229960003636 vidarabine Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Dispersion Chemistry (AREA)
Molecular Biology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PT101422A 1993-12-06 1993-12-06 Formulacoes lipossomicas contendo vidarabina e/ou derivados, com indice terapeutico elevado e processo para a sua preparacao PT101422B (pt)

Priority Applications (4)

Application Number	Priority Date	Filing Date	Title
PT101422A PT101422B (pt)	1993-12-06	1993-12-06	Formulacoes lipossomicas contendo vidarabina e/ou derivados, com indice terapeutico elevado e processo para a sua preparacao
EP95903468A EP0731703B1 (en)	1993-12-06	1994-12-06	Liposomal formulations containing vidarabine or its derivatives
DE69433137T DE69433137T2 (de)	1993-12-06	1994-12-06	Liposomformulierungen enthaltend vidarabin oder seine derivate
PCT/PT1994/000013 WO1995015762A1 (en)	1993-12-06	1994-12-06	Liposomal formulations containing vidarabine or its derivatives

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PT101422A PT101422B (pt)	1993-12-06	1993-12-06	Formulacoes lipossomicas contendo vidarabina e/ou derivados, com indice terapeutico elevado e processo para a sua preparacao

Publications (2)

Publication Number	Publication Date
PT101422A true PT101422A (pt)	1995-06-30
PT101422B PT101422B (pt)	1997-06-30

Family

ID=20085352

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT101422A PT101422B (pt)	1993-12-06	1993-12-06	Formulacoes lipossomicas contendo vidarabina e/ou derivados, com indice terapeutico elevado e processo para a sua preparacao

Country Status (4)

Country	Link
EP (1)	EP0731703B1 (pt)
DE (1)	DE69433137T2 (pt)
PT (1)	PT101422B (pt)
WO (1)	WO1995015762A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2387886T3 (es) *	2001-11-13	2012-10-03	Celator Pharmaceuticals, Inc.	Composiciones que transportan lípidos con una mejor estabilidad sanguínea
AU2002340670A1 (en) *	2001-11-13	2003-05-26	Celator Technologies, Inc.	Lipid carrier compositions and methods for improved drug retention
RU2417075C1 (ru) *	2009-11-30	2011-04-27	Государственное образовательное учреждение высшего профессионального образования "Восточно-Сибирский государственный технологический университет"	Способ получения липосомального средства, обладающего ранозаживляющим действием
US9603799B2 (en) *	2013-03-15	2017-03-28	Htd Biosystems Inc.	Liposomal vaccine adjuvants and methods of making and using same
CN105232571A (zh) *	2015-09-28	2016-01-13	海南中化联合制药工业股份有限公司	一种单磷酸阿糖腺苷药物组合物
RS65378B1 (sr)	2017-03-23	2024-04-30	Lipid Systems Sp Z O O	Visokoefikasna inkapsulacija hidrofilnih jedinjenja u unilamelarne lipozome
US11980636B2 (en)	2020-11-18	2024-05-14	Jazz Pharmaceuticals Ireland Limited	Treatment of hematological disorders
CN113171347B (zh) *	2021-04-06	2022-11-29	海南锦瑞制药有限公司	注射用单磷酸阿糖腺苷冻干粉针剂的制备方法
CN113173957B (zh) *	2021-04-28	2023-10-27	海南锦瑞制药有限公司	单磷酸阿糖腺苷的合成方法及应用
CN121015573A (zh) *	2025-10-31	2025-11-28	沈阳天峰生物制药有限公司	一种单磷酸阿糖腺苷脂质体冻干粉针剂及制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH02500360A (ja) *	1986-07-28	1990-02-08	リポソーム　テクノロジー，インコーポレイテッド	粘膜組織上での高い保持力を有するリポソーム
EP0563249B1 (en) *	1990-12-19	1997-04-23	Advanced Magnetics Incorporated	Targeting of therapeutic agents using polysaccharides
CA2091152C (en) *	1993-03-05	2005-05-03	Kirsten Westesen	Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof

1993
- 1993-12-06 PT PT101422A patent/PT101422B/pt not_active IP Right Cessation
1994
- 1994-12-06 EP EP95903468A patent/EP0731703B1/en not_active Expired - Lifetime
- 1994-12-06 DE DE69433137T patent/DE69433137T2/de not_active Expired - Fee Related
- 1994-12-06 WO PCT/PT1994/000013 patent/WO1995015762A1/en not_active Ceased

Also Published As

Publication number	Publication date
DE69433137T2 (de)	2004-07-08
EP0731703A1 (en)	1996-09-18
EP0731703B1 (en)	2003-09-10
PT101422B (pt)	1997-06-30
DE69433137D1 (de)	2003-10-16
WO1995015762A1 (en)	1995-06-15

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Legal Events

Date	Code	Title	Description
1997-06-30	FG3A	Patent granted, date of granting	Effective date: 19970319
2000-12-29	NF3A	Restitutio in integrum	Free format text: 20000929 RESTITUTIO IN INTEGRUM
2002-10-31	NF3A	Restitutio in integrum	Free format text: RESTITUTIO IN INTEGRUMO Effective date: 20020823 Free format text: 20020823 RESTITUTIO IN INTEGRUM
2013-12-13	MM4A	Annulment/lapse due to non-payment of fees, searched and examined patent	Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20131206