PT1098893E - Composto ciclicos uteis n tratamento da dislipidemia, aterosclerose e diabetes, composicoes farmaceuticas e processo de preparacao - Google Patents
Composto ciclicos uteis n tratamento da dislipidemia, aterosclerose e diabetes, composicoes farmaceuticas e processo de preparacaoInfo
- Publication number
- PT1098893E PT1098893E PT99934643T PT99934643T PT1098893E PT 1098893 E PT1098893 E PT 1098893E PT 99934643 T PT99934643 T PT 99934643T PT 99934643 T PT99934643 T PT 99934643T PT 1098893 E PT1098893 E PT 1098893E
- Authority
- PT
- Portugal
- Prior art keywords
- compositions
- useful
- aterosclerosis
- dislipidemia
- cyclical
- Prior art date
Links
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 150000001923 cyclic compounds Chemical class 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyrane Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9809164A FR2781222A1 (fr) | 1998-07-17 | 1998-07-17 | Composes cycliques utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procede de preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1098893E true PT1098893E (pt) | 2003-08-29 |
Family
ID=9528730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99934643T PT1098893E (pt) | 1998-07-17 | 1999-07-09 | Composto ciclicos uteis n tratamento da dislipidemia, aterosclerose e diabetes, composicoes farmaceuticas e processo de preparacao |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6528538B1 (pt) |
| EP (1) | EP1098893B1 (pt) |
| JP (1) | JP2002520407A (pt) |
| KR (1) | KR20010070966A (pt) |
| CN (1) | CN1309655A (pt) |
| AT (1) | ATE235485T1 (pt) |
| AU (1) | AU753287B2 (pt) |
| BR (1) | BR9912138A (pt) |
| CA (1) | CA2337481A1 (pt) |
| DE (1) | DE69906303T2 (pt) |
| DK (1) | DK1098893T3 (pt) |
| ES (1) | ES2192853T3 (pt) |
| FR (1) | FR2781222A1 (pt) |
| HK (1) | HK1039615A1 (pt) |
| HU (1) | HUP0103411A3 (pt) |
| ID (1) | ID27854A (pt) |
| NO (1) | NO20010266L (pt) |
| PL (1) | PL345397A1 (pt) |
| PT (1) | PT1098893E (pt) |
| SK (1) | SK482001A3 (pt) |
| WO (1) | WO2000004011A1 (pt) |
| ZA (1) | ZA200101303B (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| RS20100015A (sr) | 2001-01-26 | 2010-12-31 | Schering Corporation | Kombinacija aktivatora receptora aktiviranog peroksizom- proliferatorom (ppar) fenofibrata sa inhibitorom apsorpcije sterola ezetimibom za vaskularne indikacije |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| PT1355644E (pt) | 2001-01-26 | 2006-11-30 | Schering Corp | Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia |
| TWI311133B (en) | 2001-04-20 | 2009-06-21 | Eisai R&D Man Co Ltd | Carboxylic acid derivativeand the salt thereof |
| EP1452521A4 (en) | 2001-08-17 | 2007-03-14 | Eisai R&D Man Co Ltd | CYCLIC COMPOUND AND AGONIST OF PPAR RECEPTOR |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| EP1429756B1 (en) | 2001-09-21 | 2006-11-22 | Schering Corporation | Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors |
| JP2006508188A (ja) | 2002-11-06 | 2006-03-09 | シェーリング コーポレイション | 脱髄の処置のためのコレステロール吸収インヒビター |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| CN1756756A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
| CN1756755A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
| DE602004016123D1 (de) | 2003-03-07 | 2008-10-09 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
| AU2004233863B2 (en) * | 2003-04-24 | 2010-06-17 | Incyte Holdings Corporation | Aza spiro alkane derivatives as inhibitors of metalloproteases |
| CN1930152A (zh) * | 2004-01-09 | 2007-03-14 | 卡地拉健康护理有限公司 | 用于治疗i.a.肥胖症和糖尿病的1,3－二噁烷衍生物及其类似物 |
| WO2006018855A1 (en) * | 2004-08-20 | 2006-02-23 | Cadila Healthcare Limited | Novel antidiabetic compounds |
| CN100389112C (zh) * | 2004-12-16 | 2008-05-21 | 中国石油化工股份有限公司 | 一类环状缩醛和缩酮化合物及其应用 |
| WO2007099553A2 (en) * | 2006-02-27 | 2007-09-07 | Cadila Healthcare Limited | 1,3-dioxane carboxylic acids |
| KR20090010035A (ko) * | 2006-05-18 | 2009-01-28 | 웰스태트 테러퓨틱스 코포레이션 | 물질대사 장애의 치료용 화합물 |
| US7910108B2 (en) * | 2006-06-05 | 2011-03-22 | Incyte Corporation | Sheddase inhibitors combined with CD30-binding immunotherapeutics for the treatment of CD30 positive diseases |
| WO2016056031A1 (en) | 2014-10-08 | 2016-04-14 | Council Of Scientific & Industrial Research | Novel diol compounds synthesis and its use for formal synthesis of (2r, 3 s)-3-hydroxypipecolic acid |
| US9637575B2 (en) * | 2014-12-31 | 2017-05-02 | W. R. Grace & Co. -Conn. | Catalyst system, olefin polymerization catalyst components comprising at least an internal electron donor compound, and methods of making and using the same |
| CN114867702A (zh) * | 2019-12-13 | 2022-08-05 | 罗地亚经营管理公司 | 苯衍生物的生产 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4032536A (en) | 1976-07-22 | 1977-06-28 | Janssen Pharmaceutica N.V. | (1h-benzimidazol-2-yl)carbamates |
| US5179216A (en) * | 1990-08-16 | 1993-01-12 | American Home Products Corporation | N,n', n'-trisubstituted-5-bisaminomethylene-1,3-dioxane-4,6-dione inhibitors of acyl-coa:cholesterol-acyl transferase |
| TW209868B (pt) * | 1991-04-04 | 1993-07-21 | Yoshitomi Pharmaceutical | |
| DE19637840A1 (de) * | 1996-09-17 | 1998-03-19 | Henkel Kgaa | Verwendung von geminalen Dialkoxyalkansäureestern zur Herstellung von desodorierenden Körperpflegemitteln |
-
1998
- 1998-07-17 FR FR9809164A patent/FR2781222A1/fr not_active Withdrawn
-
1999
- 1999-07-09 US US09/743,759 patent/US6528538B1/en not_active Expired - Fee Related
- 1999-07-09 AT AT99934643T patent/ATE235485T1/de not_active IP Right Cessation
- 1999-07-09 JP JP2000560117A patent/JP2002520407A/ja active Pending
- 1999-07-09 HK HK02100966.8A patent/HK1039615A1/zh unknown
- 1999-07-09 BR BR9912138-7A patent/BR9912138A/pt not_active IP Right Cessation
- 1999-07-09 DK DK99934643T patent/DK1098893T3/da active
- 1999-07-09 PL PL99345397A patent/PL345397A1/xx unknown
- 1999-07-09 WO PCT/EP1999/004831 patent/WO2000004011A1/en not_active Ceased
- 1999-07-09 CN CN99808783A patent/CN1309655A/zh active Pending
- 1999-07-09 CA CA002337481A patent/CA2337481A1/en not_active Abandoned
- 1999-07-09 DE DE69906303T patent/DE69906303T2/de not_active Expired - Fee Related
- 1999-07-09 EP EP99934643A patent/EP1098893B1/en not_active Expired - Lifetime
- 1999-07-09 KR KR1020017000647A patent/KR20010070966A/ko not_active Withdrawn
- 1999-07-09 SK SK48-2001A patent/SK482001A3/sk unknown
- 1999-07-09 PT PT99934643T patent/PT1098893E/pt unknown
- 1999-07-09 AU AU50347/99A patent/AU753287B2/en not_active Ceased
- 1999-07-09 HU HU0103411A patent/HUP0103411A3/hu unknown
- 1999-07-09 ES ES99934643T patent/ES2192853T3/es not_active Expired - Lifetime
- 1999-07-09 ID IDW20010261A patent/ID27854A/id unknown
-
2001
- 2001-01-16 NO NO20010266A patent/NO20010266L/no not_active Application Discontinuation
- 2001-02-15 ZA ZA200101303A patent/ZA200101303B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010070966A (ko) | 2001-07-28 |
| EP1098893B1 (en) | 2003-03-26 |
| ES2192853T3 (es) | 2003-10-16 |
| SK482001A3 (en) | 2001-09-11 |
| US6528538B1 (en) | 2003-03-04 |
| HK1039615A1 (zh) | 2002-05-03 |
| CA2337481A1 (en) | 2000-01-27 |
| ZA200101303B (en) | 2002-05-15 |
| FR2781222A1 (fr) | 2000-01-21 |
| DE69906303D1 (de) | 2003-04-30 |
| NO20010266D0 (no) | 2001-01-16 |
| AU5034799A (en) | 2000-02-07 |
| BR9912138A (pt) | 2001-04-10 |
| PL345397A1 (en) | 2001-12-17 |
| DK1098893T3 (da) | 2003-07-07 |
| HUP0103411A3 (en) | 2002-08-28 |
| AU753287B2 (en) | 2002-10-17 |
| DE69906303T2 (de) | 2003-12-11 |
| JP2002520407A (ja) | 2002-07-09 |
| ATE235485T1 (de) | 2003-04-15 |
| HUP0103411A2 (hu) | 2002-04-29 |
| NO20010266L (no) | 2001-01-16 |
| ID27854A (id) | 2001-04-26 |
| CN1309655A (zh) | 2001-08-22 |
| EP1098893A1 (en) | 2001-05-16 |
| WO2000004011A1 (en) | 2000-01-27 |
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