PT1114819E - Processo para preparação de oxazolidinonas - Google Patents

Processo para preparação de oxazolidinonas Download PDF

Info

Publication number: PT1114819E
Authority: PT; Portugal
Prior art keywords: reacting; substituted; oxazolidinone; oxazolidinones; prepare
Prior art date: 1996-04-11

Application number

PT01302264T

Other languages

English (en)

Portuguese (pt)

Inventor

Bruce A Pearlman

Peter R Manninen

Dana S Toops

David J Houser

Thomas J Fleck

Michael R Barbachyn

William R Perrault

Original Assignee

Pharmacia & Upjohn Co Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-11

Filing date

1997-03-28

Publication date

2008-02-28

1997-03-28 Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc

2008-02-28 Publication of PT1114819E publication Critical patent/PT1114819E/pt

Links

IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title abstract 2
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
-1 5-hydroxymethyl-substituted oxazolidinone Chemical class 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
229910021529 ammonia Inorganic materials 0.000 abstract 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 abstract 1
150000003871 sulfonates Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PT01302264T 1996-04-11 1997-03-28 Processo para preparação de oxazolidinonas PT1114819E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US1549996P	1996-04-11	1996-04-11

Publications (1)

Publication Number	Publication Date
PT1114819E true PT1114819E (pt)	2008-02-28

Family

ID=21771765

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PT01302264T PT1114819E (pt)	1996-04-11	1997-03-28	Processo para preparação de oxazolidinonas
PT97915865T PT892792E (pt)	1996-04-11	1997-03-28	Processo para a preparacao de oxazolidinonas

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PT97915865T PT892792E (pt)	1996-04-11	1997-03-28	Processo para a preparacao de oxazolidinonas

Country Status (24)

Country	Link
US (1)	US5837870A (2)
EP (2)	EP1114819B1 (2)
JP (2)	JP2000508312A (2)
KR (1)	KR100530297B1 (2)
CN (3)	CN1082953C (2)
AT (2)	ATE209193T1 (2)
AU (1)	AU706117B2 (2)
CA (1)	CA2248143C (2)
CZ (2)	CZ200788A3 (2)
DE (2)	DE69738457T2 (2)
DK (2)	DK1114819T3 (2)
ES (2)	ES2298198T3 (2)
HU (1)	HUP0500044A3 (2)
NO (2)	NO311837B1 (2)
NZ (1)	NZ332278A (2)
PL (1)	PL192691B1 (2)
PT (2)	PT1114819E (2)
RU (1)	RU2176643C2 (2)
SG (1)	SG85683A1 (2)
SI (1)	SI0892792T1 (2)
SK (1)	SK284703B6 (2)
TW (1)	TW449593B (2)
WO (1)	WO1997037980A1 (2)
ZA (1)	ZA972983B (2)

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GB9601666D0 (en) *	1996-01-27	1996-03-27	Zeneca Ltd	Chemical compounds
GB9702213D0 (en) *	1996-02-24	1997-03-26	Zeneca Ltd	Chemical compounds
GB9609919D0 (en) *	1996-05-11	1996-07-17	Zeneca Ltd	Chemical compounds
GB9717807D0 (en)	1997-08-22	1997-10-29	Zeneca Ltd	Chemical compounds
GB9717804D0 (en)	1997-08-22	1997-10-29	Zeneca Ltd	Chemical compounds
GB9725244D0 (en)	1997-11-29	1998-01-28	Zeneca Ltd	Chemical compounds
WO1999064417A2 (en)	1998-06-05	1999-12-16	Astrazeneca Ab	Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
EP1008590B1 (en) *	1998-12-07	2006-10-11	Takasago International Corporation	Process for preparing optically active oxazolidinone derivatives
CN1142158C (zh)	1999-02-01	2004-03-17	法玛西雅厄普约翰美国公司	制备环状含硫氟的噁唑烷酮的方法
US6297242B1 (en)	1999-08-12	2001-10-02	Ortho-Mcneil Pharmaceutical, Inc.	N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof
US6608081B2 (en)	1999-08-12	2003-08-19	Ortho-Mcneil Pharmaceutical, Inc.	Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6413981B1 (en)	1999-08-12	2002-07-02	Ortho-Mcneil Pharamceutical, Inc.	Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
GB9928568D0 (en)	1999-12-03	2000-02-02	Zeneca Ltd	Chemical compounds
US6518285B2 (en)	1999-12-21	2003-02-11	Ortho Mcneil Pharmaceutical, Inc.	Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
US6444813B2 (en)	2000-02-02	2002-09-03	Pharmacia & Upjohn Company	Linezolid-crystal form II
AR027261A1 (es) *	2000-02-02	2003-03-19	Upjohn Co	Linezolid forma cristalina ii
MY127336A (en)	2000-03-22	2006-11-30	Upjohn Co	Container for linezolid iv solution
US6514529B2 (en)	2000-03-22	2003-02-04	Pharmacia & Upjohn Company	Oxazolidinone tablet formulation
GB0009803D0 (en) *	2000-04-25	2000-06-07	Astrazeneca Ab	Chemical compounds
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US6288239B1 (en)	2000-09-19	2001-09-11	Board Of Trustees Operating Michigan State University	5-trityloxymethyl-oxazolidinones and process for the preparation thereof
PE20020578A1 (es)	2000-10-10	2002-08-14	Upjohn Co	Una composicion de antibiotico topico para el tratamiento de infecciones oculares
DE60212959T2 (de) *	2001-04-07	2007-02-15	Astrazeneca Ab	Eine sulfonimid-gruppe enthaltende oxazolidinone als antibiotika
AU2002255803B2 (en)	2001-04-20	2008-07-03	Pharmacia And Upjohn Company	Process to prepare oxazolidinones
ES2186550B2 (es) *	2001-06-27	2003-11-16	Vita Lab	Nuevos derivados de oxazolidinonas como antibacterianos.
WO2003106413A2 (en) *	2001-10-18	2003-12-24	Michigan State University	Process for the preparation of oxazolidinones and method of use thereof
BR0307898A (pt) *	2002-02-22	2004-12-07	Pharmacia Corp	Formulações de droga antibiótica oftálmica contendo um composto de ciclodextrina e cloreto de cetil piridìnio
MXPA04008171A (es) *	2002-02-22	2004-11-26	Pharmacia Corp	Formulacion oftalmica con sistema de goma.
PT1673370E (pt)	2003-10-16	2009-11-05	Symed Labs Ltd	Forma cristalina de linezolida
WO2005099353A2 (en)	2004-04-19	2005-10-27	Symed Labs Limited	A novel process for the preparation of linezolid and related compounds
WO2006008754A1 (en)	2004-07-20	2006-01-26	Symed Labs Limited	Novel intermediates for linezolid and related compounds
EP2007740A1 (en) *	2006-04-07	2008-12-31	Pfizer Products Incorporated	Process for preparing linezolid
CN100395270C (zh) *	2006-05-25	2008-06-18	湖北大学	线型聚苯乙烯支载的(4s)-5,5-二取代基噁唑烷酮及其制备方法和用途
EP2033960A3 (en) *	2007-09-04	2009-04-29	Dipharma Francis S.r.l.	Linezolid crystalline hydrate form and linezolid salts
US20090093631A1 (en) *	2007-09-06	2009-04-09	Ben-Zion Dolitzky	Processes for the preparation of a linezolid intermediate, linezolid hydroxide
EP2163547A1 (en)	2008-09-16	2010-03-17	Unión Químico Farmacéutica, S.A. (UQUIFA)	Process for the preparation of an oxazolidinone antibacterial agent and intermediates thereof
JP5561462B2 (ja) *	2009-09-17	2014-07-30	日東化成株式会社	漁網防汚塗料組成物、該組成物を用いて形成される防汚塗膜、該塗膜の形成方法、および該塗膜を表面に有する漁網、漁網用具又は水中構造物
WO2011077310A1 (en) *	2009-12-26	2011-06-30	Alembic Limited	Process for the preparation of linezolid
US20120283434A1 (en)	2010-01-04	2012-11-08	Enantia, S.L.	Process for the preparation of rivaroxaban and intermediates thereof
EP2603506A1 (en)	2010-08-11	2013-06-19	Synthon BV	Process for making linezolid
EP2603505A1 (en)	2010-08-11	2013-06-19	Synthon BV	Process for making linezolid
EP2635589A1 (en)	2010-11-03	2013-09-11	Wockhardt Limited	Process for the preparation of phosphoric acid mono- (l-{4- [(s) -5- (acetylaminomethyl) - 2 - oxo - oxazolidin- 3 - yl]- 2, 6 - difluorophenyl} - 4 -methoxymethylpiperidin- 4 - yl) ester
WO2012094622A2 (en) *	2011-01-07	2012-07-12	The Regents Of The University Of California	Amination of aryl alcohol derivatives
CN102153521B (zh) *	2011-01-31	2012-09-12	宁波市鄞州百特佳医药科技有限公司	一种用于制备利奈唑胺的中间体及其制备方法
WO2012114354A1 (en)	2011-02-24	2012-08-30	Lee Pharma Limited	Anhydrous linezolid crystalline form-ii
CN103391927A (zh)	2011-02-24	2013-11-13	李药业有限公司	利奈唑胺及其新中间体的新制备方法
CN102321042B (zh) *	2011-07-18	2013-12-04	苏州敬业医药化工有限公司	3-取代苯基-5-羟甲基噁唑烷-2-酮的制备方法
CN102311402B (zh) *	2011-07-18	2013-08-21	苏州敬业医药化工有限公司	3-取代苯基-5-羟甲基噁唑烷-2-酮的制备方法
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IN2014DN06213A (2)	2012-01-24	2015-10-23	Jubilant Life Sciences Ltd
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1997
- 1997-03-28 DK DK01302264T patent/DK1114819T3/da active
- 1997-03-28 DK DK97915865T patent/DK0892792T3/da active
- 1997-03-28 ES ES01302264T patent/ES2298198T3/es not_active Expired - Lifetime
- 1997-03-28 ES ES97915865T patent/ES2166073T3/es not_active Expired - Lifetime
- 1997-03-28 SG SG9905133A patent/SG85683A1/en unknown
- 1997-03-28 CN CN97193658A patent/CN1082953C/zh not_active Expired - Fee Related
- 1997-03-28 NZ NZ332278A patent/NZ332278A/xx unknown
- 1997-03-28 WO PCT/US1997/003458 patent/WO1997037980A1/en not_active Ceased
- 1997-03-28 AU AU23182/97A patent/AU706117B2/en not_active Ceased
- 1997-03-28 HU HU0500044A patent/HUP0500044A3/hu unknown
- 1997-03-28 PL PL329295A patent/PL192691B1/pl not_active IP Right Cessation
- 1997-03-28 DE DE69738457T patent/DE69738457T2/de not_active Expired - Fee Related
- 1997-03-28 US US08/828,923 patent/US5837870A/en not_active Expired - Fee Related
- 1997-03-28 EP EP01302264A patent/EP1114819B1/en not_active Expired - Lifetime
- 1997-03-28 CN CNB031594743A patent/CN1319952C/zh not_active Expired - Fee Related
- 1997-03-28 PT PT01302264T patent/PT1114819E/pt unknown
- 1997-03-28 SI SI9730273T patent/SI0892792T1/xx unknown
- 1997-03-28 PT PT97915865T patent/PT892792E/pt unknown
- 1997-03-28 SK SK1336-98A patent/SK284703B6/sk unknown
- 1997-03-28 DE DE69709718T patent/DE69709718T2/de not_active Expired - Fee Related
- 1997-03-28 JP JP9536189A patent/JP2000508312A/ja not_active Ceased
- 1997-03-28 CZ CZ2007-88A patent/CZ200788A3/cs unknown
- 1997-03-28 AT AT97915865T patent/ATE209193T1/de not_active IP Right Cessation
- 1997-03-28 KR KR10-2004-7009934A patent/KR100530297B1/ko not_active Expired - Fee Related
- 1997-03-28 EP EP97915865A patent/EP0892792B1/en not_active Expired - Lifetime
- 1997-03-28 RU RU98120398/04A patent/RU2176643C2/ru not_active IP Right Cessation
- 1997-03-28 AT AT01302264T patent/ATE383347T1/de not_active IP Right Cessation
- 1997-03-28 CZ CZ0287198A patent/CZ298060B6/cs not_active IP Right Cessation
- 1997-03-28 CA CA002248143A patent/CA2248143C/en not_active Expired - Fee Related
- 1997-03-28 CN CNB011330031A patent/CN1167701C/zh not_active Expired - Fee Related
- 1997-04-02 TW TW086104216A patent/TW449593B/zh not_active IP Right Cessation
- 1997-04-08 ZA ZA972983A patent/ZA972983B/xx unknown
1998
- 1998-10-09 NO NO19984737A patent/NO311837B1/no unknown
2001
- 2001-10-26 NO NO20015253A patent/NO312728B1/no unknown
2008
- 2008-03-04 JP JP2008053675A patent/JP2008239621A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
ES2298198T3 (es)	2008-05-16
DK1114819T3 (da)	2008-04-14
JP2000508312A (ja)	2000-07-04
HK1018785A1 (en)	2000-01-07
NZ332278A (en)	2000-05-26
KR100530297B1 (ko)	2005-11-22
CZ298060B6 (cs)	2007-06-06
PL329295A1 (en)	1999-03-15
CN1381454A (zh)	2002-11-27
KR20040066189A (ko)	2004-07-23
JP2008239621A (ja)	2008-10-09
ATE383347T1 (de)	2008-01-15
SG85683A1 (en)	2002-01-15
SK133698A3 (en)	1999-06-11
NO311837B1 (no)	2002-02-04
NO984737L (no)	1998-12-09
EP1114819A1 (en)	2001-07-11
DE69738457T2 (de)	2008-12-24
CN1496983A (zh)	2004-05-19
RU2176643C2 (ru)	2001-12-10
AU2318297A (en)	1997-10-29
EP0892792B1 (en)	2001-11-21
SI0892792T1 (en)	2002-06-30
ZA972983B (en)	1998-10-08
DE69709718D1 (de)	2002-02-21
PT892792E (pt)	2002-05-31
NO984737D0 (no)	1998-10-09
TW449593B (en)	2001-08-11
DE69709718T2 (de)	2002-06-20
CZ287198A3 (cs)	1999-02-17
CN1082953C (zh)	2002-04-17
WO1997037980A1 (en)	1997-10-16
EP1114819B1 (en)	2008-01-09
CN1319952C (zh)	2007-06-06
AU706117B2 (en)	1999-06-10
DE69738457D1 (de)	2008-02-21
HK1061241A1 (en)	2004-09-10
NO312728B1 (no)	2002-06-24
CA2248143C (en)	2008-10-07
CA2248143A1 (en)	1997-10-16
ES2166073T3 (es)	2002-04-01
CN1167701C (zh)	2004-09-22
ATE209193T1 (de)	2001-12-15
HU0500044D0 (en)	2005-03-29
EP0892792A1 (en)	1999-01-27
NO20015253L (no)	1998-12-09
US5837870A (en)	1998-11-17
SK284703B6 (sk)	2005-09-08
HUP0500044A3 (en)	2005-09-28
NO20015253D0 (no)	2001-10-26
CN1215393A (zh)	1999-04-28
CZ200788A3 (cs)	2017-01-25
PL192691B1 (pl)	2006-11-30
DK0892792T3 (da)	2002-04-02

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