PT1303490E - Óxidos de aminas como pró-fármacos de antagonistas dosreceptores nk1, de derivados de 4-fenil-piridina - Google Patents

Óxidos de aminas como pró-fármacos de antagonistas dosreceptores nk1, de derivados de 4-fenil-piridina Download PDF

Info

Publication number: PT1303490E
Authority: PT; Portugal
Prior art keywords: methyl; tolyl; oxy; trifluoromethyl; morpholin
Prior art date: 2000-07-14

Application number

PT01949475T

Other languages

English (en)

Portuguese (pt)

Inventor

Andrew Sleight

Sonia Maria Poli

Patrick Schnider

Torsten Hoffmann

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-14

Filing date

2001-07-09

Publication date

2008-09-04

2001-07-09 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2008-09-04 Publication of PT1303490E publication Critical patent/PT1303490E/pt

Links

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239000003755 preservative agent Substances 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
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230000011514 reflex Effects 0.000 description 1
208000023504 respiratory system disease Diseases 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
238000004007 reversed phase HPLC Methods 0.000 description 1
238000003345 scintillation counting Methods 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
229940079827 sodium hydrogen sulfite Drugs 0.000 description 1
235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
PODWXQQNRWNDGD-UHFFFAOYSA-L sodium thiosulfate pentahydrate Chemical compound O.O.O.O.O.[Na+].[Na+].[O-]S([S-])(=O)=O PODWXQQNRWNDGD-UHFFFAOYSA-L 0.000 description 1
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239000006228 supernatant Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
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LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
WHRNULOCNSKMGB-UHFFFAOYSA-N tetrahydrofuran thf Chemical compound C1CCOC1.C1CCOC1 WHRNULOCNSKMGB-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
230000004797 therapeutic response Effects 0.000 description 1
DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 1
BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 description 1
239000005051 trimethylchlorosilane Substances 0.000 description 1
230000008673 vomiting Effects 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000003643 water by type Substances 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Orthopedic Medicine & Surgery (AREA)
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Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

PT01949475T 2000-07-14 2001-07-09 Óxidos de aminas como pró-fármacos de antagonistas dosreceptores nk1, de derivados de 4-fenil-piridina PT1303490E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP00115287		2000-07-14

Publications (1)

Publication Number	Publication Date
PT1303490E true PT1303490E (pt)	2008-09-04

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PT01949475T PT1303490E (pt)	2000-07-14	2001-07-09	Óxidos de aminas como pró-fármacos de antagonistas dosreceptores nk1, de derivados de 4-fenil-piridina

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US (4)	US6593472B2 (2)
EP (1)	EP1303490B1 (2)
JP (1)	JP3950044B2 (2)
KR (1)	KR100501608B1 (2)
CN (1)	CN1178917C (2)
AR (1)	AR029717A1 (2)
AT (1)	ATE400556T1 (2)
AU (1)	AU7061901A (2)
BR (1)	BRPI0112475B8 (2)
CA (1)	CA2415890C (2)
CY (1)	CY1108557T1 (2)
CZ (1)	CZ303639B6 (2)
DE (1)	DE60134749D1 (2)
DK (1)	DK1303490T3 (2)
EC (1)	ECSP034431A (2)
EG (1)	EG24968A (2)
ES (1)	ES2309075T3 (2)
GT (1)	GT200100137A (2)
HR (1)	HRP20030003B1 (2)
HU (1)	HU230316B1 (2)
IL (2)	IL153834A0 (2)
JO (1)	JO2372B1 (2)
MA (1)	MA26929A1 (2)
ME (1)	ME01311B (2)
MX (1)	MXPA03000366A (2)
MY (1)	MY154976A (2)
NO (1)	NO324700B1 (2)
NZ (1)	NZ523273A (2)
PA (1)	PA8522001A1 (2)
PE (1)	PE20020272A1 (2)
PL (1)	PL205207B1 (2)
PT (1)	PT1303490E (2)
RS (1)	RS50932B (2)
RU (1)	RU2266284C2 (2)
SI (1)	SI1303490T1 (2)
UY (1)	UY26839A1 (2)
WO (1)	WO2002006236A1 (2)
ZA (1)	ZA200210207B (2)

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2001
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- 2001-07-09 KR KR10-2003-7000476A patent/KR100501608B1/ko not_active Expired - Lifetime
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- 2001-07-09 JP JP2002512140A patent/JP3950044B2/ja not_active Expired - Lifetime
- 2001-07-09 IL IL15383401A patent/IL153834A0/xx unknown
- 2001-07-09 AU AU7061901A patent/AU7061901A/xx active Pending
- 2001-07-09 NZ NZ523273A patent/NZ523273A/en not_active IP Right Cessation
- 2001-07-09 WO PCT/EP2001/007850 patent/WO2002006236A1/en not_active Ceased
- 2001-07-09 CZ CZ20030428A patent/CZ303639B6/cs not_active IP Right Cessation
- 2001-07-09 BR BRPI0112475A patent/BRPI0112475B8/pt not_active IP Right Cessation
- 2001-07-09 DK DK01949475T patent/DK1303490T3/da active
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- 2001-07-09 RU RU2003102612/04A patent/RU2266284C2/ru active
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2002
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2003
- 2003-01-07 IL IL153834A patent/IL153834A/en active IP Right Grant
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- 2003-01-13 MA MA26997A patent/MA26929A1/fr unknown
- 2003-01-13 NO NO20030154A patent/NO324700B1/no not_active IP Right Cessation
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Also Published As

Publication number	Publication date
ES2309075T3 (es)	2008-12-16
KR100501608B1 (ko)	2005-07-18
US6897226B2 (en)	2005-05-24
NO20030154D0 (no)	2003-01-13
IL153834A0 (en)	2003-07-31
ZA200210207B (en)	2004-03-17
US6806370B2 (en)	2004-10-19
NZ523273A (en)	2004-08-27
ATE400556T1 (de)	2008-07-15
US6593472B2 (en)	2003-07-15
GT200100137A (es)	2002-05-16
CA2415890A1 (en)	2002-01-24
US20040048901A1 (en)	2004-03-11
US20040014793A1 (en)	2004-01-22
PL365684A1 (en)	2005-01-10
EP1303490B1 (en)	2008-07-09
HU230316B1 (hu)	2016-01-28
WO2002006236A1 (en)	2002-01-24
KR20030015387A (ko)	2003-02-20
NO20030154L (no)	2003-01-13
RS50932B (sr)	2010-08-31
HRP20030003A2 (en)	2003-02-28
JO2372B1 (en)	2006-12-12
PL205207B1 (pl)	2010-03-31
US20030149039A1 (en)	2003-08-07
CY1108557T1 (el)	2014-04-09
BR0112475A (pt)	2003-07-29
EG24968A (en)	2011-03-14
JP3950044B2 (ja)	2007-07-25
CZ303639B6 (cs)	2013-01-23
AR029717A1 (es)	2003-07-10
HUP0301311A2 (hu)	2003-08-28
BRPI0112475B8 (pt)	2021-05-25
EP1303490A1 (en)	2003-04-23
CN1178917C (zh)	2004-12-08
PE20020272A1 (es)	2002-04-16
MA26929A1 (fr)	2004-12-20
HK1058198A1 (en)	2004-05-07
ECSP034431A (es)	2003-03-10
US6747026B2 (en)	2004-06-08
YU603A (sh)	2006-01-16
UY26839A1 (es)	2002-01-31
BR0112475B1 (pt)	2013-10-15
DK1303490T3 (da)	2008-08-25
MXPA03000366A (es)	2003-05-27
ME01311B (me)	2013-12-20
US20020045642A1 (en)	2002-04-18
CN1441782A (zh)	2003-09-10
AU7061901A (en)	2002-01-30
HRP20030003B1 (en)	2011-01-31
SI1303490T1 (sl)	2008-10-31
MY154976A (en)	2015-08-28
CA2415890C (en)	2009-04-07
IL153834A (en)	2008-11-03
NO324700B1 (no)	2007-12-03
PA8522001A1 (es)	2002-04-25
JP2004504301A (ja)	2004-02-12
DE60134749D1 (de)	2008-08-21
RU2266284C2 (ru)	2005-12-20

Publication	Publication Date	Title
PT1303490E (pt)	2008-09-04	Óxidos de aminas como pró-fármacos de antagonistas dosreceptores nk1, de derivados de 4-fenil-piridina
JP3399900B2 (ja)	2003-04-21	４−フェニル−ピリジン誘導体
US6576762B2 (en)	2003-06-10	Heteroaromatic substituted amides with antagonistic activity to neurokinin 1 receptors
AU2001282005A1 (en)	2002-05-02	4-phenyl-pyridine derivatives as neurokinin-1 receptor antagonists
AU2001270619B2 (en)	2006-03-23	N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives
AU2001270619A1 (en)	2002-05-02	N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives
IL185010A (en)	2012-10-31	History of bipyridinyl, pharmaceutical preparations that include them and the process for their preparation