PT1463735E - Imidazo-2,1-b-1,3,4-tiadiazol sulfonamidas - Google Patents

Imidazo-2,1-b-1,3,4-tiadiazol sulfonamidas Download PDF

Info

Publication number: PT1463735E
Authority: PT; Portugal
Prior art keywords: imidazo; formula; sulfonamides; thiadiazole; thiadiazole sulfonamides
Prior art date: 2001-12-14

Application number

PT02784979T

Other languages

English (en)

Inventor

John W Gillard

James B Jaquith

Gerald Villeneuve

Alain Boudreault

Stephen Morris

Jon Durkin

Kimberly Hewitt

Nicholas H Marsh

Original Assignee

Aegera Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-14

Filing date

2002-12-16

Publication date

2009-10-15

2002-12-16 Application filed by Aegera Therapeutics Inc filed Critical Aegera Therapeutics Inc

2009-10-15 Publication of PT1463735E publication Critical patent/PT1463735E/pt

Links

229940124530 sulfonamide Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
210000003169 central nervous system Anatomy 0.000 abstract 1
230000001537 neural effect Effects 0.000 abstract 1
239000004090 neuroprotective agent Substances 0.000 abstract 1
210000001428 peripheral nervous system Anatomy 0.000 abstract 1
0 CC=C(**(C1)=CC(c2ccc(C)cc2)=CN1N)[N+](*)([O-])O Chemical compound CC=C(**(C1)=CC(c2ccc(C)cc2)=CN1N)[N+](*)([O-])O 0.000 description 17

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Virology (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Psychology (AREA)
Psychiatry (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Toxicology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)

PT02784979T 2001-12-14 2002-12-16 Imidazo-2,1-b-1,3,4-tiadiazol sulfonamidas PT1463735E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA002364985A CA2364985A1 (en)	2001-12-14	2001-12-14	Imidazo(2,1-b)thiadiazole sulfonamides

Publications (1)

Publication Number	Publication Date
PT1463735E true PT1463735E (pt)	2009-10-15

Family

ID=4170835

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT02784979T PT1463735E (pt)	2001-12-14	2002-12-16	Imidazo-2,1-b-1,3,4-tiadiazol sulfonamidas

Country Status (11)

Country	Link
US (8)	US7230019B2 (pt)
EP (1)	EP1463735B1 (pt)
JP (2)	JP2005519882A (pt)
AT (1)	ATE439363T1 (pt)
AU (1)	AU2002350333B2 (pt)
CA (1)	CA2364985A1 (pt)
DE (1)	DE60233350D1 (pt)
DK (1)	DK1463735T3 (pt)
ES (1)	ES2329882T3 (pt)
PT (1)	PT1463735E (pt)
WO (1)	WO2003051890A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2364985A1 (en) *	2001-12-14	2003-06-14	John W. Gillard	Imidazo(2,1-b)thiadiazole sulfonamides
CN1835956A (zh) *	2003-06-13	2006-09-20	艾吉拉医疗股份有限公司	酰化和非酰化的咪唑并[2,1－b]－1,3,4,－噻二唑－2－磺酰胺及其用途
CA2527903A1 (en) *	2003-06-13	2004-12-23	Aegera Therapeutics, Inc.	Imidazo[2,1-b]-1,3,4-thiadiazole sulfoxides and sulfones
WO2007034278A2 (en) *	2005-09-19	2007-03-29	Pfizer Products Inc.	Fused imidazole derivatives as c3a receptor antagonists
US20090179638A1 (en) *	2006-02-01	2009-07-16	Aegera Therapeutics Inc.	Assay for identifying inhibitors of neuronal apoptotic pathways
ES2660170T3 (es) *	2007-01-25	2018-03-21	NAIA Metabolic, Inc.	Sensibilizadores a la insulina y métodos de tratamiento
DK2193133T3 (en) *	2007-09-27	2015-10-05	Fundacion Ct Nac Investigaciones Oncologicas Carlos Iii	IMIDAZOLOTHIADIAZOLES USED AS PROTEINKINASE INHIBITORS
AU2010231162B2 (en) *	2009-04-02	2014-12-11	Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii	Imidazo [2, 1-b] [ 1, 3, 4 ] thiadiazole derivatives
US8771324B2 (en)	2011-05-27	2014-07-08	Globus Medical, Inc.	Securing fasteners
SG11201406759YA (en)	2012-04-26	2014-11-27	Bristol Myers Squibb Co	Imidazothiadiazole derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation
KR20150003766A (ko) *	2012-04-26	2015-01-09	브리스톨-마이어스 스큅 컴퍼니	혈소판 응집을 치료하기 위한 프로테아제 활성화 수용체 4 (par4) 억제제로서의 이미다조티아디아졸 및 이미다조피리다진 유도체
ES2640916T3 (es)	2012-04-26	2017-11-07	Bristol-Myers Squibb Company	Derivados de imidazotiadiazol e imidazopirazina como inhibidores del receptor 4 activados por proteasa (PAR4) para tratar agregación plaquetaria
EP3053908B1 (en) *	2013-09-30	2018-12-19	FUJIFILM Corporation	Method for producing alpha-halogenoacetophenon compound, and alpha-bromoacetophenon compound
US9598419B1 (en)	2014-06-24	2017-03-21	Universite De Montreal	Imidazotriazine and imidazodiazine compounds
US9617279B1 (en)	2014-06-24	2017-04-11	Bristol-Myers Squibb Company	Imidazooxadiazole compounds
WO2017184520A1 (en) *	2016-04-18	2017-10-26	Vanderbilt University	Substituted and fused 6-membered protease activated receptor 4 (par-4) antagonists
WO2020045638A1 (ja)	2018-08-30	2020-03-05	日本メジフィジックス株式会社	放射性イミダゾチアジアゾール誘導体化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US52514A (en) *		1866-02-13		Stove-pipe damper
GB1464259A (en) *	1975-10-03	1977-02-09	Pfizer Ltd	Imidazo-thiazole and -thiadiazole sulphonamides and their use as therapeutic agents
US5604202A (en) *	1990-11-13	1997-02-18	Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University	Use of NGF growth factors to treat drug-induced neuropathy
HUP0102935A3 (en)	1998-06-03	2002-01-28	Gpi Nil Holdings Inc Wilmingto	N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres and pharmaceutical compositions containing them
CA2364985A1 (en) *	2001-12-14	2003-06-14	John W. Gillard	Imidazo(2,1-b)thiadiazole sulfonamides
CA2379375A1 (en) *	2002-03-28	2003-09-28	Apotex Inc.	Sulfonamide derivatives of 3-substituted imidazol[1,2-d]-1,2,4-thiadiazoles and 3-substituted-[1,2,4] thiadiazolo[4,5-a] benzimidazole as inhibitors of fibrin cross-linking and transglutaminases

2001
- 2001-12-14 CA CA002364985A patent/CA2364985A1/en not_active Abandoned
2002
- 2002-12-16 US US10/498,548 patent/US7230019B2/en not_active Expired - Fee Related
- 2002-12-16 DE DE60233350T patent/DE60233350D1/de not_active Expired - Lifetime
- 2002-12-16 DK DK02784979T patent/DK1463735T3/da active
- 2002-12-16 ES ES02784979T patent/ES2329882T3/es not_active Expired - Lifetime
- 2002-12-16 EP EP02784979A patent/EP1463735B1/en not_active Expired - Lifetime
- 2002-12-16 JP JP2003552772A patent/JP2005519882A/ja active Pending
- 2002-12-16 AT AT02784979T patent/ATE439363T1/de not_active IP Right Cessation
- 2002-12-16 WO PCT/CA2002/001942 patent/WO2003051890A1/en not_active Ceased
- 2002-12-16 AU AU2002350333A patent/AU2002350333B2/en not_active Ceased
- 2002-12-16 PT PT02784979T patent/PT1463735E/pt unknown
2006
- 2006-04-05 US US11/399,010 patent/US7741349B2/en not_active Expired - Fee Related
- 2006-04-06 US US11/398,806 patent/US20070021416A1/en not_active Abandoned
- 2006-04-06 US US11/399,033 patent/US7772260B2/en not_active Expired - Fee Related
2007
- 2007-05-07 US US11/797,663 patent/US7714003B2/en not_active Expired - Fee Related
- 2007-05-07 US US11/797,665 patent/US7700635B2/en not_active Expired - Fee Related
- 2007-05-07 US US11/797,664 patent/US20070238768A1/en not_active Abandoned
2008
- 2008-04-07 US US12/099,123 patent/US20090042953A1/en not_active Abandoned
2009
- 2009-12-22 JP JP2009291135A patent/JP2010106030A/ja active Pending

Also Published As

Publication number	Publication date
EP1463735B1 (en)	2009-08-12
US7714003B2 (en)	2010-05-11
AU2002350333B2 (en)	2008-08-21
DE60233350D1 (de)	2009-09-24
DK1463735T3 (da)	2009-12-14
US7772260B2 (en)	2010-08-10
CA2364985A1 (en)	2003-06-14
ES2329882T3 (es)	2009-12-02
US7700635B2 (en)	2010-04-20
US7230019B2 (en)	2007-06-12
WO2003051890A1 (en)	2003-06-26
US20090042953A1 (en)	2009-02-12
AU2002350333A1 (en)	2003-06-30
US20070021416A1 (en)	2007-01-25
EP1463735A1 (en)	2004-10-06
US20050069492A1 (en)	2005-03-31
US20070265319A1 (en)	2007-11-15
US20070088059A1 (en)	2007-04-19
US20070021476A1 (en)	2007-01-25
JP2005519882A (ja)	2005-07-07
US20070238766A1 (en)	2007-10-11
JP2010106030A (ja)	2010-05-13
US7741349B2 (en)	2010-06-22
US20070238768A1 (en)	2007-10-11
ATE439363T1 (de)	2009-08-15

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