PT1646607E - Método para a preparação de dexloxiglumida cristalina - Google Patents
Método para a preparação de dexloxiglumida cristalina Download PDFInfo
- Publication number
- PT1646607E PT1646607E PT04743871T PT04743871T PT1646607E PT 1646607 E PT1646607 E PT 1646607E PT 04743871 T PT04743871 T PT 04743871T PT 04743871 T PT04743871 T PT 04743871T PT 1646607 E PT1646607 E PT 1646607E
- Authority
- PT
- Portugal
- Prior art keywords
- preparation
- dexloxiglumide
- crystalline
- crystalline dexloxiglumide
- morphological
- Prior art date
Links
- QNQZBKQEIFTHFZ-GOSISDBHSA-N dexloxiglumide Chemical compound CCCCCN(CCCOC)C(=O)[C@@H](CCC(O)=O)NC(=O)C1=CC=C(Cl)C(Cl)=C1 QNQZBKQEIFTHFZ-GOSISDBHSA-N 0.000 title abstract 2
- 229950010525 dexloxiglumide Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000000877 morphologic effect Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000474A ITTO20030474A1 (it) | 2003-06-23 | 2003-06-23 | Procedimento per la preparazione di dexloxiglumide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1646607E true PT1646607E (pt) | 2010-10-12 |
Family
ID=33524063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT04743871T PT1646607E (pt) | 2003-06-23 | 2004-06-21 | Método para a preparação de dexloxiglumida cristalina |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7662994B2 (pt) |
| EP (1) | EP1646607B1 (pt) |
| JP (1) | JP5197955B2 (pt) |
| AT (1) | ATE478839T1 (pt) |
| AU (1) | AU2004249526B2 (pt) |
| CA (1) | CA2529018C (pt) |
| DE (1) | DE602004028830D1 (pt) |
| DK (1) | DK1646607T3 (pt) |
| ES (1) | ES2351662T3 (pt) |
| IT (1) | ITTO20030474A1 (pt) |
| PT (1) | PT1646607E (pt) |
| WO (1) | WO2004113271A2 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7863330B2 (en) * | 2006-06-14 | 2011-01-04 | Rottapharm S.P.A. | Deloxiglumide and proton pump inhibitor combination in the treatment of gastrointestinal disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1217123B (it) * | 1987-02-05 | 1990-03-14 | Rotta Research Lab | Derivati otticamente attivi dell acido 5 pentilammino 5 oxo pentanoico r ad attivita antagonista della colecistochinina e procedimento per la loro preparazione |
| DE69112917T2 (de) * | 1990-06-15 | 1996-05-15 | Merck & Co Inc | Kristallisationsverfahren zur Verbesserung der Kristallstruktur und -grösse. |
| KR20040094448A (ko) * | 2002-04-02 | 2004-11-09 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 결정 성장에 사용되는 장치 및 방법 |
-
2003
- 2003-06-23 IT IT000474A patent/ITTO20030474A1/it unknown
-
2004
- 2004-06-21 DE DE602004028830T patent/DE602004028830D1/de not_active Expired - Lifetime
- 2004-06-21 WO PCT/IB2004/002208 patent/WO2004113271A2/en not_active Ceased
- 2004-06-21 PT PT04743871T patent/PT1646607E/pt unknown
- 2004-06-21 AU AU2004249526A patent/AU2004249526B2/en not_active Ceased
- 2004-06-21 AT AT04743871T patent/ATE478839T1/de active
- 2004-06-21 JP JP2006516595A patent/JP5197955B2/ja not_active Expired - Fee Related
- 2004-06-21 EP EP04743871A patent/EP1646607B1/en not_active Expired - Lifetime
- 2004-06-21 US US10/562,013 patent/US7662994B2/en not_active Expired - Fee Related
- 2004-06-21 ES ES04743871T patent/ES2351662T3/es not_active Expired - Lifetime
- 2004-06-21 CA CA2529018A patent/CA2529018C/en not_active Expired - Fee Related
- 2004-06-21 DK DK04743871.8T patent/DK1646607T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2351662T3 (es) | 2011-02-09 |
| CA2529018C (en) | 2013-05-28 |
| HK1089750A1 (en) | 2006-12-08 |
| EP1646607A2 (en) | 2006-04-19 |
| AU2004249526A1 (en) | 2004-12-29 |
| US20060154987A1 (en) | 2006-07-13 |
| WO2004113271A3 (en) | 2005-01-27 |
| DK1646607T3 (da) | 2010-11-22 |
| JP5197955B2 (ja) | 2013-05-15 |
| ATE478839T1 (de) | 2010-09-15 |
| AU2004249526B2 (en) | 2011-02-24 |
| DE602004028830D1 (de) | 2010-10-07 |
| US7662994B2 (en) | 2010-02-16 |
| JP2007521253A (ja) | 2007-08-02 |
| WO2004113271A8 (en) | 2005-05-06 |
| EP1646607B1 (en) | 2010-08-25 |
| CA2529018A1 (en) | 2004-12-29 |
| ITTO20030474A1 (it) | 2004-12-24 |
| WO2004113271A2 (en) | 2004-12-29 |
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