PT2041121E - Síntese enantiosselectiva de pirrolidinas substituídas com flavonas - Google Patents
Síntese enantiosselectiva de pirrolidinas substituídas com flavonas Download PDFInfo
- Publication number
- PT2041121E PT2041121E PT06766035T PT06766035T PT2041121E PT 2041121 E PT2041121 E PT 2041121E PT 06766035 T PT06766035 T PT 06766035T PT 06766035 T PT06766035 T PT 06766035T PT 2041121 E PT2041121 E PT 2041121E
- Authority
- PT
- Portugal
- Prior art keywords
- pyrrolidine
- enantioselective synthesis
- substituted flavones
- flavones
- substituted
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- -1 pyrrolidine-substituted flavones Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2006/052294 WO2008007169A1 (en) | 2006-07-07 | 2006-07-07 | An enantioselective synthesis of pyrrolidine-substituted flavones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2041121E true PT2041121E (pt) | 2011-09-12 |
Family
ID=37546592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT06766035T PT2041121E (pt) | 2006-07-07 | 2006-07-07 | Síntese enantiosselectiva de pirrolidinas substituídas com flavonas |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7951961B2 (pt) |
| EP (1) | EP2041121B1 (pt) |
| JP (1) | JP5006396B2 (pt) |
| KR (1) | KR101285957B1 (pt) |
| CN (1) | CN101484445B (pt) |
| AR (1) | AR061964A1 (pt) |
| AT (1) | ATE517892T1 (pt) |
| AU (1) | AU2006346193C1 (pt) |
| BR (1) | BRPI0621851A2 (pt) |
| CA (1) | CA2658215C (pt) |
| DK (1) | DK2041121T3 (pt) |
| IL (1) | IL196298A0 (pt) |
| MX (1) | MX2009000109A (pt) |
| NZ (1) | NZ573841A (pt) |
| PT (1) | PT2041121E (pt) |
| TW (1) | TWI391388B (pt) |
| WO (1) | WO2008007169A1 (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7884127B2 (en) | 2002-07-08 | 2011-02-08 | Pirimal Life Sciences Ltd. | Inhibitors of cyclin dependent kinases and their use |
| LV14179B (lv) * | 2008-12-03 | 2010-08-20 | Ivars Kalvins | 2,2'-ciklopropilidēn-bis-oksazolīnu reģenerēšana |
| TWI461194B (zh) | 2009-05-05 | 2014-11-21 | Piramal Entpr Ltd | 吡咯啶取代黃酮作為輻射致敏劑 |
| WO2012069972A1 (en) | 2010-11-19 | 2012-05-31 | Piramal Life Sciences Limited | A pharmaceutical combination for the treatment of breast cancer |
| KR101264012B1 (ko) * | 2010-12-31 | 2013-05-13 | 주식회사 코리아나화장품 | 플라바논 화합물 및 그 제조방법, 이로부터 제조된 화장료 조성물 |
| TW201242597A (en) | 2011-03-14 | 2012-11-01 | Piramal Life Sciences Ltd | A synergistic pharmaceutical combination for the treatment of pancreatic cancer |
| AU2012274990A1 (en) | 2011-06-24 | 2014-02-06 | Piramal Enterprises Limited | Compounds for the treatment of cancers associated with human papillomavirus |
| EP2802323B1 (en) | 2012-01-13 | 2016-08-10 | Piramal Enterprises Limited | Pyrrolidine-substituted flavone derivatives for prevention or treatment of oral mucositis |
| WO2014018741A1 (en) * | 2012-07-27 | 2014-01-30 | Emory University | Heterocyclic flavone derivatives, compositions, and methods related thereto |
| JP5988305B2 (ja) * | 2013-03-29 | 2016-09-07 | 国立大学法人山口大学 | 光学活性α−ブロモベンゾイル酢酸エステル類の製造方法 |
| CN111053768B (zh) | 2013-07-12 | 2023-12-12 | 皮拉马尔企业有限公司 | 用于治疗黑素瘤的药物组合 |
| CN104725279B (zh) * | 2015-02-12 | 2018-03-02 | 威海迪素制药有限公司 | 一种N‑Boc‑联苯丙氨酸衍生物的制备方法 |
| PL3294743T3 (pl) * | 2015-05-12 | 2020-03-31 | Fmc Corporation | Podstawione arylem związki bicykliczne jako środki chwastobójcze |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849733A (en) * | 1996-05-10 | 1998-12-15 | Bristol-Myers Squibb Co. | 2-thio or 2-oxo flavopiridol analogs |
| EP1280789A1 (en) * | 2000-05-03 | 2003-02-05 | LG Life Sciences Ltd. | Cdk inhibitors having 3-hydroxychromen-4-one structure |
| US6784167B2 (en) * | 2000-09-29 | 2004-08-31 | Bayer Pharmaceuticals Corporation | 17-beta-hydroxysteroid dehydrogenase-II inhibitors |
| TWI331034B (en) * | 2002-07-08 | 2010-10-01 | Piramal Life Sciences Ltd | Inhibitors of cyclin-dependent kinases and their use |
| JP5498782B2 (ja) | 2006-06-21 | 2014-05-21 | ピラマル エンタープライジーズ リミテッド | 増殖性疾患治療用のエナンチオマー的に純粋なフラボン誘導体の調製方法 |
-
2006
- 2006-07-07 AT AT06766035T patent/ATE517892T1/de active
- 2006-07-07 WO PCT/IB2006/052294 patent/WO2008007169A1/en not_active Ceased
- 2006-07-07 US US12/307,645 patent/US7951961B2/en active Active
- 2006-07-07 JP JP2009518985A patent/JP5006396B2/ja not_active Expired - Fee Related
- 2006-07-07 MX MX2009000109A patent/MX2009000109A/es active IP Right Grant
- 2006-07-07 KR KR1020097002349A patent/KR101285957B1/ko not_active Expired - Fee Related
- 2006-07-07 EP EP06766035A patent/EP2041121B1/en not_active Not-in-force
- 2006-07-07 CA CA2658215A patent/CA2658215C/en active Active
- 2006-07-07 BR BRPI0621851-2A patent/BRPI0621851A2/pt not_active IP Right Cessation
- 2006-07-07 CN CN200680055257.0A patent/CN101484445B/zh not_active Expired - Fee Related
- 2006-07-07 DK DK06766035.7T patent/DK2041121T3/da active
- 2006-07-07 AU AU2006346193A patent/AU2006346193C1/en not_active Ceased
- 2006-07-07 NZ NZ573841A patent/NZ573841A/en not_active IP Right Cessation
- 2006-07-07 PT PT06766035T patent/PT2041121E/pt unknown
-
2007
- 2007-06-22 TW TW096122651A patent/TWI391388B/zh not_active IP Right Cessation
- 2007-07-06 AR ARP070103023A patent/AR061964A1/es not_active Application Discontinuation
-
2008
- 2008-12-31 IL IL196298A patent/IL196298A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101484445B (zh) | 2012-09-05 |
| TWI391388B (zh) | 2013-04-01 |
| TW200815413A (en) | 2008-04-01 |
| AR061964A1 (es) | 2008-08-10 |
| JP5006396B2 (ja) | 2012-08-22 |
| ATE517892T1 (de) | 2011-08-15 |
| AU2006346193A2 (en) | 2009-02-12 |
| EP2041121B1 (en) | 2011-07-27 |
| BRPI0621851A2 (pt) | 2013-01-29 |
| MX2009000109A (es) | 2009-03-16 |
| CA2658215C (en) | 2013-08-27 |
| NZ573841A (en) | 2011-11-25 |
| DK2041121T3 (da) | 2011-11-14 |
| JP2009542796A (ja) | 2009-12-03 |
| US20100113803A1 (en) | 2010-05-06 |
| AU2006346193A1 (en) | 2008-01-17 |
| EP2041121A1 (en) | 2009-04-01 |
| US7951961B2 (en) | 2011-05-31 |
| CA2658215A1 (en) | 2008-01-17 |
| CN101484445A (zh) | 2009-07-15 |
| AU2006346193C1 (en) | 2014-02-20 |
| IL196298A0 (en) | 2009-09-22 |
| KR20090033465A (ko) | 2009-04-03 |
| KR101285957B1 (ko) | 2013-07-12 |
| AU2006346193B2 (en) | 2012-11-15 |
| HK1126762A1 (en) | 2009-09-11 |
| WO2008007169A1 (en) | 2008-01-17 |
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