PT2363392T - Derivados de estirilpiridina e sua utilização para ligação e obtenção de imagens de placas amilóides - Google Patents

Derivados de estirilpiridina e sua utilização para ligação e obtenção de imagens de placas amilóides

Info

Publication number: PT2363392T
Authority: PT; Portugal
Prior art keywords: stirylpyridine; derivatives; obtaining images; amyloid; compounds
Prior art date: 2006-03-30

Application number

PT111521241T

Other languages

English (en)

Inventor

F Kung Hank

Kung Mei-Ping

Original Assignee

Univ Pennsylvania

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-03-30

Filing date

2007-03-26

Publication date

2017-06-15

2007-03-26 Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania

2017-06-15 Publication of PT2363392T publication Critical patent/PT2363392T/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Optics & Photonics (AREA)
Epidemiology (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Neurology (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Physical Education & Sports Medicine (AREA)
Emergency Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PT111521241T 2006-03-30 2007-03-26 Derivados de estirilpiridina e sua utilização para ligação e obtenção de imagens de placas amilóides PT2363392T (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US78715606P	2006-03-30	2006-03-30

Publications (1)

Publication Number	Publication Date
PT2363392T true PT2363392T (pt)	2017-06-15

Family

ID=38326579

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PT07753982T PT1999109E (pt)	2006-03-30	2007-03-26	Derivados de estirilpiridina e sua utilização para ligação e obtenção de imagens de placas amilóides
PT111521241T PT2363392T (pt)	2006-03-30	2007-03-26	Derivados de estirilpiridina e sua utilização para ligação e obtenção de imagens de placas amilóides

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PT07753982T PT1999109E (pt)	2006-03-30	2007-03-26	Derivados de estirilpiridina e sua utilização para ligação e obtenção de imagens de placas amilóides

Country Status (35)

Country	Link
US (3)	US7687052B2 (pt)
EP (3)	EP2363391A1 (pt)
JP (1)	JP5290954B2 (pt)
KR (1)	KR101376807B1 (pt)
CN (1)	CN101522624B (pt)
AT (1)	ATE539060T1 (pt)
AU (1)	AU2007243712B2 (pt)
BE (1)	BE2013C044I2 (pt)
BR (1)	BRPI0710225B1 (pt)
CA (1)	CA2644530C (pt)
CR (1)	CR10329A (pt)
CY (3)	CY1113048T1 (pt)
DK (2)	DK2363392T3 (pt)
EA (1)	EA017898B1 (pt)
EC (1)	ECSP088783A (pt)
ES (2)	ES2628882T3 (pt)
FR (1)	FR13C0034I2 (pt)
GT (1)	GT200800201A (pt)
HR (2)	HRP20120135T1 (pt)
HU (2)	HUE032660T2 (pt)
IL (1)	IL193567A (pt)
LT (1)	LT2363392T (pt)
LU (1)	LU92232I2 (pt)
MX (1)	MX2008012527A (pt)
NO (2)	NO342090B1 (pt)
NZ (1)	NZ570887A (pt)
PL (2)	PL2363392T3 (pt)
PT (2)	PT1999109E (pt)
RS (2)	RS52222B (pt)
SG (1)	SG173338A1 (pt)
SI (2)	SI1999109T1 (pt)
TW (1)	TWI399366B (pt)
UA (1)	UA97802C2 (pt)
WO (1)	WO2007126733A2 (pt)
ZA (1)	ZA200807955B (pt)

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ES2628882T3 (es) *	2006-03-30	2017-08-04	The Trustees Of The University Of Pennsylvania	Derivados de estirilpiridina, y su uso para unir y formar imágenes de placas amiloides
EP2172444A4 (en) *	2007-07-04	2010-12-22	Univ Tohoku	PET PROBE WITH FLUORO-SUBSTITUTED ALKOXY GROUP AND HYDROXYGRUPPE
JP5603855B2 (ja)	2008-04-04	2014-10-08	アビッドレディオファーマシューティカルズ、インク．	神経変成疾患の放射性薬剤による画像化
KR20110119670A (ko) *	2008-12-31	2011-11-02	애비드 라디오파마슈티컬스, 인크.	토실레이트 전구체로부터 18ｆ―방사성표지된 스티릴피리딘의 합성 및 그로부터의 안정한 약제학적 조성물
CN102471177A (zh) *	2009-07-10	2012-05-23	拜耳医药股份有限公司	低至中压液相色谱在放射性示踪剂纯化中的应用
EP2501696B1 (en)	2009-10-15	2016-12-28	Guerbet	Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
CN102762229B9 (zh) *	2009-12-23	2020-12-01	皮拉马影像股份公司	适用于用疏水pet试剂pet成像的配方
WO2011141515A1 (en)	2010-05-14	2011-11-17	Bayer Pharma Aktiengesellschaft	Diagnostic agents for amyloid beta imaging
US20140012032A1 (en) *	2010-06-04	2014-01-09	Piramal Imaging Sa	Method for production of f-18 labeled amyloid beta ligands
CA2801530C (en)	2010-06-04	2017-09-12	Piramal Imaging Sa	Method for production of f-18 labeled amyloid beta ligands
SG185785A1 (en)	2010-06-04	2013-01-30	Piramal Imaging Sa	Method for production of f-18 labeled amyloid beta ligand
TWI504414B (zh)	2010-06-04	2015-10-21	Bayer Schering Pharma Ag	生產Ｆ－１８標記之Ａβ配位體之方法
CN101891674B (zh) *	2010-06-24	2012-11-14	山东大学	4-苯乙烯基吡啶类化合物及其制备方法与应用
EP2627361B1 (en) *	2010-10-12	2017-09-20	Mayo Foundation For Medical Education And Research	Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives
US20140079635A1 (en) *	2011-03-30	2014-03-20	Case Western Reserve University	Molecular probes for detecting lipid composition
EP2699157B1 (en)	2011-04-21	2018-03-14	The Regents of The University of California	Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
EP2768790A1 (en)	2011-10-19	2014-08-27	Piramal Imaging SA	IMPROVED METHOD FOR PRODUCTION OF F-18 LABELED Aß LIGANDS
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JP6099045B2 (ja) *	2013-04-30	2017-03-22	国立大学法人京都大学	トリアゾロピリミジン誘導体化合物
JP2014218454A (ja) *	2013-05-07	2014-11-20	日本メジフィジックス株式会社	スチリルピリジン誘導体化合物
JP6041751B2 (ja) *	2013-05-07	2016-12-14	日本メジフィジックス株式会社	スチリルピリジン誘導体化合物
CN103645254B (zh) *	2013-11-28	2015-01-07	江苏省原子医学研究所	一种Aβ斑块显像剂前体AV45的含量分析方法
SI3143011T1 (sl)	2014-05-13	2021-08-31	F. Hoffmann-La Roche Ag	Devterirane heterociklične spojine in njihova uporaba kot kontrastna sredstva
CN107949383B (zh)	2015-08-18	2022-08-23	加利福尼亚大学董事会	用于成像的含氮氧化合物的淀粉样蛋白结合剂
US10300155B2 (en)	2015-12-31	2019-05-28	Washington University	Alpha-synuclein ligands
CN109400615B (zh) *	2017-08-18	2021-07-16	上海交通大学医学院附属新华医院	一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用
CN108299287A (zh) *	2018-01-02	2018-07-20	北京师范大学	与Aβ斑块具有高亲和力的N2S2类吡啶基苯乙烯化合物
CN114805190A (zh) *	2022-06-08	2022-07-29	吉林大学第一医院	一种甲基苯胺类Aβ蛋白显像剂的双柱合成方法
CN120187703A (zh)	2022-11-14	2025-06-20	伊莱利利公司	氟贝他吡前体av-105的多晶型物

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JP2002182254A (ja)	2000-12-18	2002-06-26	Fuji Photo Film Co Ltd	非線形光学材料とその製造方法
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NZ555942A (en) *	2004-12-17	2011-01-28	Univ Pennsylvania	Radiolabelled tilbene derivatives and their use for binding and imaging amyloid plaques
US20070031328A1 (en)	2005-06-24	2007-02-08	Kung Hank F	Radiolabeled-pegylation of ligands for use as imaging agents
ES2628882T3 (es)	2006-03-30	2017-08-04	The Trustees Of The University Of Pennsylvania	Derivados de estirilpiridina, y su uso para unir y formar imágenes de placas amiloides
US20080253967A1 (en)	2007-04-13	2008-10-16	Kung Hank F	Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques

2007
- 2007-03-26 ES ES11152124.1T patent/ES2628882T3/es active Active
- 2007-03-26 ES ES07753982T patent/ES2378785T3/es active Active
- 2007-03-26 RS RS20120077A patent/RS52222B/sr unknown
- 2007-03-26 WO PCT/US2007/007400 patent/WO2007126733A2/en not_active Ceased
- 2007-03-26 AU AU2007243712A patent/AU2007243712B2/en active Active
- 2007-03-26 PT PT07753982T patent/PT1999109E/pt unknown
- 2007-03-26 UA UAA200812698A patent/UA97802C2/uk unknown
- 2007-03-26 SI SI200730865T patent/SI1999109T1/sl unknown
- 2007-03-26 HU HUE11152124A patent/HUE032660T2/en unknown
- 2007-03-26 EP EP11152115A patent/EP2363391A1/en not_active Withdrawn
- 2007-03-26 DK DK11152124.1T patent/DK2363392T3/en active
- 2007-03-26 DK DK07753982.3T patent/DK1999109T3/da active
- 2007-03-26 SG SG2011048477A patent/SG173338A1/en unknown
- 2007-03-26 RS RS20170578A patent/RS56171B1/sr unknown
- 2007-03-26 EP EP11152124.1A patent/EP2363392B1/en active Active
- 2007-03-26 US US11/727,401 patent/US7687052B2/en active Active
- 2007-03-26 SI SI200731938T patent/SI2363392T1/sl unknown
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- 2007-03-26 EP EP07753982A patent/EP1999109B1/en active Active
- 2007-03-26 HR HR20120135T patent/HRP20120135T1/hr unknown
- 2007-03-26 JP JP2009502912A patent/JP5290954B2/ja active Active
- 2007-03-26 LT LTEP11152124.1T patent/LT2363392T/lt unknown
- 2007-03-26 MX MX2008012527A patent/MX2008012527A/es active IP Right Grant
- 2007-03-26 CA CA2644530A patent/CA2644530C/en active Active
- 2007-03-26 EA EA200870389A patent/EA017898B1/ru not_active IP Right Cessation
- 2007-03-26 AT AT07753982T patent/ATE539060T1/de active
- 2007-03-26 CN CN2007800116909A patent/CN101522624B/zh active Active
- 2007-03-26 PL PL07753982T patent/PL1999109T3/pl unknown
- 2007-03-26 PT PT111521241T patent/PT2363392T/pt unknown
- 2007-03-26 NZ NZ570887A patent/NZ570887A/en unknown
- 2007-03-26 BR BRPI0710225-9A patent/BRPI0710225B1/pt active IP Right Grant
- 2007-04-26 TW TW096114833A patent/TWI399366B/zh active
2008
- 2008-08-05 US US12/186,072 patent/US8506929B2/en active Active
- 2008-08-20 IL IL193567A patent/IL193567A/en active IP Right Grant
- 2008-09-16 ZA ZA2008/07955A patent/ZA200807955B/en unknown
- 2008-09-29 KR KR1020087023884A patent/KR101376807B1/ko active Active
- 2008-09-30 CR CR10329A patent/CR10329A/es unknown
- 2008-09-30 EC EC2008008783A patent/ECSP088783A/es unknown
- 2008-09-30 GT GT200800201A patent/GT200800201A/es unknown
- 2008-10-29 NO NO20084590A patent/NO342090B1/no active Protection Beyond IP Right Term
2012
- 2012-03-07 CY CY20121100225T patent/CY1113048T1/el unknown
2013
- 2013-01-07 US US13/735,609 patent/US8840866B2/en active Active
- 2013-06-26 BE BE2013C044C patent/BE2013C044I2/fr unknown
- 2013-06-26 FR FR13C0034C patent/FR13C0034I2/fr active Active
- 2013-06-26 LU LU92232C patent/LU92232I2/fr unknown
- 2013-06-27 HU HUS1300028C patent/HUS1300028I1/hu unknown
- 2013-06-27 CY CY2013024C patent/CY2013024I1/el unknown
2017
- 2017-06-06 HR HRP20170857TT patent/HRP20170857T1/hr unknown
- 2017-06-22 CY CY20171100664T patent/CY1119048T1/el unknown
2018
- 2018-09-11 NO NO2018030C patent/NO2018030I1/no unknown

Also Published As

Publication number	Publication date
PL1999109T3 (pl)	2012-05-31
FR13C0034I1 (pt)	2013-08-09
US20130129624A1 (en)	2013-05-23
CY1119048T1 (el)	2018-01-10
CA2644530C (en)	2015-05-19
GT200800201A (es)	2009-08-20
EP2363392A1 (en)	2011-09-07
ECSP088783A (es)	2008-10-31
DK2363392T3 (en)	2017-07-03
TWI399366B (zh)	2013-06-21
US8840866B2 (en)	2014-09-23
SG173338A1 (en)	2011-08-29
ES2378785T3 (es)	2012-04-17
HRP20170857T1 (hr)	2017-12-01
IL193567A0 (en)	2009-05-04
US7687052B2 (en)	2010-03-30
NO20084590L (no)	2008-12-29
AU2007243712B2 (en)	2013-01-10
US8506929B2 (en)	2013-08-13
JP2009532349A (ja)	2009-09-10
MX2008012527A (es)	2008-10-14
EP1999109A2 (en)	2008-12-10
SI1999109T1 (sl)	2012-04-30
WO2007126733A3 (en)	2008-03-06
US20080038195A1 (en)	2008-02-14
JP5290954B2 (ja)	2013-09-18
BRPI0710225B1 (pt)	2021-07-13
AU2007243712A1 (en)	2007-11-08
KR20080106564A (ko)	2008-12-08
RS52222B (sr)	2012-10-31
PT1999109E (pt)	2012-03-16
BE2013C044I2 (pt)	2026-04-24
NO2018030I1 (no)	2018-09-11
EA017898B1 (ru)	2013-04-30
CN101522624A (zh)	2009-09-02
NZ570887A (en)	2011-05-27
RS56171B1 (sr)	2017-11-30
BRPI0710225A2 (pt)	2011-08-02
DK1999109T3 (da)	2012-04-02
CY1113048T1 (el)	2015-11-04
NO342090B1 (no)	2018-03-19
LU92232I9 (pt)	2019-01-15
CN101522624B (zh)	2013-11-06
HUS1300028I1 (hu)	2017-08-28
EP2363392B1 (en)	2017-05-03
ATE539060T1 (de)	2012-01-15
LT2363392T (lt)	2017-07-25
HUE032660T2 (en)	2017-10-30
EP2363391A1 (en)	2011-09-07
TW200838852A (en)	2008-10-01
CY2013024I2 (el)	2015-11-04
HRP20120135T1 (hr)	2012-03-31
US20090123369A1 (en)	2009-05-14
UA97802C2 (uk)	2012-03-26
CR10329A (es)	2008-10-29
LU92232I2 (fr)	2013-08-26
WO2007126733A2 (en)	2007-11-08
EA200870389A1 (ru)	2009-04-28
PL2363392T3 (pl)	2017-10-31
ZA200807955B (en)	2012-11-28
CY2013024I1 (el)	2015-11-04
FR13C0034I2 (fr)	2014-03-07
ES2628882T3 (es)	2017-08-04
EP1999109B1 (en)	2011-12-28
KR101376807B1 (ko)	2014-03-20
SI2363392T1 (sl)	2017-09-29
CA2644530A1 (en)	2007-11-08
IL193567A (en)	2014-03-31

Publication	Publication Date	Title
PT1999109E (pt)	2012-03-16	Derivados de estirilpiridina e sua utilização para ligação e obtenção de imagens de placas amilóides
MX2007007380A (es)	2007-10-11	Derivados de estilbeno y su uso para estudios de union y por imagenes de placas amiloides.
WO2007130365A3 (en)	2008-11-27	Radiolabeled dihydrotetrabenazine derivatives and their use as imaging agents
MX2008014740A (es)	2009-04-07	Derivados de 2-arilpirazolo[1,5-alfa]pirimidina-3-il acetamida como ligandos para la proteina translocadora (18 kda).
EP1874554A4 (en)	2009-01-21	METHOD AND DEVICE FOR GLOBAL EXPERIENCE FOR CT IMAGING
BRPI0816640A2 (pt)	2014-10-07	"método para produzir produtos de proteína estável ácida e produtos assim produzidos"
CR10842A (es)	2009-10-13	Derivados de acetileno y su uso para la union a placas amiloides y su diagnostico por imagenes
WO2007033080A3 (en)	2009-04-23	Alzheimer's disease imaging agents
WO2006078384A3 (en)	2007-03-01	Stilbene derivatives and their use
DK1553985T3 (da)	2011-12-12	Biphenyler som billeddannelsesmiddel i forbindelse med Alzheimers sygdom
FR2909207B1 (fr)	2009-01-30	Procede de visualisation tridimensionnelle d'images de tomosynthese en mammographie.
WO2010135493A3 (en)	2011-04-21	Alzheimer's disease imaging agents
UA91996C2 (ru)	2010-09-27	Производные стильбена и их применение для связывания и визуализации амилоидных бляшек
FR2928473B1 (fr)	2011-01-28	Procede et disositif pour assurer une coherence entre des telechargements de differentes versions d'un logiciel.
DK1748043T3 (da)	2008-12-08	Polysubstituerede 1,1-pyridinyloxycyclopropanaminderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse
EP1803734A4 (en)	2008-07-23	NEW BONE METASTASE MARKER PEPTIDE AND METHOD FOR THE DIAGNOSIS OF BONE METASTASE WHERE THIS IS USED
EP1854811A4 (en)	2008-06-04	ASSAY METHOD FOR DETECTION OF THE HUMAN OROTATE PHOSPHORIBOSYL TRANSFERASE PROTEIN
ECSP099393A (es)	2009-07-31	Derivados de acetileno y su uso para la unión a placas amiloides y su diagnóstico por imágenes
CY1115968T1 (el)	2017-01-25	Ραδιοεπισημασμενα παραγωγα διυδροτραβεναζινης και χρηση αυτων ως παραγοντες απεικονισης
BRPI0812013A2 (pt)	2017-03-21	formulações para administração oral de agentes terapêuticos e métodos relacionaods.
FI20050754A0 (fi)	2005-07-14	Menetelmä ja laite ultraäänikuvaukseen
ATE552857T1 (de)	2012-04-15	Therapeutisches mittel für neuroblastom targeting arid3b