PT2702146T - Identificação de polinucleótidos associados a uma amostra - Google Patents
Identificação de polinucleótidos associados a uma amostraInfo
- Publication number
- PT2702146T PT2702146T PT12775920T PT12775920T PT2702146T PT 2702146 T PT2702146 T PT 2702146T PT 12775920 T PT12775920 T PT 12775920T PT 12775920 T PT12775920 T PT 12775920T PT 2702146 T PT2702146 T PT 2702146T
- Authority
- PT
- Portugal
- Prior art keywords
- identification
- sample
- polynucleotides associated
- polynucleotides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Gram-negative bacteria
- C07K16/1242—Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Gram-positive bacteria
- C07K16/1271—Micrococcaceae (F); Staphylococcaceae (F), e.g. Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161517976P | 2011-04-28 | 2011-04-28 | |
| US201161575652P | 2011-08-24 | 2011-08-24 | |
| US201261599870P | 2012-02-16 | 2012-02-16 | |
| US201261608571P | 2012-03-08 | 2012-03-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2702146T true PT2702146T (pt) | 2019-04-22 |
Family
ID=47072978
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT181805979T PT3415619T (pt) | 2011-04-28 | 2012-04-27 | Identificação de polinucleótidos associados a uma amostra |
| PT12775920T PT2702146T (pt) | 2011-04-28 | 2012-04-27 | Identificação de polinucleótidos associados a uma amostra |
| PT181805995T PT3418380T (pt) | 2011-04-28 | 2012-04-27 | Identificação de polinucleótidos associados a uma amostra |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT181805979T PT3415619T (pt) | 2011-04-28 | 2012-04-27 | Identificação de polinucleótidos associados a uma amostra |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT181805995T PT3418380T (pt) | 2011-04-28 | 2012-04-27 | Identificação de polinucleótidos associados a uma amostra |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11098302B2 (pt) |
| EP (6) | EP2702146B1 (pt) |
| JP (8) | JP5998203B2 (pt) |
| KR (6) | KR102112204B1 (pt) |
| CN (3) | CN103732738A (pt) |
| AU (6) | AU2012249158B2 (pt) |
| BR (1) | BR112013027540A2 (pt) |
| CA (2) | CA3078215A1 (pt) |
| DK (3) | DK3418380T3 (pt) |
| ES (3) | ES2716013T3 (pt) |
| IL (3) | IL229122B (pt) |
| MX (1) | MX346359B (pt) |
| NZ (1) | NZ616956A (pt) |
| PL (3) | PL3415619T3 (pt) |
| PT (3) | PT3415619T (pt) |
| RU (1) | RU2644681C2 (pt) |
| SG (2) | SG194233A1 (pt) |
| SI (3) | SI3418380T1 (pt) |
| WO (1) | WO2012148497A2 (pt) |
| ZA (1) | ZA201308027B (pt) |
Families Citing this family (131)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
| CN104195227B (zh) | 2008-11-07 | 2017-04-12 | 适应生物技术公司 | 通过序列分析监测状况的方法 |
| EP2387627B1 (en) | 2009-01-15 | 2016-03-30 | Adaptive Biotechnologies Corporation | Adaptive immunity profiling and methods for generation of monoclonal antibodies |
| EP2467479B1 (en) | 2009-08-20 | 2016-01-06 | Population Genetics Technologies Ltd | Compositions and methods for intramolecular nucleic acid rearrangement |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US9834766B2 (en) | 2011-09-02 | 2017-12-05 | Atreca, Inc. | DNA barcodes for multiplexed sequencing |
| US9824179B2 (en) | 2011-12-09 | 2017-11-21 | Adaptive Biotechnologies Corp. | Diagnosis of lymphoid malignancies and minimal residual disease detection |
| US10941396B2 (en) | 2012-02-27 | 2021-03-09 | Becton, Dickinson And Company | Compositions and kits for molecular counting |
| DK2823060T3 (en) | 2012-03-05 | 2018-05-28 | Adaptive Biotechnologies Corp | Determination of associated immune receptor chains from frequency-matched subunits |
| CA2872468C (en) | 2012-05-08 | 2020-10-27 | Adaptive Biotechnologies Corporation | Compositions and methods for measuring and calibrating amplification bias in multiplexed pcr reactions |
| SG11201408128WA (en) * | 2012-06-15 | 2015-01-29 | Adaptive Biotechnologies Corp | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
| US10584381B2 (en) | 2012-08-14 | 2020-03-10 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10273541B2 (en) | 2012-08-14 | 2019-04-30 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| US10221442B2 (en) | 2012-08-14 | 2019-03-05 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| CA3216609C (en) | 2012-08-14 | 2024-05-14 | 10X Genomics, Inc. | Microcapsule compositions and methods |
| US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10150996B2 (en) | 2012-10-19 | 2018-12-11 | Adaptive Biotechnologies Corp. | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| WO2014093676A1 (en) | 2012-12-14 | 2014-06-19 | 10X Technologies, Inc. | Methods and systems for processing polynucleotides |
| AU2014214682B2 (en) | 2013-02-08 | 2018-07-26 | 10X Genomics, Inc. | Polynucleotide barcode generation |
| CN105189749B (zh) | 2013-03-15 | 2020-08-11 | 血统生物科学公司 | 用于标记和分析样品的方法和组合物 |
| US10119134B2 (en) | 2013-03-15 | 2018-11-06 | Abvitro Llc | Single cell bar-coding for antibody discovery |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| ES2711168T3 (es) | 2013-08-28 | 2019-04-30 | Becton Dickinson Co | Análisis masivo en paralelo de células individuales |
| CA2935122C (en) | 2013-12-30 | 2023-09-19 | Atreca, Inc. | Analysis of nucleic acids associated with single cells using nucleic acid barcodes |
| WO2015134787A2 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| WO2015157567A1 (en) | 2014-04-10 | 2015-10-15 | 10X Genomics, Inc. | Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same |
| US12312640B2 (en) | 2014-06-26 | 2025-05-27 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| CN113249435B (zh) | 2014-06-26 | 2024-09-03 | 10X基因组学有限公司 | 分析来自单个细胞或细胞群体的核酸的方法 |
| MX2016016904A (es) | 2014-06-26 | 2017-03-27 | 10X Genomics Inc | Analisis de secuencias de acidos nucleicos. |
| ES2895750T3 (es) * | 2014-09-15 | 2022-02-22 | Abvitro Llc | Secuenciación de alto rendimiento de colecciones de nucleótidos |
| CA2966201A1 (en) * | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| MX2017005267A (es) | 2014-10-29 | 2017-07-26 | 10X Genomics Inc | Metodos y composiciones para la secuenciacion de acidos nucleicos seleccionados como diana. |
| US10802023B2 (en) * | 2014-10-30 | 2020-10-13 | Erasmus University Medical Center Rotterdam | Reagents, methods and kits for diagnosing primary immunodeficiencies |
| US9975122B2 (en) | 2014-11-05 | 2018-05-22 | 10X Genomics, Inc. | Instrument systems for integrated sample processing |
| US10246701B2 (en) * | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| SG11201705615UA (en) | 2015-01-12 | 2017-08-30 | 10X Genomics Inc | Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same |
| BR112017018054A2 (pt) | 2015-02-24 | 2018-07-24 | 10X Genomics Inc | métodos para a cobertura de sequências de ácidos nucleicos direcionadas |
| EP4286516A3 (en) | 2015-02-24 | 2024-03-06 | 10X Genomics, Inc. | Partition processing methods and systems |
| CA2976580A1 (en) | 2015-02-24 | 2016-09-01 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
| WO2016138496A1 (en) | 2015-02-27 | 2016-09-01 | Cellular Research, Inc. | Spatially addressable molecular barcoding |
| WO2016160844A2 (en) | 2015-03-30 | 2016-10-06 | Cellular Research, Inc. | Methods and compositions for combinatorial barcoding |
| AU2016242967B2 (en) | 2015-04-01 | 2021-07-01 | Adaptive Biotechnologies Corp. | Method of identifying human compatible T cell receptors specific for an antigenic target |
| CN107580632B (zh) | 2015-04-23 | 2021-12-28 | 贝克顿迪金森公司 | 用于全转录组扩增的方法和组合物 |
| AU2016253964B2 (en) * | 2015-04-27 | 2022-07-07 | Abvitro Llc | Methods of sequencing, determining, pairing, and validating therapeutic agents and disease specific antigens |
| EP3344783A4 (en) | 2015-08-31 | 2019-07-17 | The United States Of America As Represented By The Secretary Of The Army | PROCESS FOR THE MOLECULAR CHARACTERIZATION OF CERVICAL CELL SAMPLES |
| WO2017044609A1 (en) | 2015-09-08 | 2017-03-16 | Cold Spring Harbor Laboratory | Genetic copy number determination using high throughput multiplex sequencing of smashed nucleotides |
| CN108026524A (zh) | 2015-09-11 | 2018-05-11 | 赛卢拉研究公司 | 用于核酸文库标准化的方法和组合物 |
| SG11201803646YA (en) | 2015-11-04 | 2018-05-30 | Atreca Inc | Combinatorial sets of nucleic acid barcodes for analysis of nucleic acids associated with single cells |
| SG11201804086VA (en) | 2015-12-04 | 2018-06-28 | 10X Genomics Inc | Methods and compositions for nucleic acid analysis |
| RU2756109C2 (ru) | 2016-03-10 | 2021-09-28 | Виела Байо, Инк. | Связывающие ilt7 молекулы и способы их применения |
| WO2017197343A2 (en) | 2016-05-12 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic on-chip filters |
| WO2017197338A1 (en) | 2016-05-13 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic systems and methods of use |
| US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
| US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
| US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
| EP3472355A4 (en) | 2016-06-15 | 2020-07-29 | Genecapture, Inc. | COMPOSITIONS, METHODS AND DEVICES INCLUDING ROD LOOP MOLECULES-SENSORS |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| CA3034924C (en) | 2016-09-26 | 2025-11-18 | Becton, Dickinson And Company | MEASUREMENT OF PROTEIN EXPRESSION USING REAGENTS WITH BARCODED OLIGONUCLEOTIDE SEQUENCES |
| IL266197B2 (en) * | 2016-10-24 | 2024-03-01 | Geneinfosec Inc | Hiding information contained within nucleic acids |
| JP7050057B2 (ja) | 2016-11-10 | 2022-04-07 | タカラ バイオ ユーエスエー， インコーポレイテッド | 増幅二本鎖デオキシリボ核酸の作製方法ならびに該方法で使用する組成物及びキット |
| EP4357455A3 (en) * | 2016-12-12 | 2024-07-24 | Grail, LLC | Methods for tagging and amplifying rna template molecules for preparing sequencing libraries |
| US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10011872B1 (en) | 2016-12-22 | 2018-07-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| JP7360324B2 (ja) | 2016-12-23 | 2023-10-12 | ビステラ， インコーポレイテッド | 結合ポリペプチドおよびそれを作製する方法 |
| US12264411B2 (en) | 2017-01-30 | 2025-04-01 | 10X Genomics, Inc. | Methods and systems for analysis |
| CN110214186B (zh) | 2017-01-30 | 2023-11-24 | 10X基因组学有限公司 | 用于基于微滴的单细胞条形编码的方法和系统 |
| CN110382708A (zh) | 2017-02-01 | 2019-10-25 | 赛卢拉研究公司 | 使用阻断性寡核苷酸进行选择性扩增 |
| WO2018156106A1 (en) * | 2017-02-22 | 2018-08-30 | Ding Enyu | An mrna cancer vaccine encoding human gm-csf fused to multiple tandem epitopes |
| JP6916309B2 (ja) * | 2017-03-13 | 2021-08-11 | ギガジェン，インコーポレイティッド | 単一細胞の大規模並行コンビナトリアル分析のためのシステム及び方法 |
| US10844372B2 (en) | 2017-05-26 | 2020-11-24 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
| CN109526228B (zh) | 2017-05-26 | 2022-11-25 | 10X基因组学有限公司 | 转座酶可接近性染色质的单细胞分析 |
| WO2018222741A1 (en) * | 2017-05-31 | 2018-12-06 | Oklahoma Medical Research Foundation | Bispecific antibodies for the treatment of streptococcus pneumonia |
| JP7536450B2 (ja) | 2017-06-05 | 2024-08-20 | ベクトン・ディキンソン・アンド・カンパニー | 単一細胞用のサンプルインデックス付加 |
| US20200172601A1 (en) | 2017-06-22 | 2020-06-04 | University Of Maryland, Baltimore | Broadly neutralizing antibodies against hiv |
| EP3954782A1 (en) | 2017-11-15 | 2022-02-16 | 10X Genomics, Inc. | Functionalized gel beads |
| US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| WO2019169028A1 (en) * | 2018-02-28 | 2019-09-06 | 10X Genomics, Inc. | Transcriptome sequencing through random ligation |
| CN112262218B (zh) | 2018-04-06 | 2024-11-08 | 10X基因组学有限公司 | 用于单细胞处理中的质量控制的系统和方法 |
| EP3788170B1 (en) | 2018-05-03 | 2025-01-01 | Becton, Dickinson and Company | Molecular barcoding on opposite transcript ends |
| CA3097976A1 (en) | 2018-05-03 | 2019-11-07 | Becton, Dickinson And Company | High throughput multiomics sample analysis |
| GB201810901D0 (en) * | 2018-07-03 | 2018-08-15 | Ucb Biopharma Sprl | Method |
| WO2020012446A1 (en) * | 2018-07-13 | 2020-01-16 | Enzene Biosciences Limited | Double knock-out cho cell line method of its generation and producing therapeutic proteins therefrom |
| ES2992135T3 (es) | 2018-10-01 | 2024-12-09 | Becton Dickinson Co | Determinar secuencias de transcripción 5 |
| EP3874037A4 (en) | 2018-10-31 | 2021-12-15 | Zymergen, Inc. | DETERMINIST MULTIPLEXED SET OF DNA LIBRARIES |
| JP7618548B2 (ja) | 2018-11-08 | 2025-01-21 | ベクトン・ディキンソン・アンド・カンパニー | ランダムプライミングを使用した単一細胞の全トランスクリプトーム解析 |
| US11492660B2 (en) | 2018-12-13 | 2022-11-08 | Becton, Dickinson And Company | Selective extension in single cell whole transcriptome analysis |
| KR20210141449A (ko) * | 2018-12-28 | 2021-11-23 | 내셔널 유니버시티 오브 싱가포르 | 표적화된 상보적 dna 강화를 위한 방법 |
| EP4242322B1 (en) | 2019-01-23 | 2024-08-21 | Becton, Dickinson and Company | Oligonucleotides associated with antibodies |
| CN113366104B (zh) * | 2019-01-31 | 2024-03-26 | 南特生物科学公司 | mRNA展示抗体文库和方法 |
| CN113454234B (zh) | 2019-02-14 | 2025-03-18 | 贝克顿迪金森公司 | 杂合体靶向和全转录物组扩增 |
| CN110020726B (zh) * | 2019-03-04 | 2023-08-18 | 武汉希望组生物科技有限公司 | 一种对组装序列排序的方法及系统 |
| CN120099137A (zh) | 2019-07-22 | 2025-06-06 | 贝克顿迪金森公司 | 单细胞染色质免疫沉淀测序测定 |
| JP7522189B2 (ja) | 2019-11-08 | 2024-07-24 | ベクトン・ディキンソン・アンド・カンパニー | 免疫レパートリーシーケンシングのための完全長ｖ（ｄ）ｊ情報を得るためのランダムプライミングの使用 |
| US11649497B2 (en) | 2020-01-13 | 2023-05-16 | Becton, Dickinson And Company | Methods and compositions for quantitation of proteins and RNA |
| EP4090764A1 (en) | 2020-01-13 | 2022-11-23 | Becton, Dickinson and Company | Cell capture using du-containing oligonucleotides |
| WO2021150903A1 (en) | 2020-01-22 | 2021-07-29 | Atreca, Inc. | High throughput linking of multiple transcripts |
| WO2021155057A1 (en) | 2020-01-29 | 2021-08-05 | Becton, Dickinson And Company | Barcoded wells for spatial mapping of single cells through sequencing |
| WO2021168427A1 (en) * | 2020-02-20 | 2021-08-26 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for rapid detection of sars-cov-2 |
| EP4111168A1 (en) | 2020-02-25 | 2023-01-04 | Becton Dickinson and Company | Bi-specific probes to enable the use of single-cell samples as single color compensation control |
| WO2021231237A2 (en) * | 2020-05-11 | 2021-11-18 | Augmenta Bioworks, Inc. | Antibodies for sars-cov-2 and uses thereof |
| EP4150118A1 (en) | 2020-05-14 | 2023-03-22 | Becton Dickinson and Company | Primers for immune repertoire profiling |
| US12157913B2 (en) | 2020-06-02 | 2024-12-03 | Becton, Dickinson And Company | Oligonucleotides and beads for 5 prime gene expression assay |
| WO2021257550A1 (en) * | 2020-06-15 | 2021-12-23 | Chan Zuckerberg Biohub, Inc. | Methods and compositions for selective pcr and cloning of antibody sequences |
| GB2596803A (en) * | 2020-07-06 | 2022-01-12 | Petmedix Ltd | Expression vector production & high-throughput cell screening |
| US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
| WO2022026909A1 (en) | 2020-07-31 | 2022-02-03 | Becton, Dickinson And Company | Single cell assay for transposase-accessible chromatin |
| WO2022081643A2 (en) * | 2020-10-13 | 2022-04-21 | 10X Genomics, Inc. | Compositions and methods for generating recombinant antigen binding molecules from single cells |
| WO2022082225A2 (en) * | 2020-10-16 | 2022-04-21 | The Board Of Trustees Of The Leland Stanford Junior University | Genetic tools for recombining transgenes at the same locus |
| US11739443B2 (en) | 2020-11-20 | 2023-08-29 | Becton, Dickinson And Company | Profiling of highly expressed and lowly expressed proteins |
| EP4263859A1 (en) | 2020-12-15 | 2023-10-25 | Becton, Dickinson and Company | Single cell secretome analysis |
| WO2022232258A1 (en) * | 2021-04-29 | 2022-11-03 | Pioneer Hi-Bred International, Inc. | Clubroot resistance in brassica |
| CN117769434A (zh) * | 2021-05-20 | 2024-03-26 | 黛安瑟斯医疗运营公司 | 与C1s结合的抗体和其用途 |
| AU2022292722B2 (en) | 2021-06-17 | 2025-05-22 | Atreca, Inc. | Anti-csp antibodies |
| US20250043274A1 (en) * | 2022-02-10 | 2025-02-06 | Amgen Inc. | Antibody Protein Product Expression Constructs for High Throughput Sequencing |
| EP4554973A1 (en) * | 2022-07-13 | 2025-05-21 | 10X Genomics, Inc. | Methods for characterization of antigen-binding molecules from biological samples |
| WO2024086167A2 (en) * | 2022-10-17 | 2024-04-25 | 10X Genomics, Inc. | Methods, compositions, and kits for determining the location of an analyte in a biological sample |
| AU2023385709A1 (en) | 2022-11-21 | 2025-06-12 | Dianthus Therapeutics Opco, Inc. | Antibodies that bind to c1s and uses thereof |
| WO2025072917A1 (en) * | 2023-09-28 | 2025-04-03 | The Johns Hopkins University | Barcoding intracellular reverse transcription enables high- throughput analysis of rna sequences |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001007657A1 (en) | 1999-07-27 | 2001-02-01 | Phylos, Inc. | Peptide acceptor ligation methods |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| WO1993003151A1 (en) | 1991-08-10 | 1993-02-18 | Medical Research Council | Treatment of cell populations |
| US5922545A (en) | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| US6011137A (en) * | 1996-04-03 | 2000-01-04 | University Of North Carolina At Chapel Hill | Identification and isolation of novel polypeptides having WW domains and methods of using same |
| US5928906A (en) | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
| US6261804B1 (en) | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
| DK1712623T3 (da) | 1997-01-21 | 2012-02-06 | Gen Hospital Corp | Udvælgelse af proteiner ved anvendelse af RNA-proteinfusioner |
| DE69834032T2 (de) | 1997-04-23 | 2006-12-07 | Universität Zürich | Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren |
| US6927025B1 (en) * | 1997-09-03 | 2005-08-09 | Biovation Limited | Methods for protein screening |
| WO1999016904A1 (en) | 1997-09-29 | 1999-04-08 | City Of Hope | Efficient linking of nucleic acid segments |
| AU3463699A (en) | 1998-04-03 | 1999-10-25 | Phylos, Inc. | Addressable protein arrays |
| US6846655B1 (en) | 1998-06-29 | 2005-01-25 | Phylos, Inc. | Methods for generating highly diverse libraries |
| EP1105360B1 (en) | 1998-08-17 | 2009-07-29 | Bristol-Myers Squibb Company | Identification of compound-protein interactions using libraries of protein-nucleic acid fusion molecules |
| JP2002522091A (ja) | 1998-08-17 | 2002-07-23 | フィロス インク． | ３’非翻訳領域を欠損する核酸を生成して細胞ｒｎａ蛋白質融合体形成を最適化する方法 |
| DE69935248T2 (de) | 1998-12-02 | 2007-11-08 | Adnexus Therapeutics, Inc., Waltham | Dna-protein fusionen sowie anwendungen derselben |
| DE60029572T2 (de) * | 1999-03-23 | 2007-07-26 | Biovation Ltd. | Isolierung und analyse von proteinen |
| AU779491B2 (en) | 1999-06-01 | 2005-01-27 | Bristol-Myers Squibb Company | Methods for producing 5'-nucleic acid-protein conjugates |
| US20090233806A1 (en) * | 1999-07-06 | 2009-09-17 | Carr Francis J | Protein isolation and analysis |
| EP1194594A4 (en) | 1999-07-12 | 2005-06-01 | Compound Therapeutics Inc | MARKING OF PROTEINS AT C-TERMINUS |
| AU779653B2 (en) | 1999-08-27 | 2005-02-03 | Bristol-Myers Squibb Company | Methods for encoding and sorting in vitro translated proteins |
| US6274321B1 (en) * | 1999-12-03 | 2001-08-14 | The Regents Of The University Of California | High throughput functional screening of cDNAs |
| WO2001053539A1 (en) | 2000-01-24 | 2001-07-26 | Phylos, Inc. | Sensitive, multiplexed diagnostic assays for protein analysis |
| US7022479B2 (en) | 2000-01-24 | 2006-04-04 | Compound Therapeutics, Inc. | Sensitive, multiplexed diagnostic assays for protein analysis |
| US6951725B2 (en) | 2001-06-21 | 2005-10-04 | Compound Therapeutics, Inc. | In vitro protein interaction detection systems |
| US20040161741A1 (en) * | 2001-06-30 | 2004-08-19 | Elazar Rabani | Novel compositions and processes for analyte detection, quantification and amplification |
| US7125669B2 (en) | 2001-11-27 | 2006-10-24 | Compound Therapeutics, Inc. | Solid-phase immobilization of proteins and peptides |
| JP4324649B2 (ja) * | 2001-11-28 | 2009-09-02 | 福井県 | 繊維強化熱可塑性樹脂シート及びそれを用いた構造材並びに繊維強化熱可塑性樹脂シートの製造方法 |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| DE602004026077D1 (de) * | 2003-09-10 | 2010-04-29 | Althea Technologies Inc | Erstellung von expressionsprofilen unter verwendung von mikroarrays |
| TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| CN101287831B (zh) | 2005-09-13 | 2013-05-15 | 国立大学法人三重大学 | T细胞受体和编码该受体的核酸 |
| US8642513B2 (en) * | 2005-09-15 | 2014-02-04 | Crucell Holland B.V. | Method for preparing immunoglobulin libraries |
| WO2007062064A2 (en) | 2005-11-23 | 2007-05-31 | Regents Of The University Of California, San Diego | Methods and compositions for controlling parasitic infections with bt crystal proteins |
| AU2006338198B2 (en) * | 2005-12-02 | 2012-04-26 | Genentech, Inc. | Binding polypeptides and uses thereof |
| JP2009520468A (ja) | 2005-12-23 | 2009-05-28 | ヴィヴェンティア バイオテック インコーポレーティッド | 融合タンパク質ライブラリーの作製法およびスクリーニング法、ならびにそれらの使用 |
| JP2006271390A (ja) | 2006-05-15 | 2006-10-12 | Kudo Norio | 短縮型ミッドカイン（ｔＭＫ）タンパク質特異的モノクローナル抗体の製造方法 |
| US8148085B2 (en) * | 2006-05-15 | 2012-04-03 | Sea Lane Biotechnologies, Llc | Donor specific antibody libraries |
| US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
| PT2121920E (pt) | 2007-03-01 | 2011-10-03 | Symphogen As | Método de clonagem de anticorpos cognatos |
| JP5205597B2 (ja) | 2007-06-01 | 2013-06-05 | 静岡県 | １細胞レベルでの抗体遺伝子の解析・同定方法 |
| JOP20080381B1 (ar) | 2007-08-23 | 2023-03-28 | Amgen Inc | بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9) |
| WO2009123756A1 (en) * | 2008-04-05 | 2009-10-08 | Single Cell Technology, Inc. | Multi-well system |
| US20100034807A1 (en) * | 2008-07-25 | 2010-02-11 | Matthew Moyle | Methods and compositions for discovery of target-specific antibodies using antibody repertoire array (ara) |
| RU2011117213A (ru) * | 2008-09-30 | 2012-11-10 | Эббот Лэборетриз (Us) | Улучшенные библиотеки антител |
| KR101069146B1 (ko) * | 2008-10-01 | 2011-09-30 | 주식회사에이앤알쎄라퓨틱스 | 인간 항체 ｓｃＦｖ 라이브러리 제작용 재조합 벡터, 발현벡터 및 이의 제조방법 |
| DK2356270T3 (da) * | 2008-11-07 | 2016-12-12 | Fabrus Llc | Kombinatoriske antistofbiblioteker og anvendelser deraf |
| DK3002337T3 (en) * | 2009-03-30 | 2019-02-18 | Illumina Inc | ANALYSIS OF EXPRESSION OF GENES IN SINGLE CELLS |
| KR101829182B1 (ko) | 2009-04-02 | 2018-03-29 | 플루이다임 코포레이션 | 표적 핵산의 바코딩을 위한 멀티 프라이머 증폭 방법 |
| SG175407A1 (en) * | 2009-05-29 | 2011-11-28 | Morphosys Ag | A collection and methods for its use |
| CA2772298A1 (en) | 2009-08-26 | 2011-03-03 | Research Development Foundation | Methods for creating antibody libraries |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
| CN101845500B (zh) * | 2010-05-18 | 2013-02-27 | 苏州众信生物技术有限公司 | 一种利用dna序列条码矫正二代高通量测序的序列丰度偏差的方法 |
-
2012
- 2012-04-27 PT PT181805979T patent/PT3415619T/pt unknown
- 2012-04-27 EP EP12775920.7A patent/EP2702146B1/en active Active
- 2012-04-27 KR KR1020197002835A patent/KR102112204B1/ko not_active Expired - Fee Related
- 2012-04-27 PL PL18180597T patent/PL3415619T3/pl unknown
- 2012-04-27 JP JP2014508340A patent/JP5998203B2/ja active Active
- 2012-04-27 ES ES12775920T patent/ES2716013T3/es active Active
- 2012-04-27 BR BR112013027540A patent/BR112013027540A2/pt not_active Application Discontinuation
- 2012-04-27 KR KR1020137031535A patent/KR101776192B1/ko active Active
- 2012-04-27 RU RU2013150707A patent/RU2644681C2/ru active
- 2012-04-27 WO PCT/US2012/000221 patent/WO2012148497A2/en not_active Ceased
- 2012-04-27 MX MX2013012493A patent/MX346359B/es active IP Right Grant
- 2012-04-27 PT PT12775920T patent/PT2702146T/pt unknown
- 2012-04-27 CA CA3078215A patent/CA3078215A1/en active Pending
- 2012-04-27 KR KR1020197002839A patent/KR102151656B1/ko active Active
- 2012-04-27 EP EP18180602.7A patent/EP3421591B1/en active Active
- 2012-04-27 PL PL18180599.5T patent/PL3418380T3/pl unknown
- 2012-04-27 KR KR1020177024677A patent/KR102033659B1/ko not_active Expired - Fee Related
- 2012-04-27 ES ES18180599T patent/ES2925799T3/es active Active
- 2012-04-27 CN CN201280031099.0A patent/CN103732738A/zh active Pending
- 2012-04-27 EP EP18180603.5A patent/EP3421592B1/en active Active
- 2012-04-27 DK DK18180599.5T patent/DK3418380T3/da active
- 2012-04-27 ES ES18180597T patent/ES2861595T3/es active Active
- 2012-04-27 SG SG2013080106A patent/SG194233A1/en unknown
- 2012-04-27 EP EP23189059.1A patent/EP4286855A3/en not_active Withdrawn
- 2012-04-27 US US13/261,763 patent/US11098302B2/en not_active Expired - Fee Related
- 2012-04-27 PT PT181805995T patent/PT3418380T/pt unknown
- 2012-04-27 SI SI201232007T patent/SI3418380T1/sl unknown
- 2012-04-27 SI SI201231888T patent/SI3415619T1/sl unknown
- 2012-04-27 CA CA2833917A patent/CA2833917C/en active Active
- 2012-04-27 CN CN202211461711.XA patent/CN117026386A/zh active Pending
- 2012-04-27 EP EP18180597.9A patent/EP3415619B1/en active Active
- 2012-04-27 EP EP18180599.5A patent/EP3418380B1/en active Active
- 2012-04-27 KR KR1020197002834A patent/KR102151655B1/ko active Active
- 2012-04-27 SG SG10201900183VA patent/SG10201900183VA/en unknown
- 2012-04-27 CN CN201910010319.5A patent/CN110055593A/zh active Pending
- 2012-04-27 NZ NZ616956A patent/NZ616956A/en not_active IP Right Cessation
- 2012-04-27 DK DK12775920.7T patent/DK2702146T3/en active
- 2012-04-27 SI SI201231535T patent/SI2702146T1/sl unknown
- 2012-04-27 DK DK18180597.9T patent/DK3415619T3/da active
- 2012-04-27 PL PL12775920T patent/PL2702146T3/pl unknown
- 2012-04-27 KR KR1020197002837A patent/KR102112205B1/ko not_active Expired - Fee Related
- 2012-04-27 AU AU2012249158A patent/AU2012249158B2/en not_active Ceased
-
2013
- 2013-10-28 IL IL229122A patent/IL229122B/en active IP Right Grant
- 2013-10-29 ZA ZA2013/08027A patent/ZA201308027B/en unknown
-
2016
- 2016-08-29 JP JP2016166624A patent/JP6660271B2/ja not_active Expired - Fee Related
-
2017
- 2017-09-25 AU AU2017232235A patent/AU2017232235B2/en not_active Ceased
-
2018
- 2018-06-28 US US16/022,579 patent/US20240035019A1/en not_active Abandoned
- 2018-07-26 JP JP2018139977A patent/JP6703567B2/ja not_active Expired - Fee Related
- 2018-12-31 AU AU2018286622A patent/AU2018286622B2/en not_active Ceased
- 2018-12-31 AU AU2018286623A patent/AU2018286623B2/en not_active Ceased
- 2018-12-31 AU AU2018286624A patent/AU2018286624B2/en not_active Ceased
- 2018-12-31 AU AU2018286625A patent/AU2018286625B2/en not_active Ceased
-
2019
- 2019-01-01 IL IL264056A patent/IL264056B/en unknown
- 2019-01-10 JP JP2019002451A patent/JP2019077708A/ja not_active Withdrawn
- 2019-01-10 JP JP2019002437A patent/JP2019077707A/ja not_active Withdrawn
- 2019-01-10 JP JP2019002412A patent/JP7251985B2/ja active Active
- 2019-01-10 JP JP2019002388A patent/JP2019094336A/ja not_active Withdrawn
-
2021
- 2021-11-04 JP JP2021180321A patent/JP7357661B2/ja active Active
-
2022
- 2022-02-27 IL IL290935A patent/IL290935B2/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL290935A (en) | Identification of sample-bound polynucleotides | |
| EP2880508A4 (en) | IMPROVED IDENTIFICATION OF A GESTURE | |
| ZA201307159B (en) | Automated sample preparation | |
| EP2768983A4 (en) | METHODS OF IDENTIFYING MUTATIONS ASSOCIATED WITH DISEASES | |
| EP2710582A4 (en) | DIGITAL FOOTPRINT SENSORS | |
| EP2721884A4 (en) | Location-based detection | |
| ZA201500341B (en) | Spectroscopic analysis | |
| EP2805459A4 (en) | SIMULTANEOUS PROCESS EXECUTION | |
| GB201222928D0 (en) | Analysis of a polynucleotide | |
| EP2693217A4 (en) | ANALYSIS DEVICE | |
| GB201103128D0 (en) | Location data analysis | |
| PT2920316T (pt) | Processo de fermentação | |
| GB201223495D0 (en) | A Bioreactor | |
| GB201108356D0 (en) | Event identification | |
| SG11201503020TA (en) | A novel reagent for gene-drug therapeutics | |
| PL2626134T3 (pl) | Pipeta | |
| EP2695133A4 (en) | IDENTIFICATION OF SIMILARITIES | |
| GB201100152D0 (en) | Genedrive RFID | |
| GB2502583B (en) | A device for incubating a sample | |
| EP2810427A4 (en) | CHARACTER SET FOR PRINTING PATTERNS | |
| GB2521897B (en) | Sampling Assembly for a well | |
| GB201118755D0 (en) | Identification arrangement | |
| SG11201401484YA (en) | A spectrometer | |
| EP2751750A4 (en) | IDENTIFY THE USER TARGET RELATION | |
| GB201202930D0 (en) | Identifying a mid-point |