PT2710123T - Linha celular de linfócitos compreendendo células t gama-delta, método de composição e produção resultante dos mesmos - Google Patents
Linha celular de linfócitos compreendendo células t gama-delta, método de composição e produção resultante dos mesmosInfo
- Publication number
- PT2710123T PT2710123T PT127279438T PT12727943T PT2710123T PT 2710123 T PT2710123 T PT 2710123T PT 127279438 T PT127279438 T PT 127279438T PT 12727943 T PT12727943 T PT 12727943T PT 2710123 T PT2710123 T PT 2710123T
- Authority
- PT
- Portugal
- Prior art keywords
- gama
- lymphocytes
- delta
- understanding
- cells
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title 1
- 210000004027 cell Anatomy 0.000 title 1
- 210000004698 lymphocyte Anatomy 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/32—T-cell receptors [TCR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT10571411 | 2011-05-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2710123T true PT2710123T (pt) | 2017-10-13 |
Family
ID=46317465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT127279438T PT2710123T (pt) | 2011-05-19 | 2012-05-21 | Linha celular de linfócitos compreendendo células t gama-delta, método de composição e produção resultante dos mesmos |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9499788B2 (pt) |
| EP (1) | EP2710123B1 (pt) |
| JP (1) | JP6086904B2 (pt) |
| CN (1) | CN103635573B (pt) |
| ES (1) | ES2643387T3 (pt) |
| PT (1) | PT2710123T (pt) |
| WO (1) | WO2012156958A2 (pt) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2976579B1 (fr) * | 2011-06-14 | 2013-07-05 | Coatex Sas | Epaississants non ioniques associatifs contenant des alkyls cyclohexylols, formulations les contenant et leurs utilisations |
| CN104334741B (zh) | 2012-03-28 | 2018-08-17 | 歌德塔有限公司 | 组合的γ9δ2T细胞受体链交换 |
| GB201304626D0 (en) * | 2013-03-14 | 2013-05-01 | Univ Cardiff | Method of identifying a bacterial infection |
| EP3060059A4 (en) * | 2013-10-25 | 2017-11-01 | Board of Regents, The University of Texas System | Polyclonal gamma delta t cells for immunotherapy |
| IL297773B2 (en) | 2014-11-17 | 2024-07-01 | Adicet Bio Inc | Engineered gamma delta t-cells |
| AU2016274633B2 (en) | 2015-06-09 | 2022-04-21 | Gammadelta Therapeutics Ltd | Methods for the production of TCR gamma delta+ T cells |
| DK3307875T3 (da) * | 2015-06-09 | 2022-03-21 | Lymphact Lymphocyte Activation Tech S A | Fremgangsmåder til fremstilling af tcr-gamma-delta+-t-celler |
| CN108025023A (zh) * | 2015-08-25 | 2018-05-11 | Uab研究基金会 | 用于干细胞移植的方法 |
| WO2017072367A1 (en) | 2015-10-30 | 2017-05-04 | Cancer Research Technology Limited | EXPANSION OF NON-HAEMATOPOIETIC TISSUE-RESIDENT γδ T CELLS AND USES OF THESE CELLS |
| US11299708B2 (en) | 2016-05-12 | 2022-04-12 | Adicet Bio, Inc. | Methods for selective expansion of γδ T-cell populations and compositions thereof |
| EP4099015A1 (en) | 2016-06-10 | 2022-12-07 | Gadeta B.V. | Novel method for identifying deltat-cell (or gammat-cell) receptor chains or parts thereof that mediate an anti-tumour or an anti-infective response |
| GB201707048D0 (en) | 2017-05-03 | 2017-06-14 | King S College London | Expansion of gamma delta cells, compositions, and methods of use thereof |
| EP3624823A1 (en) | 2017-05-18 | 2020-03-25 | UMC Utrecht Holding B.V. | Compositions and methods for cell targeting therapies |
| WO2018229163A1 (en) | 2017-06-14 | 2018-12-20 | King's College London | Methods of activating v delta 2 negative gamma delta t cells |
| MX2020005005A (es) | 2017-11-15 | 2020-08-27 | Adicet Bio Inc | Métodos para la expansión selectiva de poblaciones de células t gamma delta delta 3 y composiciones de estas. |
| GB201804701D0 (en) | 2018-03-23 | 2018-05-09 | Gammadelta Therapeutics Ltd | Lymphocytes expressing heterologous targeting constructs |
| CA3106056A1 (en) * | 2018-07-26 | 2020-01-30 | Ospedale Pediatrico Bambino Gesu (Opbg) | Therapeutic preparations of gamma-delta t cells and natural killer cells and methods for manufacture and use |
| US20210388100A1 (en) | 2018-10-01 | 2021-12-16 | Adicet Bio, Inc. | Compositions and methods regarding engineered and non-engineered gamma delta t-cells for treatment of hematological tumors |
| SG11202103234RA (en) | 2018-10-01 | 2021-04-29 | Adicet Bio Inc | COMPOSITIONS AND METHODS REGARDING ENGINEERED AND NON-ENGINEERED γδ -T CELLS FOR TREATMENT OF SOLID TUMORS |
| CN113423820A (zh) * | 2018-11-08 | 2021-09-21 | 伽马三角洲疗法有限公司 | 分离和扩增细胞的方法 |
| GB201818243D0 (en) | 2018-11-08 | 2018-12-26 | Gammadelta Therapeutics Ltd | Methods for isolating and expanding cells |
| JP7764364B2 (ja) | 2019-08-16 | 2025-11-05 | ガンマデルタ セラピューティクス リミティッド | エクスビボγδ Ｔ細胞集団 |
| CN110488012B (zh) * | 2019-08-30 | 2023-02-03 | 广东普锐生物科技有限公司 | 一种新生儿肺炎的辅助诊断试剂盒及应用 |
| CN115151565A (zh) | 2019-10-31 | 2022-10-04 | 莫佛塞斯公司 | 包含抗CD19抗体和γδT细胞的抗肿瘤组合疗法 |
| CN119842626A (zh) * | 2019-12-27 | 2025-04-18 | 昭泰英基生物医药（香港）有限公司 | 一种工程化免疫杀伤细胞、其制备方法及应用 |
| GB202013962D0 (en) * | 2020-09-04 | 2020-10-21 | Gammadelta Therapeutics Ltd | Immunotherapy composition |
| WO2022221506A1 (en) * | 2021-04-16 | 2022-10-20 | Acepodia Biotechnologies Ltd. | Novel compositions enriched in gamma delta t cells, methods of preparation, and uses thereof |
| CA3228168A1 (en) | 2021-08-03 | 2023-02-09 | Gammadelta Therapeutics Ltd | Engineering of gamma delta t cells and compositions thereof |
| EP4183871A1 (en) | 2021-11-23 | 2023-05-24 | Université d'Aix-Marseille | Process for preparing a composition comprising a combined cell population |
| KR20240149401A (ko) | 2022-02-16 | 2024-10-14 | 프리오테라 에스에이에스 | S1p 수용체 조정제와 조합된 car 세포를 이용한 치료 방법 |
| EP4504247A1 (en) | 2022-04-04 | 2025-02-12 | Gammadelta Therapeutics Ltd | Novel gene armoring |
| WO2025046256A1 (en) | 2023-08-31 | 2025-03-06 | Universite D'aix-Marseille | Process for preparing a composition comprising a combined cell population |
| AU2024349505A1 (en) * | 2023-09-27 | 2026-02-19 | Legend Biotech Ireland Limited | Methods of culturing gamma delta t cells |
| WO2026033421A1 (en) | 2024-08-05 | 2026-02-12 | Takeda Pharmaceutical Company Limited | IDENTIFICATION OF SUITABLE DONORS OF γδ T CELLS |
| CN121472143B (zh) * | 2026-01-06 | 2026-03-31 | 南京医拓生物科技有限公司 | 高活化状态nk细胞富集型淋巴细胞的培养方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1147186A4 (en) | 1999-01-28 | 2002-05-15 | Palmetto Health Alliance D B A | In vitro activated gamma delta lymphocytes |
| DK3246042T3 (da) | 2009-11-02 | 2019-10-14 | Univ Emory | Lægemiddelresistent immunterapi til behandling af cancer |
-
2012
- 2012-05-21 PT PT127279438T patent/PT2710123T/pt unknown
- 2012-05-21 ES ES12727943.8T patent/ES2643387T3/es active Active
- 2012-05-21 EP EP12727943.8A patent/EP2710123B1/en active Active
- 2012-05-21 US US14/118,863 patent/US9499788B2/en active Active - Reinstated
- 2012-05-21 CN CN201280024189.7A patent/CN103635573B/zh active Active
- 2012-05-21 JP JP2014510941A patent/JP6086904B2/ja active Active
- 2012-05-21 WO PCT/IB2012/052545 patent/WO2012156958A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN103635573A (zh) | 2014-03-12 |
| WO2012156958A3 (en) | 2013-01-17 |
| US20140141513A1 (en) | 2014-05-22 |
| WO2012156958A2 (en) | 2012-11-22 |
| WO2012156958A8 (en) | 2013-08-01 |
| ES2643387T3 (es) | 2017-11-22 |
| WO2012156958A4 (en) | 2013-04-04 |
| CN103635573B (zh) | 2016-05-11 |
| JP2014515259A (ja) | 2014-06-30 |
| JP6086904B2 (ja) | 2017-03-01 |
| US9499788B2 (en) | 2016-11-22 |
| EP2710123A2 (en) | 2014-03-26 |
| EP2710123B1 (en) | 2017-07-12 |
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