PT2951172T - Derivados de piridina como inibidores de rock leves - Google Patents
Derivados de piridina como inibidores de rock levesInfo
- Publication number
- PT2951172T PT2951172T PT147045322T PT14704532T PT2951172T PT 2951172 T PT2951172 T PT 2951172T PT 147045322 T PT147045322 T PT 147045322T PT 14704532 T PT14704532 T PT 14704532T PT 2951172 T PT2951172 T PT 2951172T
- Authority
- PT
- Portugal
- Prior art keywords
- pyridine derivatives
- soft rock
- rock inhibitors
- inhibitors
- soft
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000003222 pyridines Chemical class 0.000 title 1
- 239000011435 rock Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/01—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having one nitrogen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13153094 | 2013-01-29 | ||
| GB201303494A GB201303494D0 (en) | 2013-02-27 | 2013-02-27 | Novel soft rock inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2951172T true PT2951172T (pt) | 2017-07-12 |
Family
ID=50112877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT147045322T PT2951172T (pt) | 2013-01-29 | 2014-01-27 | Derivados de piridina como inibidores de rock leves |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9682963B2 (pt) |
| EP (1) | EP2951172B8 (pt) |
| KR (1) | KR102275616B1 (pt) |
| CN (1) | CN105026387B (pt) |
| AU (1) | AU2014211580B2 (pt) |
| BR (1) | BR112015018168B1 (pt) |
| CA (1) | CA2898674C (pt) |
| CY (1) | CY1119227T1 (pt) |
| DK (1) | DK2951172T3 (pt) |
| EA (1) | EA029653B1 (pt) |
| ES (1) | ES2629762T3 (pt) |
| HR (1) | HRP20170940T1 (pt) |
| HU (1) | HUE033962T2 (pt) |
| IL (1) | IL240363B (pt) |
| LT (1) | LT2951172T (pt) |
| MX (1) | MX367818B (pt) |
| NZ (1) | NZ711424A (pt) |
| PL (1) | PL2951172T3 (pt) |
| PT (1) | PT2951172T (pt) |
| RS (1) | RS56089B1 (pt) |
| SG (1) | SG11201505867PA (pt) |
| SI (1) | SI2951172T1 (pt) |
| SM (1) | SMT201700317T1 (pt) |
| WO (1) | WO2014118133A1 (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| AR110401A1 (es) | 2016-12-21 | 2019-03-27 | Chiesi Farm Spa | Derivados dihidropirimidina bicíclica-carboxamida como inhibidores de rho-quinasa |
| ES2866152T3 (es) | 2017-01-30 | 2021-10-19 | Chiesi Farm Spa | Derivados de tirosina amida como inhibidores de la Rho-quinasa |
| US11542256B2 (en) | 2017-09-03 | 2023-01-03 | Angion Biomedica Corp. | Vinylheterocycles as Rho-associated coiled-coil kinase (ROCK) inhibitors |
| MA50074A (fr) | 2017-09-07 | 2021-04-28 | Chiesi Farm Spa | Dérivés d'analogues de tyrosine en tant qu'inhibiteurs de rho-kinase |
| MA51283A (fr) | 2017-12-18 | 2021-05-26 | Chiesi Farm Spa | Dérivés de tyrosine en tant qu'inhibiteurs de kinase rho |
| MA51284A (fr) | 2017-12-18 | 2021-05-26 | Chiesi Farm Spa | Dérivés d'oxadiazole en tant qu'inhibiteurs de kinase rho |
| AR113947A1 (es) | 2017-12-18 | 2020-07-01 | Chiesi Farm Spa | Derivados de azaindol como inhibidores de rho-quinasa |
| PL3759109T3 (pl) | 2018-02-26 | 2024-03-04 | Gilead Sciences, Inc. | Podstawione związki pirolizyny jako inhibitory replikacji hbv |
| AR114926A1 (es) | 2018-06-13 | 2020-10-28 | Chiesi Farm Spa | Derivados de azaindol como inhibidores de rho-quinasa |
| TW202019923A (zh) | 2018-07-16 | 2020-06-01 | 義大利商吉斯藥品公司 | 作為Ｒｈｏ－激酶抑制劑之酪胺酸醯胺衍生物 |
| CN110917352A (zh) * | 2019-10-22 | 2020-03-27 | 天津医科大学肿瘤医院 | Rock抑制剂在肿瘤免疫治疗中的新用法 |
| CA3164134A1 (en) | 2019-12-06 | 2021-06-10 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofurans as modulators of sodium channels |
| JP2023552901A (ja) | 2020-12-15 | 2023-12-19 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | Ｒｈｏキナーゼ阻害剤としてのジヒドロフロピリジン誘導体 |
| WO2022128853A1 (en) | 2020-12-15 | 2022-06-23 | Chiesi Farmaceutici S.P.A. | Dihydrofuropyridine derivatives as rho- kinase inhibitors |
| ES3041795T3 (en) | 2020-12-15 | 2025-11-14 | Chiesi Farm Spa | Dihydrofuropyridine derivatives as rho- kinase inhibitors |
| SI4347031T1 (sl) | 2021-06-04 | 2026-01-30 | Vertex Pharmaceuticals Incorporated | N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov |
| WO2023110700A1 (en) | 2021-12-13 | 2023-06-22 | Chiesi Farmaceutici S.P.A. | Dihydrofuropyridine derivatives as rho-kinase inhibitors |
| AU2023336823A1 (en) | 2022-09-08 | 2025-02-20 | Redx Pharma Limited | Solid forms of a rock inhibitor |
| GB202403179D0 (en) | 2024-03-05 | 2024-04-17 | Redx Pharma Plc | Method of making kinase inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| CN101248046A (zh) * | 2005-07-11 | 2008-08-20 | 德福根有限公司 | 作为激酶抑制剂的酰胺衍生物 |
| BRPI0617548A2 (pt) * | 2005-10-13 | 2017-10-03 | Devgen Nv | Inibidores da quinase |
| EP2542528B1 (en) | 2010-03-02 | 2013-06-19 | Amakem NV | Heterocyclic amides as rock inhibitors |
| GB201114854D0 (en) | 2011-08-29 | 2011-10-12 | Amakem Nv | Novel rock inhibitors |
| BR112014004545A2 (pt) * | 2011-08-31 | 2017-04-04 | Amakem Nv | inibidores leves de rock |
-
2014
- 2014-01-27 PT PT147045322T patent/PT2951172T/pt unknown
- 2014-01-27 DK DK14704532.2T patent/DK2951172T3/en active
- 2014-01-27 HU HUE14704532A patent/HUE033962T2/en unknown
- 2014-01-27 LT LTEP14704532.2T patent/LT2951172T/lt unknown
- 2014-01-27 BR BR112015018168-6A patent/BR112015018168B1/pt active IP Right Grant
- 2014-01-27 KR KR1020157023210A patent/KR102275616B1/ko active Active
- 2014-01-27 SG SG11201505867PA patent/SG11201505867PA/en unknown
- 2014-01-27 SI SI201430261T patent/SI2951172T1/sl unknown
- 2014-01-27 SM SM20170317T patent/SMT201700317T1/it unknown
- 2014-01-27 PL PL14704532T patent/PL2951172T3/pl unknown
- 2014-01-27 WO PCT/EP2014/051546 patent/WO2014118133A1/en not_active Ceased
- 2014-01-27 EA EA201591371A patent/EA029653B1/ru unknown
- 2014-01-27 MX MX2015009674A patent/MX367818B/es active IP Right Grant
- 2014-01-27 RS RS20170620A patent/RS56089B1/sr unknown
- 2014-01-27 ES ES14704532.2T patent/ES2629762T3/es active Active
- 2014-01-27 HR HRP20170940TT patent/HRP20170940T1/hr unknown
- 2014-01-27 US US14/763,594 patent/US9682963B2/en active Active
- 2014-01-27 EP EP14704532.2A patent/EP2951172B8/en active Active
- 2014-01-27 AU AU2014211580A patent/AU2014211580B2/en active Active
- 2014-01-27 CN CN201480010186.7A patent/CN105026387B/zh active Active
- 2014-01-27 CA CA2898674A patent/CA2898674C/en active Active
- 2014-01-27 NZ NZ711424A patent/NZ711424A/en unknown
-
2015
- 2015-08-04 IL IL240363A patent/IL240363B/en active IP Right Grant
-
2017
- 2017-05-15 US US15/595,219 patent/US9850234B2/en active Active
- 2017-06-28 CY CY20171100684T patent/CY1119227T1/el unknown
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