MA51284A - Dérivés d'oxadiazole en tant qu'inhibiteurs de kinase rho - Google Patents

Dérivés d'oxadiazole en tant qu'inhibiteurs de kinase rho

Info

Publication number
MA51284A
MA51284A MA051284A MA51284A MA51284A MA 51284 A MA51284 A MA 51284A MA 051284 A MA051284 A MA 051284A MA 51284 A MA51284 A MA 51284A MA 51284 A MA51284 A MA 51284A
Authority
MA
Morocco
Prior art keywords
oxadiazole derivatives
rho inhibitors
kinase
kinase rho
inhibitors
Prior art date
Application number
MA051284A
Other languages
English (en)
Inventor
Alessandro Accetta
Christine Edwards
Fabio Rancati
Elizabeth Anne Skidmore
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of MA51284A publication Critical patent/MA51284A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA051284A 2017-12-18 2018-12-12 Dérivés d'oxadiazole en tant qu'inhibiteurs de kinase rho MA51284A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17208187 2017-12-18

Publications (1)

Publication Number Publication Date
MA51284A true MA51284A (fr) 2021-05-26

Family

ID=60673853

Family Applications (1)

Application Number Title Priority Date Filing Date
MA051284A MA51284A (fr) 2017-12-18 2018-12-12 Dérivés d'oxadiazole en tant qu'inhibiteurs de kinase rho

Country Status (4)

Country Link
US (1) US11578068B2 (fr)
EP (1) EP3728247B1 (fr)
MA (1) MA51284A (fr)
WO (1) WO2019121233A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230121812A (ko) 2020-12-15 2023-08-21 키에시 파르마슈티시 엣스. 피. 에이. Rho-키나아제 억제제로서 다이하이드로퓨로피리딘 유도체
KR20230121811A (ko) 2020-12-15 2023-08-21 키에시 파르마슈티시 엣스. 피. 에이. Rho-키나아제 억제제로서 다이하이드로퓨로피리딘 유도체
MX2023005867A (es) 2020-12-15 2023-06-05 Chiesi Farm Spa Derivados de dihidrofuropiridina como inhibidores de la cinasa rho.
WO2023110700A1 (fr) 2021-12-13 2023-06-22 Chiesi Farmaceutici S.P.A. Dérivés de dihydrofuropyridine utilisés comme inhibiteurs de la rho-kinase

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003278088A1 (en) 2002-10-28 2004-05-25 Bayer Healthcare Ag Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors
DE102004017438A1 (de) 2004-04-08 2005-11-03 Bayer Healthcare Ag Hetaryloxy-substituierte Phenylaminopyrimidine
WO2006009889A1 (fr) 2004-06-17 2006-01-26 Smithkline Beecham Corporation Inhibiteurs novateurs de protéines rho-kinases
US20110207704A1 (en) * 2006-12-15 2011-08-25 Abbott Laboratories Novel Oxadiazole Compounds
CA2709918A1 (fr) 2007-12-21 2009-06-25 The Scripps Research Institute Benzopyranes et analogues utilises comme inhibiteurs de la rho kinase
CN102159547A (zh) 2008-09-18 2011-08-17 安斯泰来制药株式会社 杂环甲酰胺化合物
MA34373B1 (fr) 2010-07-14 2013-07-03 Novartis Ag Composés hétérocycliques agonistes du récepteur ip
SI2951172T1 (sl) 2013-01-29 2017-08-31 Redx Pharma Plc Piridin derivati kot inhibitorji mehkih kamnov
TWI800498B (zh) 2016-12-21 2023-05-01 義大利商吉斯藥品公司 作為Rho-激酶抑制劑之雙環二氫嘧啶-羧醯胺衍生物
CA3047212A1 (fr) 2017-01-30 2018-08-02 Chiesi Farmaceutici S.P.A. Derives de tyrosine amide utilises en tant qu'inhibiteurs de la rho-kinase

Also Published As

Publication number Publication date
US20200331912A1 (en) 2020-10-22
US11578068B2 (en) 2023-02-14
EP3728247A1 (fr) 2020-10-28
WO2019121233A1 (fr) 2019-06-27
EP3728247B1 (fr) 2021-09-22

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