PT3044231T - Vetores de avv compreendendo um gene que codifica o fator viii - Google Patents

Vetores de avv compreendendo um gene que codifica o fator viii

Info

Publication number: PT3044231T
Authority: PT; Portugal
Prior art keywords: adeno; factor viii; associated virus; virus factor; vectors
Prior art date: 2013-09-12

Application number

PT147717292T

Other languages

English (en)

Original Assignee

Biomarin Pharm Inc

Univ London

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-09-12

Filing date

2014-09-10

Publication date

2020-08-27

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51585244&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3044231(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-09-10 Application filed by Biomarin Pharm Inc, Univ London filed Critical Biomarin Pharm Inc

2020-08-27 Publication of PT3044231T publication Critical patent/PT3044231T/pt

Links

241000702421 Dependoparvovirus Species 0.000 title 1
229960000301 factor viii Drugs 0.000 title 1
239000013598 vector Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14142—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Hematology (AREA)
General Engineering & Computer Science (AREA)
Epidemiology (AREA)
Biophysics (AREA)
Microbiology (AREA)
Virology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Toxicology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PT147717292T 2013-09-12 2014-09-10 Vetores de avv compreendendo um gene que codifica o fator viii PT3044231T (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201361877042P	2013-09-12	2013-09-12

Publications (1)

Publication Number	Publication Date
PT3044231T true PT3044231T (pt)	2020-08-27

Family

ID=51585244

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT147717292T PT3044231T (pt)	2013-09-12	2014-09-10	Vetores de avv compreendendo um gene que codifica o fator viii

Country Status (34)

Country	Link
US (6)	US9504762B2 (pt)
EP (2)	EP3770169A1 (pt)
JP (5)	JP6735672B2 (pt)
KR (2)	KR20230006058A (pt)
CN (2)	CN105636981B (pt)
AR (1)	AR097657A1 (pt)
AU (1)	AU2014318890B2 (pt)
CA (3)	CA3178379C (pt)
CL (1)	CL2016000502A1 (pt)
CY (2)	CY1124213T1 (pt)
DK (1)	DK3044231T3 (pt)
ES (1)	ES2813698T3 (pt)
FI (1)	FIC20230007I1 (pt)
FR (1)	FR23C1007I2 (pt)
HR (1)	HRP20201324T1 (pt)
HU (2)	HUE050484T2 (pt)
IL (2)	IL244404B (pt)
LT (2)	LT3044231T (pt)
LU (1)	LUC00298I2 (pt)
MX (2)	MX386802B (pt)
NL (1)	NL301222I2 (pt)
NO (1)	NO2023003I1 (pt)
NZ (1)	NZ716549A (pt)
PE (1)	PE20160769A1 (pt)
PH (1)	PH12016500328A1 (pt)
PL (1)	PL3044231T3 (pt)
PT (1)	PT3044231T (pt)
RS (1)	RS61039B1 (pt)
RU (1)	RU2710307C2 (pt)
SG (1)	SG11201601932UA (pt)
SI (1)	SI3044231T1 (pt)
SM (1)	SMT202000458T1 (pt)
TW (1)	TWI632239B (pt)
WO (1)	WO2015038625A1 (pt)

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US20170095538A1 (en)	2017-04-06
HK1226416A1 (en)	2017-09-29
RU2710307C2 (ru)	2019-12-26
CN105636981A (zh)	2016-06-01
JP2019193675A (ja)	2019-11-07
LT3044231T (lt)	2020-11-10
FIC20230007I1 (fi)	2023-02-08
RS61039B1 (sr)	2020-12-31
RU2019141647A (ru)	2020-01-27
SG11201601932UA (en)	2016-04-28
FR23C1007I2 (fr)	2024-06-14
US20220339262A1 (en)	2022-10-27
US10463718B2 (en)	2019-11-05
DK3044231T3 (da)	2020-09-07
KR102484396B1 (ko)	2023-01-04
ES2813698T8 (es)	2022-01-26
EP3044231A1 (en)	2016-07-20
US20250332224A1 (en)	2025-10-30
PE20160769A1 (es)	2016-08-12
PH12016500328A1 (en)	2016-05-02
TWI632239B (zh)	2018-08-11
CA2921232A1 (en)	2015-03-19
RU2016113702A (ru)	2017-10-17
IL244404B (en)	2021-10-31
NO2023003I1 (no)	2023-01-12
CN112538501A (zh)	2021-03-23
AU2014318890A1 (en)	2016-02-25
US11406690B2 (en)	2022-08-09
BR112016005576A8 (pt)	2022-10-18
JP2023133597A (ja)	2023-09-22
MX2016003262A (es)	2016-09-29
US9504762B2 (en)	2016-11-29
JP2021072871A (ja)	2021-05-13
LUC00298I2 (pt)	2025-09-22
CA3178379A1 (en)	2015-03-19
CA3178379C (en)	2026-04-21
BR112016005576A2 (pt)	2017-09-12
JP2016534739A (ja)	2016-11-10
IL286859A (en)	2021-10-31
JP2025113388A (ja)	2025-08-01
FR23C1007I1 (fr)	2023-03-24
KR20160049015A (ko)	2016-05-04
US20200101140A1 (en)	2020-04-02
EP3044231B1 (en)	2020-08-05
JP7523211B2 (ja)	2024-07-26
CN105636981B (zh)	2020-11-06
CA2921232C (en)	2023-03-14
NL301222I2 (nl)	2023-10-19
EP3770169A1 (en)	2021-01-27
CA3178384A1 (en)	2015-03-19
LTPA2023508I1 (pt)	2023-04-11
NZ716549A (en)	2022-10-28
US12239692B2 (en)	2025-03-04
CL2016000502A1 (es)	2016-10-21
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NL301222I1 (pt)	2023-03-01
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MX386802B (es)	2025-03-19
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HUE050484T2 (hu)	2020-12-28
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PL3044231T3 (pl)	2021-01-11
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IL244404A0 (en)	2016-04-21
CY2023006I2 (el)	2023-11-15
AR097657A1 (es)	2016-04-06
TW201546285A (zh)	2015-12-16
CY1124213T1 (el)	2022-03-24
JP6735672B2 (ja)	2020-08-05
ES2813698T3 (es)	2021-03-24
HRP20201324T1 (hr)	2020-11-27
WO2015038625A1 (en)	2015-03-19
US20150071883A1 (en)	2015-03-12
SI3044231T1 (sl)	2020-12-31
KR20230006058A (ko)	2023-01-10

Publication	Publication Date	Title
IL286859A (en)	2021-10-31	Adeno-associated virus factor viii vectors
ZA201507946B (en)	2020-07-29	Chimeric adeno-associated virus/ bocavirus parvovirus vector
GB201318347D0 (en)	2013-11-27	Retroviral vectors
SG11201505924TA (en)	2015-09-29	Factor viii polypeptide formulations
ZA201600729B (en)	2019-12-18	Peptides
GB201318804D0 (en)	2013-12-11	Vectors for transgene expression
ZA201504986B (en)	2019-04-24	Peptide
PT3061771T (pt)	2020-05-06	Novo péptido unido a quatro epitopos ctl
ZA201504987B (en)	2017-11-29	Peptide
GB201315130D0 (en)	2013-10-09	Peptides
GB201313535D0 (en)	2013-09-11	Hairdryers
GB201308772D0 (en)	2013-06-26	Vectors
GB201515545D0 (en)	2015-10-14	Viral peptides
GB201316660D0 (en)	2013-11-06	Peptides
GB201300381D0 (en)	2013-02-20	Peptides
GB201305465D0 (en)	2013-05-08	Novel peptides
GB201317839D0 (en)	2013-11-20	Anti-Microbial peptides
GB201318295D0 (en)	2013-11-27	Modified comb
GB201304119D0 (en)	2013-04-24	Hairdryers
GB201306435D0 (en)	2013-05-22	Vector
GB201314063D0 (en)	2013-09-18	Virus
GB201306812D0 (en)	2013-05-29	Virus