PT3105214T - Novo método de produção de cloridrato de nebivolol de elevada pureza - Google Patents
Novo método de produção de cloridrato de nebivolol de elevada purezaInfo
- Publication number
- PT3105214T PT3105214T PT15705588T PT15705588T PT3105214T PT 3105214 T PT3105214 T PT 3105214T PT 15705588 T PT15705588 T PT 15705588T PT 15705588 T PT15705588 T PT 15705588T PT 3105214 T PT3105214 T PT 3105214T
- Authority
- PT
- Portugal
- Prior art keywords
- high purity
- new method
- nebivolol hydrochloride
- producing
- producing nebivolol
- Prior art date
Links
- JWEXHQAEWHKGCW-BIISKSHESA-N (R,S,S,S)-nebivolol hydrochloride Chemical compound Cl.C1CC2=CC(F)=CC=C2O[C@H]1[C@@H](O)CNC[C@H](O)[C@H]1OC2=CC=C(F)C=C2CC1 JWEXHQAEWHKGCW-BIISKSHESA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940068174 nebivolol hydrochloride Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14155300.8A EP2907810A1 (en) | 2014-02-14 | 2014-02-14 | A new method for producing nebivolol hydrochloride of high purity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3105214T true PT3105214T (pt) | 2019-03-28 |
Family
ID=50101796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT15705588T PT3105214T (pt) | 2014-02-14 | 2015-02-13 | Novo método de produção de cloridrato de nebivolol de elevada pureza |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9822090B2 (pt) |
| EP (2) | EP2907810A1 (pt) |
| CA (1) | CA2937826A1 (pt) |
| ES (1) | ES2715503T3 (pt) |
| PT (1) | PT3105214T (pt) |
| WO (1) | WO2015121452A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102014107132A1 (de) | 2014-05-20 | 2015-11-26 | Corden Pharma International Gmbh | Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind |
| CN108300743B (zh) * | 2018-02-06 | 2021-05-14 | 江苏八巨药业有限公司 | 一种(r)-2-氯-1-(6-氟-苯并二氢吡喃-2-基)-1-乙醇的生物催化方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4654362A (en) | 1983-12-05 | 1987-03-31 | Janssen Pharmaceutica, N.V. | Derivatives of 2,2'-iminobisethanol |
| CA1337429C (en) | 1983-12-05 | 1995-10-24 | Guy Rosalia Eugene Van Lommen | Derivatives of 2,2'-iminobisethanol |
| CA1337432C (en) | 1988-03-23 | 1995-10-24 | Raymond M. Xhonneux | Method of lowering the blood pressure |
| HU227236B1 (en) | 2002-11-06 | 2010-12-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | New process for the production of racemic and the pure [2s[2r*[r[r*]]]]-and [2r[2s*[s[s*]]]]-enantiomers of nebivolol |
| EP1741712B1 (en) | 2004-07-30 | 2011-06-15 | Torrent Pharmaceuticals Ltd | amorphous form of nebivolol hydrochloride and its preparation |
| PL1776354T3 (pl) | 2004-08-11 | 2010-09-30 | Hetero Drugs Ltd | Nowy sposób wytwarzania związków pośrednich nebiwololu |
| US7560575B2 (en) | 2005-12-28 | 2009-07-14 | Acino Pharma Ag | Process for preparation of racemic Nebivolol |
| EP1803716B1 (en) | 2005-12-28 | 2012-07-25 | Acino Pharma AG | A process for preparation of racemic nebivolol |
| WO2007083318A1 (en) | 2006-01-18 | 2007-07-26 | Hetero Drugs Limited | Process for isolation of desired isomers of nebivolol intermediates |
| ES2346371T3 (es) | 2006-11-27 | 2010-10-14 | Zach System S.P.A. | Proceso para la preparacion de nebivolol. |
| JP5281012B2 (ja) | 2006-11-27 | 2013-09-04 | ザック システム エス．ピー．エー． | ネビボロールの調製方法 |
| CN101463024B (zh) | 2007-12-21 | 2011-06-08 | 上海现代制药股份有限公司 | 一种制备rrrs和sssr型的奈必洛尔中间体混合物的方法 |
| IT1392067B1 (it) * | 2008-10-31 | 2012-02-09 | Zach System Spa | Processo di preparazione di nebivololo |
| WO2010089764A2 (en) | 2009-01-05 | 2010-08-12 | Msn Laboratories Limited | Improved process for the preparation of nebivolol hydrochloride |
| DE102010005953A1 (de) | 2010-01-27 | 2011-07-28 | Corden PharmaChem GmbH, 68305 | Verfahren zur Herstellung von Nebivolol |
| CN102344431B (zh) | 2010-08-05 | 2014-03-26 | 成都康弘药业集团股份有限公司 | 一种制备奈必洛尔盐酸盐的方法 |
-
2014
- 2014-02-14 EP EP14155300.8A patent/EP2907810A1/en not_active Withdrawn
-
2015
- 2015-02-13 WO PCT/EP2015/053160 patent/WO2015121452A1/en not_active Ceased
- 2015-02-13 PT PT15705588T patent/PT3105214T/pt unknown
- 2015-02-13 ES ES15705588T patent/ES2715503T3/es active Active
- 2015-02-13 CA CA2937826A patent/CA2937826A1/en not_active Abandoned
- 2015-02-13 US US15/118,483 patent/US9822090B2/en not_active Expired - Fee Related
- 2015-02-13 EP EP15705588.0A patent/EP3105214B1/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| ES2715503T3 (es) | 2019-06-04 |
| CA2937826A1 (en) | 2015-08-20 |
| US20170183323A1 (en) | 2017-06-29 |
| US9822090B2 (en) | 2017-11-21 |
| WO2015121452A1 (en) | 2015-08-20 |
| EP3105214B1 (en) | 2018-12-19 |
| EP3105214A1 (en) | 2016-12-21 |
| EP2907810A1 (en) | 2015-08-19 |
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