PT3194592T - Bactérias termofílicas geneticamente modificadas produtoras de ácido (r)-láctico - Google Patents

Bactérias termofílicas geneticamente modificadas produtoras de ácido (r)-láctico

Info

Publication number
PT3194592T
PT3194592T PT157419631T PT15741963T PT3194592T PT 3194592 T PT3194592 T PT 3194592T PT 157419631 T PT157419631 T PT 157419631T PT 15741963 T PT15741963 T PT 15741963T PT 3194592 T PT3194592 T PT 3194592T
Authority
PT
Portugal
Prior art keywords
lactic acid
genetically modified
acid producing
thermophilic bacteria
producing thermophilic
Prior art date
Application number
PT157419631T
Other languages
English (en)
Original Assignee
Purac Biochem Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purac Biochem Bv filed Critical Purac Biochem Bv
Publication of PT3194592T publication Critical patent/PT3194592T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/56Lactic acid
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01028D-Lactate dehydrogenase (1.1.1.28)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y203/00Acyltransferases (2.3)
    • C12Y203/01Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01008Phosphate acetyltransferase (2.3.1.8)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y203/00Acyltransferases (2.3)
    • C12Y203/01Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01054Formate C-acetyltransferase (2.3.1.54), i.e. pyruvate formate-lyase or PFL
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y402/00Carbon-oxygen lyases (4.2)
    • C12Y402/03Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03003Methylglyoxal synthase (4.2.3.3)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01027L-Lactate dehydrogenase (1.1.1.27)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07Nucleotidyltransferases (2.7.7)
    • C12Y207/07006DNA-directed RNA polymerase (2.7.7.6)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT157419631T 2014-07-23 2015-07-13 Bactérias termofílicas geneticamente modificadas produtoras de ácido (r)-láctico PT3194592T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14178144 2014-07-23

Publications (1)

Publication Number Publication Date
PT3194592T true PT3194592T (pt) 2020-09-25

Family

ID=51211697

Family Applications (1)

Application Number Title Priority Date Filing Date
PT157419631T PT3194592T (pt) 2014-07-23 2015-07-13 Bactérias termofílicas geneticamente modificadas produtoras de ácido (r)-láctico

Country Status (12)

Country Link
US (1) US10731186B2 (pt)
EP (1) EP3194592B1 (pt)
JP (1) JP6637026B2 (pt)
KR (1) KR101980069B1 (pt)
CN (1) CN106574236B (pt)
AU (1) AU2015294136C9 (pt)
BR (1) BR112017000846B1 (pt)
CA (1) CA2955717C (pt)
ES (1) ES2821418T3 (pt)
PL (1) PL3194592T3 (pt)
PT (1) PT3194592T (pt)
WO (1) WO2016012296A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112019012155A2 (pt) 2016-12-14 2019-11-12 Wageningen Universiteit uso de pelo menos uma molécula-guia de rna e uma proteína cas, método de ligação, clivagem, marcação ou modificação de um polinucleotídeo alvo de fita dupla, célula transformada, e, complexo de nucleoproteína
CN113166752B (zh) * 2018-11-30 2024-08-02 株式会社Co2资源化研究所 产乳酸的嗜氢菌属细菌转化体
JP6675574B1 (ja) 2019-08-09 2020-04-01 株式会社Co2資源化研究所 乳酸を生成する遺伝子組換えヒドロゲノフィラス属細菌
CN111154705B (zh) * 2020-01-07 2021-06-29 中国科学院微生物研究所 热葡萄糖苷酶地芽孢杆菌工程菌及其构建方法及应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4336082B2 (ja) 2001-05-29 2009-09-30 花王株式会社 宿主微生物
GB0117551D0 (en) 2001-07-18 2001-09-12 Elsworth Biotech Ltd Lastic acid production
US9497168B2 (en) 2002-07-30 2016-11-15 Avaya Inc. Method and apparatus for supporting communications between a computing device within a network and an external computing device
JP4713469B2 (ja) 2003-06-18 2011-06-29 ディーエスエム アイピー アセッツ ビー.ブイ. 胞子形成できない微生物を用いたパントテネート(Pantothenate)の製造
US7098009B2 (en) * 2004-03-04 2006-08-29 University Of Florida Research Foundation, Inc. Production of chemicals from lignocellulose, biomass or sugars
DK2305826T3 (en) 2005-08-10 2016-06-27 Univ Florida Materials and methods for the efficient production of lactic acid
WO2007120198A2 (en) 2005-11-08 2007-10-25 University Of Florida Research Foundation, Inc. Materials and methods for improved microbial production of organic compounds
WO2007085443A2 (en) * 2006-01-24 2007-08-02 Purac Biochem Bv Genetic modification of homolactic thermophilic bacilli
EP2643452A4 (en) 2010-11-22 2014-07-02 Univ Florida MANIPULATION OF A HEAT-TOLERANT COOKING BACILLUS FOR THE PREPARATION OF D (-) - MILKY ACID
KR101438882B1 (ko) 2012-04-24 2014-09-05 씨제이제일제당 (주) 신규한 d형 젖산 생산균주
CN104487584B (zh) 2012-07-23 2018-05-18 三井化学株式会社 D-乳酸的生产方法、聚合物的生产方法和聚合物

Also Published As

Publication number Publication date
EP3194592A1 (en) 2017-07-26
US20170275656A1 (en) 2017-09-28
KR20170019467A (ko) 2017-02-21
JP6637026B2 (ja) 2020-01-29
KR101980069B1 (ko) 2019-05-20
PL3194592T3 (pl) 2021-02-08
BR112017000846B1 (pt) 2024-01-16
JP2017523778A (ja) 2017-08-24
BR112017000846A2 (pt) 2018-07-31
EP3194592B1 (en) 2020-07-08
CN106574236B (zh) 2020-12-11
CA2955717C (en) 2020-09-22
WO2016012296A1 (en) 2016-01-28
CA2955717A1 (en) 2016-01-28
AU2015294136C9 (en) 2019-05-02
ES2821418T3 (es) 2021-04-26
US10731186B2 (en) 2020-08-04
AU2015294136C1 (en) 2018-10-25
AU2015294136A1 (en) 2017-02-09
AU2015294136B2 (en) 2018-04-26
CN106574236A (zh) 2017-04-19

Similar Documents

Publication Publication Date Title
IL278150A (en) A transgenic bacterium for the treatment of diseases related to hyperammonemia
ZA201608303B (en) Methods for harvesting mammalian cell cultures
DK3172315T3 (da) Fagresistente mælkesyrebakterier
ZA201701424B (en) Plant inoculation method
IL252138A0 (en) Nutrient fatty acid composition is optimized
PL3766582T3 (pl) Hodowla komórek
GB201409541D0 (en) Probiotic Bacteria
GB201515330D0 (en) Bioreactor condenser
SG11201605882TA (en) Method for culturing lactic acid bacteria at high concentration
PT3194592T (pt) Bactérias termofílicas geneticamente modificadas produtoras de ácido (r)-láctico
SG11201701577WA (en) Lactic acid bacteria-containing composition
DK3068232T3 (da) Mælkesyrebakteriekultur
GB201519554D0 (en) Genetically modified microorganisms
PL3177741T3 (pl) Modyfikacja genetyczna bakterii termofilnych wytwarzających kwas s-mlekowy
SG11201609269TA (en) Method of culturing cells
ZA201700478B (en) Method for producing 2-amino-6-methylnicotinic acid
GB201421342D0 (en) Cell culture
GB201413535D0 (en) Culture
TWM489169U (en) Bioreactor for fermentation
GB201400840D0 (en) Plant inoculation