PT3596080T - Derivados de pirazolo [1,5-a]pirimidina substituídos com alicíclico farmacologicamente ativos - Google Patents

Derivados de pirazolo [1,5-a]pirimidina substituídos com alicíclico farmacologicamente ativos

Info

Publication number
PT3596080T
PT3596080T PT18713016T PT18713016T PT3596080T PT 3596080 T PT3596080 T PT 3596080T PT 18713016 T PT18713016 T PT 18713016T PT 18713016 T PT18713016 T PT 18713016T PT 3596080 T PT3596080 T PT 3596080T
Authority
PT
Portugal
Prior art keywords
pharmacologically active
substituted pyrazolo
active alicyclic
alicyclic
pyrazolo
Prior art date
Application number
PT18713016T
Other languages
English (en)
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of PT3596080T publication Critical patent/PT3596080T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT18713016T 2017-03-13 2018-03-12 Derivados de pirazolo [1,5-a]pirimidina substituídos com alicíclico farmacologicamente ativos PT3596080T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1700108A HU231058B1 (hu) 2017-03-13 2017-03-13 Gyógyászatilag hatékony aliciklusos-szubsztituált pirazolo[1,5-a]pirimidin származékok

Publications (1)

Publication Number Publication Date
PT3596080T true PT3596080T (pt) 2021-10-22

Family

ID=89992389

Family Applications (1)

Application Number Title Priority Date Filing Date
PT18713016T PT3596080T (pt) 2017-03-13 2018-03-12 Derivados de pirazolo [1,5-a]pirimidina substituídos com alicíclico farmacologicamente ativos

Country Status (32)

Country Link
US (1) US11026946B2 (pt)
EP (1) EP3596080B1 (pt)
JP (1) JP7153662B2 (pt)
KR (1) KR20190127779A (pt)
CN (1) CN110431142A (pt)
AR (1) AR111176A1 (pt)
AU (1) AU2018235266B2 (pt)
BR (1) BR112019018843A2 (pt)
CA (1) CA3056185A1 (pt)
CL (1) CL2019002601A1 (pt)
CO (1) CO2019010120A2 (pt)
CY (1) CY1124708T1 (pt)
DK (1) DK3596080T3 (pt)
EA (1) EA038756B1 (pt)
EC (1) ECSP19072975A (pt)
ES (1) ES2893824T3 (pt)
GE (1) GEP20217256B (pt)
HR (1) HRP20211850T1 (pt)
HU (2) HU231058B1 (pt)
IL (1) IL268923A (pt)
LT (1) LT3596080T (pt)
MX (1) MX2019011000A (pt)
MY (1) MY195262A (pt)
PE (1) PE20191646A1 (pt)
PH (1) PH12019501968A1 (pt)
PL (1) PL3596080T3 (pt)
PT (1) PT3596080T (pt)
RS (1) RS62533B1 (pt)
SG (1) SG11201907864YA (pt)
SI (1) SI3596080T1 (pt)
UA (1) UA124783C2 (pt)
WO (1) WO2018167630A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU231057B1 (hu) 2017-03-13 2020-04-28 Richter Gedeon Nyrt Gyógyászatilag hatékony aril-szubsztituált pirazolo[1,5-a]pirimidin származékok
CN110709084A (zh) 2017-03-13 2020-01-17 阿比德治疗公司 双重magl和faah抑制剂
TWI901650B (zh) 2020-03-26 2025-10-21 匈牙利商羅特格登公司 啶及吡啶并〔３，４－ｃ〕嗒衍生物
US12617797B2 (en) 2020-05-27 2026-05-05 Esteve Pharmaceuticals, S.A. Substituted pyrazolo [1,5-a]pyrimidines having multimodal activity against pain
TWI907472B (zh) 2020-08-05 2025-12-11 匈牙利商羅特格登公司 具藥理活性之經雜環取代的吡唑并〔１，５－ａ〕嘧啶衍生物
HU231691B1 (hu) 2021-09-29 2025-10-28 Richter Gedeon Nyrt GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok
CN115872095A (zh) * 2022-11-28 2023-03-31 南通三鑫车灯配件有限公司 一种汽车车灯反光罩的生产线流转装置

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0508310A (pt) 2004-03-02 2007-07-24 Hoffmann La Roche derivados de 4-(sulfanil-pirimidin-4-ilmetil)-morfolina e compostos relacionados como ligandos do receptor gaba, para o tratamento de ansiedade, depressão e epilepsia
GB0512844D0 (en) 2005-06-23 2005-08-03 Novartis Ag Organic compounds
KR100753017B1 (ko) 2006-05-25 2007-08-30 한국화학연구원 7-(3,4-디알콕시페닐)-피라졸로[1,5-ａ]피리미딘 화합물을포함하는 관절염, 아토피 피부염, 백혈병을 포함한 암 및알쯔하이머, 우울증 또는 기억력 감소 등의 뇌질환의 치료및 예방을 위한 약제학적 조성물
EP2271646A1 (en) 2008-03-31 2011-01-12 Takeda Pharmaceutical Company Limited Apoptosis signal-regulating kinase 1 inhibitors
TWI648281B (zh) 2013-10-17 2019-01-21 日商安斯泰來製藥股份有限公司 含硫二環式化合物
WO2016169995A1 (en) 2015-04-20 2016-10-27 AbbVie Deutschland GmbH & Co. KG Substituted pyrazolopyrimidines and method of use
JP2018199623A (ja) * 2015-10-22 2018-12-20 大正製薬株式会社 含窒素縮合複素環化合物
HU231057B1 (hu) 2017-03-13 2020-04-28 Richter Gedeon Nyrt Gyógyászatilag hatékony aril-szubsztituált pirazolo[1,5-a]pirimidin származékok

Also Published As

Publication number Publication date
SI3596080T1 (sl) 2022-01-31
AR111176A1 (es) 2019-06-12
PH12019501968A1 (en) 2020-06-29
HUE056562T2 (hu) 2022-02-28
UA124783C2 (uk) 2021-11-17
GEP20217256B (en) 2021-05-25
CN110431142A (zh) 2019-11-08
PE20191646A1 (es) 2019-11-07
US20200129515A1 (en) 2020-04-30
WO2018167630A1 (en) 2018-09-20
CY1124708T1 (el) 2022-07-22
AU2018235266B2 (en) 2021-09-30
CL2019002601A1 (es) 2020-01-24
US11026946B2 (en) 2021-06-08
EP3596080B1 (en) 2021-09-01
CA3056185A1 (en) 2018-09-20
IL268923A (en) 2019-10-31
HUP1700108A2 (en) 2018-09-28
ECSP19072975A (es) 2019-11-30
EA038756B1 (ru) 2021-10-14
LT3596080T (lt) 2021-11-25
MX2019011000A (es) 2019-10-17
MY195262A (en) 2023-01-11
HRP20211850T1 (hr) 2022-03-04
KR20190127779A (ko) 2019-11-13
CO2019010120A2 (es) 2019-10-09
RS62533B1 (sr) 2021-11-30
PL3596080T3 (pl) 2022-01-31
EP3596080A1 (en) 2020-01-22
ES2893824T3 (es) 2022-02-10
JP7153662B2 (ja) 2022-10-14
DK3596080T3 (da) 2021-11-15
BR112019018843A2 (pt) 2020-04-14
AU2018235266A1 (en) 2019-10-17
SG11201907864YA (en) 2019-09-27
HU231058B1 (hu) 2020-04-28
EA201992127A1 (ru) 2020-02-06
JP2020510041A (ja) 2020-04-02

Similar Documents

Publication Publication Date Title
HUS2200054I1 (hu) 2-fluor-N-metil-4-[7-(kinolin-6-ilmetil)imidazo[1,2-B][1,2,4]triazin-2-il]benzamid tablettás kiszerelése
IL260923B (en) History of pyrazolo[5,1-a]pyrazin-4-yl as jak inhibitors
IL266170A (en) A process for the preparation of pyrazolo[1,5-a]pyrimidines and their salts
IL263961A (en) [1, 2, 4] triazolo[1, 5-A] pyridinyl substituted indole compounds
ZA201802842B (en) [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compound
IL268923A (en) History of alicyclic-converted pyrazolo[5,1-a]pyrimidine pharmacological activity
ZA201506570B (en) 2-phenylimidazo[1,2-a]pyrimidines as imaging agents
IL246028B (en) Compounds 2 - amino - 6 - fluoro - n - [ - fluoro - pyridine - 3 yl] pyrazolo (1, 5 - a ) pyrimidine - 3 - carboxamide, their solid forms, preparations containing them and methods for their preparation
IL266305B (en) History of [4,2,1]triazolo[5,1-a]pyrimidine as pde2 inhibitors
SMT202400146T1 (it) Derivati di pirrolo [1,2-b]piridazina
IL254224A0 (en) 7-substituted 5-alkyl-[4,2,1]triazolo[5,1-a]pyrimidine derivatives as pde2 inhibitors
ZA201800485B (en) Pyrazolo[1,5-a]triazin-4-amine derivatives useful in therapy
IL262673A (en) A pyrazolo[5,1-a]pyrimidine compound
IL290419B (en) Imidazo[a-1,5]pyrazine derivatives as inhibitors of pi3k delta
ZA201605666B (en) Pyrazolo[1,5-a]pyrimidines as antiviral compounds
IL272988A (en) Imidazo-[1,5-A]pyrazine derivatives as PI3K-delta inhibitors
HUE056561T2 (hu) Gyógyászatilag hatékony aril-szubsztituált pirazolo[1,5-a]pirimidin származékok
EP3196199A4 (en) Substituted n-(pyrrolidine-3-yl)-7h-pyrrolo[2,3-d]pyrimidine-4-amine as janus kinase inhibitor